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We propose a Bayesian latent variable model to estimate covariate-assisted dependence structures across multiple modalities of multivariate data that may be observed asynchronously. This setting commonly arises in longitudinal biomedical…

Methodology · Statistics 2026-05-27 Kun Qian , Hyung G. Park

Multidisciplinary team (MDT) consultations are the gold standard for cancer care decision-making, yet current practice lacks structured mechanisms for quantifying consensus and ensuring decision traceability. We introduce a Multi-Agent…

Multiagent Systems · Computer Science 2025-12-17 Xudong Han , Xianglun Gao , Xiaoyi Qu , Zhenyu Yu

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

We present a fully automated learning-based approach for segmenting knee cartilage in the presence of osteoarthritis (OA). The algorithm employs a hierarchical set of two random forest classifiers. The first is a neighborhood approximation…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Satyananda Kashyap , Ipek Oguz , Honghai Zhang , Milan Sonka

Accurate beam prediction is essential for mitigating signalling overhead and latency in integrated sensing and communication-enabled massive multi-input multi-output systems. With the aid of multimodal learning, the prediction accuracy can…

Signal Processing · Electrical Eng. & Systems 2026-05-15 Zijian Zheng , Wenqiang Yi , Hyundong Shin , Arumugam Nallanathan

Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Yifei Chen , Shenghao Zhu , Zhaojie Fang , Chang Liu , Binfeng Zou , Yuhe Wang , Shuo Chang , Fan Jia , Feiwei Qin , Jin Fan , Yong Peng , Changmiao Wang

Healthcare foundation models have largely followed paradigms from natural language processing and computer vision, emphasizing large scale pretraining and deterministic representations over heterogeneous clinical data. However, clinical…

Machine Learning · Computer Science 2026-04-07 Qian Zhou , Yuanyun Zhang , Shi Li

Normative modeling is an emerging and promising approach to effectively study disorder heterogeneity in individual participants. In this study, we propose a novel normative modeling method by combining conditional variational autoencoder…

Machine Learning · Computer Science 2022-11-17 Xuetong Wang , Kanhao Zhao , Rong Zhou , Alex Leow , Ricardo Osorio , Yu Zhang , Lifang He

Objective assessment of Magnetic Resonance Imaging (MRI) scans of osteoarthritis (OA) can address the limitation of the current OA assessment. Segmentation of bone, cartilage, and joint fluid is necessary for the OA objective assessment.…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Banafshe Felfeliyan , Abhilash Hareendranathan , Gregor Kuntze , Jacob L. Jaremko , Janet L. Ronsky

Artificial intelligence holds strong potential to support clinical decision making in intensive care units where timely and accurate risk assessment is critical. However, many existing models focus on isolated outcomes or limited data…

Dementia is a neurodegenerative condition that combines several diseases and impacts millions around the world and those around them. Although cognitive impairment is profoundly disabling, it is the noncognitive features of dementia,…

Multimedia · Computer Science 2025-08-08 Abeer Badawi , Somayya Elmoghazy , Samira Choudhury , Sara Elgazzar , Khalid Elgazzar , Amer Burhan

Deep Learning models are easily disturbed by variations in the input images that were not seen during training, resulting in unpredictable behaviours. Such Out-of-Distribution (OOD) images represent a significant challenge in the context of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Benjamin Lambert , Florence Forbes , Senan Doyle , Alan Tucholka , Michel Dojat

Background: MRI is the modality of choice for cartilage imaging; however, its diagnostic performance is variable and significantly lower than the gold standard diagnostic knee arthroscopy. In recent years, deep learning has been used to…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Gergo Merkely , Alireza Borjali , Molly Zgoda , Evan M. Farina , Simon Gortz , Orhun Muratoglu , Christian Lattermann , Kartik M. Varadarajan

Radiographic grading of knee osteoarthritis (KOA) with the Kellgren-Lawrence (KL) system is limited by inter-reader variability and the opacity of current deep learning approaches, which predict KL grades directly from images without…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Azmul A. Irfan , Nur Ahmad Khatim , Alfan Alfian Irfan , Achmad Zaki , Erike A. Suwarsono , Mansur M. Arief

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from…

Machine Learning · Computer Science 2026-05-19 Xiaoguang Zhu , Linxiao Gong , Lianlong Sun , Yang Liu , Haoyu Wang , Jing Liu

Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…

Brain tissue segmentation from multimodal MRI is a key building block of many neuroscience analysis pipelines. It could also play an important role in many clinical imaging scenarios. Established tissue segmentation approaches have however…

Image and Video Processing · Electrical Eng. & Systems 2020-04-15 Reuben Dorent , Wenqi Li , Jinendra Ekanayake , Sebastien Ourselin , Tom Vercauteren

Automated dysarthria detection and severity assessment from speech have attracted significant research attention due to their potential clinical impact. Despite rapid progress in acoustic modeling and deep learning, models still fall short…

Audio and Speech Processing · Electrical Eng. & Systems 2025-10-28 Krishna Gurugubelli

Diagnosing Autism Spectrum Disorder (ASD) is a challenging problem, and is based purely on behavioral descriptions of symptomology (DSM-5/ICD-10), and requires informants to observe children with disorder across different settings (e.g.…

Neurons and Cognition · Quantitative Biology 2020-03-04 Taban Eslami , Joseph S. Raiker , Fahad Saeed

In recent years, deep learning models have been applied to neuroimaging data for early diagnosis of Alzheimer's disease (AD). Structural magnetic resonance imaging (sMRI) and positron emission tomography (PET) images provide structural and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Yanteng Zhanga , Xiaohai He , Yi Hao Chan , Qizhi Teng , Jagath C. Rajapakse