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Large-scale neural recording with high spatio-temporal resolution is essential for understanding information processing in brain, yet current neural interfaces fall far short of comprehensively capturing brain activity due to extremely high…

A technology for recording electrical activity of large neuron populations at arbitrary depth in brain tissues with less than cell spatial and millisecond temporal resolutions was the most craving dream of neuroscientists and a long pursued…

Biological Physics · Physics 2013-09-02 Roman V. Beletskiy

We describe the application of nanoelectromechanical systems (NEMS) to ultrasensitive mass detection. In these experiments, a modulated flux of atoms was adsorbed upon the surface of a 32.8 MHz NEMS resonator within an ultrahigh vacuum…

Other Condensed Matter · Physics 2009-11-10 K. L. Ekinci , X. M. H. Huang , M. L. Roukes

Extracellular, large scale in vivo recording of neural activity is mandatory for elucidating the interaction of neurons within large neural networks at the level of their single unit activity. Technological achievements in MEMS-based…

Neurons and Cognition · Quantitative Biology 2017-07-03 Patrick Ruther , Oliver Paul

Microelectromechanical systems (MEMS) have been applied to many measurement problems in physics, chemistry, biology and medicine. In parallel, cavity optomechanical systems have achieved quantum-limited displacement sensitivity and ground…

Optics · Physics 2012-07-23 Houxun Miao , Kartik Srinivasan , Vladimir Aksyuk

Nanoelectromechanical systems, or NEMS, are MEMS scaled to submicron dimensions. In this size regime, it is possible to attain extremely high fundamental frequencies while simultaneously preserving very high mechanical responsivity (small…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 M. L. Roukes

Neural probes are in vivo invasive devices that combine electrophysiology and optogenetics to gain insight into how the brain operates, down to the single neuron and its network activity. Their integration of stimulation sites and sensors…

Nanoelectromechanical systems (NEMSs) are emerging nanoscale elements at the crossroads between mechanics, optics and electronics, with significant potential for actuation and sensing applications. The reduction of dimensions compared to…

Mesoscale and Nanoscale Physics · Physics 2012-03-20 Antoine Reserbat-Plantey , Laetitia Marty , Olivier Arcizet , Nedjma Bendiab , Vincent Bouchiat

Advanced neural interfaces mediate a bio-electronic link between the nervous system and microelectronic devices, bearing great potential as innovative therapy for various diseases. Spikes from a large number of neurons are recorded leading…

Emerging Technologies · Computer Science 2016-11-30 Isha Gupta , Alexantrou Serb , Ali Khiat , Ralf Zeitler , Stefano Vassanelli , Themistoklis Prodromakis

Nanoelectromechanical Systems (NEMS) have emerged as a promising technology for performing the mass spectrometry of large biomolecules and nanoparticles. As nanoscale objects land on NEMS sensor one by one, they induce resolvable shifts in…

Mesoscale and Nanoscale Physics · Physics 2019-07-24 Mert Yuksel , Ezgi Orhan , Cenk Yanik , Atakan B. Ari , Alper Demir , M. Selim Hanay

A new class of hybrid systems that couple optical, electrical and mechanical degrees of freedom in nanoscale devices is under development in laboratories worldwide. These nano-opto-electro-mechanical systems (NOEMS) offer unprecedented…

Optics · Physics 2018-02-16 Leonardo Midolo , Albert Schliesser , Andrea Fiore

Nanoelectromechanical systems (NEMS) are nano-to-micrometer scale mechanical resonators coupled to electronic devices of similar dimensions. NEMS show promise for fast, ultrasensitive force microscopy and for deepening our understanding of…

Mesoscale and Nanoscale Physics · Physics 2015-06-25 M. P. Blencowe

The scanning electron microscope (SEM) recordings of dynamic nano-electromechanical systems (NEMS) are difficult to analyze due to the noise caused by low frame rate, insufficient resolution and blurriness induced by applied electric…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Ege Erdem , Berke Demiralp , Hadi S Pisheh , Peyman Firoozy , Ahmet Hakan Karakurt , M. Selim Hanay

Nanoelectromechanical systems (NEMS) have generated considerable interest as inertial mass sensors. NEMS resonators have been used to weigh cells, biomolecules, and gas molecules, creating many new possibilities for biological and chemical…

Mesoscale and Nanoscale Physics · Physics 2012-04-13 J. Chaste , A. Eichler , J. Moser , G. Ceballos , R. Rurali , A. Bachtold

Neuropathies are gaining higher relevance in clinical settings, as they risk permanently jeopardizing a person's life. To support the recovery of patients, the use of fully implanted devices is emerging as one of the most promising…

Artificial Intelligence · Computer Science 2024-04-03 Antonio Coviello , Francesco Linsalata , Umberto Spagnolini , Maurizio Magarini

We present Neural Memory Object (NeMO), a novel object-centric representation that can be used to detect, segment and estimate the 6DoF pose of objects unseen during training using RGB images. Our method consists of an encoder that requires…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Sebastian Jung , Leonard Klüpfel , Rudolph Triebel , Maximilian Durner

This PhD thesis introduces the concept of meta-electrodes coupled with laser optoporation for high quality intracellular signals from hiPSCs-CM. These signals can be recorded on high-density commercial CMOS-MEAs from 3Brain characterized by…

Biological Physics · Physics 2022-12-20 Giovanni Melle

Integrated chemical and biological sensors give advantages in cost, size and weight reduction and open new prospects for parallel monitoring and analysis. Biosensors based on nanoelectromechanical systems (NEMS) are the most attractive…

Optics · Physics 2019-04-29 Dmitry Yu. Fedyanin , Yury V. Stebunov

A variety of scientific fields like proteomics and spintronics have created a new demand for on-chip devices capable of sensing parameters localized within a few tens of micrometers. Nano and microelectromechanical systems (NEMS/MEMS) are…

Detecting monotonic changes in heart rate (HR) is crucial for early identification of cardiac conditions and health management. This is particularly important for dementia patients, where HR trends can signal stress or agitation. Developing…

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