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Sequential modelling of high-dimensional data is an important problem that appears in many domains including model-based reinforcement learning and dynamics identification for control. Latent variable models applied to sequential data…

Machine Learning · Computer Science 2023-01-23 Oliver Limoyo , Trevor Ablett , Jonathan Kelly

Many real-world tasks are plagued by limitations on data: in some instances very little data is available and in others, data is protected by privacy enforcing regulations (e.g. GDPR). We consider limitations posed specifically on…

Machine Learning · Computer Science 2022-05-24 Padmanaba Srinivasan , William J. Knottenbelt

In this paper, we present a new perspective towards image-based shape generation. Most existing deep learning based shape reconstruction methods employ a single-view deterministic model which is sometimes insufficient to determine a single…

Computer Vision and Pattern Recognition · Computer Science 2019-04-23 Yi Wei , Shaohui Liu , Wang Zhao , Jiwen Lu , Jie Zhou

LAGE is a systematic framework developed in Java. The motivation of LAGE is to provide a scalable and parallel solution to reconstruct Gene Regulatory Networks (GRNs) from continuous gene expression data for very large amount of genes. The…

Machine Learning · Computer Science 2012-11-12 Yang Lu , Mengying Wang , Kenny Q. Zhu , Bo Yuan

Many promising applications of supervised machine learning face hurdles in the acquisition of labeled data in sufficient quantity and quality, creating an expensive bottleneck. To overcome such limitations, techniques that do not depend on…

Machine Learning · Computer Science 2023-03-14 Benedikt Boecking , Nicholas Roberts , Willie Neiswanger , Stefano Ermon , Frederic Sala , Artur Dubrawski

Advances in single-cell sequencing have enabled high-resolution profiling of diverse molecular modalities, while integrating unpaired multi-omics single-cell data remains challenging. Existing approaches either rely on pair information or…

Quantitative Methods · Quantitative Biology 2026-01-21 Jianle Sun , Chaoqi Liang , Ran Wei , Peng Zheng , Lei Bai , Wanli Ouyang , Hongliang Yan , Peng Ye

Conditional generative adversarial networks (cGANs) have shown superior results in class-conditional generation tasks. To simultaneously control multiple conditions, cGANs require multi-label training datasets, where multiple labels can be…

Machine Learning · Computer Science 2023-05-30 Youngin Cho , Daejin Kim , Mohammad Azam Khan , Jaegul Choo

The characterization of subsurface models relies on the accuracy of subsurface models which request integrating a large number of information across different sources through model conditioning, such as data conditioning and geological…

Applications · Statistics 2024-04-09 Lei Liu , Eduardo Maldonado-Cruz , Honggeun Jo , Maša Prodanović , Michael J. Pyrcz

The generation of complex, large-scale code projects using generative AI models presents challenges due to token limitations, dependency management, and iterative refinement requirements. This paper introduces the See-Saw generative…

Machine Learning · Computer Science 2024-11-19 Ruslan Idelfonso Magaña Vsevolodovna

Group-based policy optimization methods like GRPO and GSPO have become standard for training multimodal models, leveraging group-wise rollouts and relative advantage estimation. However, they suffer from a critical \emph{gradient vanishing}…

Machine Learning · Computer Science 2025-11-25 Zengjie Hu , Jiantao Qiu , Tianyi Bai , Haojin Yang , Binhang Yuan , Qi Jing , Conghui He , Wentao Zhang

Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

Genomics · Quantitative Biology 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

Recent image generation approaches often address subject, style, and structure-driven conditioning in isolation, leading to feature entanglement and limited task transferability. In this paper, we introduce 3SGen, a task-aware unified…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Xinyang Song , Libin Wang , Weining Wang , Zhiwei Li , Jianxin Sun , Dandan Zheng , Jingdong Chen , Qi Li , Zhenan Sun

Single-cell RNA sequencing (scRNA-seq) data exhibit strong and reproducible statistical structure. This has motivated the development of large-scale foundation models, such as TranscriptFormer, that use transformer-based architectures to…

Genomics · Quantitative Biology 2026-02-19 Huan Souza , Pankaj Mehta

Modern Large Foundation Model (LFM) training has transformed the data pipeline from a static ingestion layer into a dynamic component that must co-evolve with the training process. Existing systems are ill-equipped: colocated dataloaders…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-18 Ting Sun , Junjie Zhang , Xiao Yan , Songxin Zhang , Zhuoyang Song , Jingyi Xi , Zunyao Mao , Bingyi Jing , Jiaxing Zhang , Zejian Xie

Structured output representation is a generative task explored in computer vision that often times requires the mapping of low dimensional features to high dimensional structured outputs. Losses in complex spatial information in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-25 Mohamed Debbagh

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

Machine Learning · Statistics 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak

Requirements of large amounts of data is a difficulty in training many GANs. Data efficient GANs involve fitting a generators continuous target distribution with a limited discrete set of data samples, which is a difficult task. Single…

Computer Vision and Pattern Recognition · Computer Science 2023-03-09 Rajiv Kumar , G. Sivakumar

Chemical reactions are the fundamental building blocks of drug design and organic chemistry research. In recent years, there has been a growing need for a large-scale deep-learning framework that can efficiently capture the basic rules of…

Machine Learning · Computer Science 2024-03-08 Bo Qiang , Yiran Zhou , Yuheng Ding , Ningfeng Liu , Song Song , Liangren Zhang , Bo Huang , Zhenming Liu

We introduce a simple but effective unsupervised method for generating realistic and diverse images. We train a class-conditional GAN model without using manually annotated class labels. Instead, our model is conditional on labels…

Computer Vision and Pattern Recognition · Computer Science 2022-02-11 Steven Liu , Tongzhou Wang , David Bau , Jun-Yan Zhu , Antonio Torralba

Customizing image generation remains a core challenge in controllable image synthesis. For single-concept generation, maintaining both identity preservation and prompt alignment is challenging. In multi-concept scenarios, relying solely on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Trong-Vu Hoang , Quang-Binh Nguyen , Thanh-Toan Do , Tam V. Nguyen , Minh-Triet Tran , Trung-Nghia Le