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The rapidity and low power consumption of superconducting electronics makes them an ideal substrate for physical reservoir computing, which commandeers the computational power inherent to the evolution of a dynamical system for the purposes…

Bacteria can form a great variety of spatially heterogeneous cell density patterns, ranging from simple concentric rings to dynamical spiral waves appearing in growing colonies. These pattern formation phenomena are important as they…

Populations and Evolution · Quantitative Biology 2025-01-17 John S. Chuang , Riccardo Rao , Stanislas Leibler

Reservoir computing is a machine learning paradigm that uses a high-dimensional dynamical system, or \emph{reservoir}, to approximate and predict time series data. The scale, speed and power usage of reservoir computers could be enhanced by…

Neural and Evolutionary Computing · Computer Science 2022-11-16 Forrest C. Sheldon , Artemy Kolchinsky , Francesco Caravelli

Many of the chemical reactions that take place within a living cell are irreversible. Due to evolutionary pressures, the number of allowable reactions within these systems are highly constrained and thus the resulting metabolic networks…

Molecular Networks · Quantitative Biology 2013-03-04 Jonathan J Crofts , Ernesto Estrada

Reservoir computing is a very promising approach for the prediction of complex nonlinear dynamical systems. Besides capturing the exact short-term trajectories of nonlinear systems, it has also proved to reproduce its characteristic…

Data Analysis, Statistics and Probability · Physics 2020-06-19 Alexander Haluszczynski , Jonas Aumeier , Joschka Herteux , Christoph Räth

Understanding the system level adaptive changes taking place in an organism in response to variations in the environment is a key issue of contemporary biology. Current modeling approaches such as the constraint-based flux balance analyses…

Molecular Networks · Quantitative Biology 2007-05-23 E. Almaas , Z. N. Oltvai , A. -L. Barabasi

Understanding the organization of reaction fluxes in cellular metabolism from the stoichiometry and the topology of the underlying biochemical network is a central issue in systems biology. In this task, it is important to devise reasonable…

Molecular Networks · Quantitative Biology 2009-11-13 C. Martelli , A. De Martino , E. Marinari , M. Marsili , I. Perez Castillo

We use moving light patterns to control the motion of {\it Escherichia coli} bacteria whose motility is photo-activated. Varying the pattern speed controls the magnitude and direction of the bacterial flux, and therefore the accumulation of…

Reservoir Computing (RC) is a powerful computational paradigm that allows high versatility with cheap learning. While other artificial intelligence approaches need exhaustive resources to specify their inner workings, RC is based on a…

Adaptation and Self-Organizing Systems · Physics 2018-11-26 Luís F Seoane

Reservoir computing (RC) is a state-of-the-art machine learning method that makes use of the power of dynamical systems (the reservoir) for real-time inference. When using biological complex systems as reservoir substrates, it serves as a…

Adaptation and Self-Organizing Systems · Physics 2026-03-03 Mario U. Gaimann , Miriam Klopotek

Reservoir computers (RCs) provide a computationally efficient alternative to deep learning while also offering a framework for incorporating brain-inspired computational principles. By using an internal neural network with random, fixed…

Neural and Evolutionary Computing · Computer Science 2025-04-18 Keshav Srinivasan , Dietmar Plenz , Michelle Girvan

Quantum reservoir computing employs fixed quantum dynamics as a feature map for machine learning. Integrating multiple quantum reservoirs, however, raises a key question: how few inter-module connections are sufficient to match the…

Quantum Physics · Physics 2025-11-17 Hon Wai Lau , Aoi Hayashi , Akitada Sakurai , William John Munro , Kae Nemoto

Reservoir Computing (RC) is an appealing approach in Machine Learning that combines the high computational capabilities of Recurrent Neural Networks with a fast and easy training method. Likewise, successful implementation of neuro-inspired…

Adaptation and Self-Organizing Systems · Physics 2021-07-13 Guillermo B. Morales , Claudio R. Mirasso , Miguel C. Soriano

Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological…

Molecular Networks · Quantitative Biology 2015-06-26 E. Almaas , B. Kovacs , T. Vicsek , Z. N. Oltvai , A. -L. Barabasi

The metabolic network plays a crucial role in regulating bacterial metabolism and growth, but it is subject to inherent molecular stochasticity. Previous studies have utilized flux balance analysis and the maximum entropy method to predict…

Molecular Networks · Quantitative Biology 2024-01-12 Shaohua Guan , Zhichao Zhang , Zihan Zhang , Hualin Shi

Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically…

Optimization and Control · Mathematics 2020-08-14 Amir Akbari , Bernhard O. Palsson

Machine learning approaches have recently been leveraged as a substitute or an aid for physical/mathematical modeling approaches to dynamical systems. To develop an efficient machine learning method dedicated to modeling and prediction of…

Machine Learning · Computer Science 2022-08-01 Gouhei Tanaka , Tadayoshi Matsumori , Hiroaki Yoshida , Kazuyuki Aihara

Bacteria live in environments that are continuously fluctuating and changing. Exploiting any predictability of such fluctuations can lead to an increased fitness. On longer timescales bacteria can "learn" the structure of these fluctuations…

Cell Behavior · Quantitative Biology 2021-01-05 Stefan Landmann , Caroline M. Holmes , Mikhail Tikhonov

Bacteria are prolific at colonizing diverse surfaces under a widerange of environmental conditions, and exhibit fascinating examples of self-organization across scales. Though it has recently attracted considerable interest, the role of…

Soft Condensed Matter · Physics 2024-03-25 M. T. Khan , J. Cammann , A. Sengupta , E. Renzi , M. G. Mazza

The investigation of spatio-temporal dynamics of bacterial cells and their molecular components requires automated image analysis tools to track cell shape properties and molecular component locations inside the cells. In the study of…

Computer Vision and Pattern Recognition · Computer Science 2016-12-23 Jean-Pascal Jacob , Mariella Dimiccoli , Lionel Moisan