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Microbiome-based stratification of healthy individuals into compositional categories, referred to as "community types", holds promise for drastically improving personalized medicine. Despite this potential, the existence of community types…

Quantitative Methods · Quantitative Biology 2016-04-27 Travis E. Gibson , Amir Bashan , Hong-Tai Cao , Scott T. Weiss , Yang-Yu Liu

I give a highly selective overview of the way statistical mechanics explains the microscopic origins of the time asymmetric evolution of macroscopic systems towards equilibrium and of first order phase transitions in equilibrium. These…

Mathematical Physics · Physics 2009-10-31 Joel L. Lebowitz

Statistical fluctuations in population sizes of microbes may be quite large depending on the nature of their underlying stochastic dynamics. For example, the variance of the population size of a microbe undergoing a pure birth process with…

Populations and Evolution · Quantitative Biology 2012-06-27 Dipjyoti Das , Dibyendu Das , Ashok Prasad

It has been known for many years that small fractions of persister cells resist killing in many bacterial colony-antimicrobial confrontations. These persisters are not believed to be mutants. Rather it has been hypothesized that they are…

Cell Behavior · Quantitative Biology 2007-05-23 I. Klapper , P. Gilbert , B. P. Ayati , J. Dockery , P. S. Stewart

In this review, we discuss modularity and hierarchy in biological systems. We review examples from protein structure, genetics, and biological networks of modular partitioning of the geometry of biological space. We review theories to…

Populations and Evolution · Quantitative Biology 2015-06-04 Dirk M. Lorenz , Alice Jeng , Michael W. Deem

Although ubiquitous, interactions of groups of individuals (e.g., modern messaging applications, group meetings, or even a parliament discussion) are not yet thoroughly studied. Frequently, single-groups are modeled as critical-mass…

Physics and Society · Physics 2023-06-19 Guilherme Ferraz de Arruda , Giovanni Petri , Pablo Martín Rodriguez , Yamir Moreno

Which factors govern the evolution of mutation rates and emergence of species? Here, we address this question using a first principles model of life where population dynamics of asexual organisms is coupled to molecular properties and…

Populations and Evolution · Quantitative Biology 2009-11-13 Muyoung Heo , Louis Kang , Eugene I. Shakhnovich

Ecosystems can undergo sudden shifts to undesirable states, but recent studies with simple single species ecosystems have demonstrated that advance warning can be provided by the slowing down of population dynamics near a tipping point.…

Populations and Evolution · Quantitative Biology 2015-06-16 Andrew Chen , Alvaro Sanchez , Lei Dai , Jeff Gore

Clonal microbes can switch between different phenotypes and recent theoretical work has shown that stochastic switching between these subpopulations can stabilize microbial communities. This phenotypic switching need not be stochastic,…

Populations and Evolution · Quantitative Biology 2025-12-12 Pierre A. Haas , Maria A. Gutierrez , Nuno M. Oliveira , Raymond E. Goldstein

The goal of this article is to contribute towards the conceptual and quantitative understanding of the evolutionary benefits for (microbial) populations to maintain a seed bank (consisting of dormant individuals) when facing fluctuating…

Probability · Mathematics 2024-07-02 Jochen Blath , Felix Hermann , Martin Slowik

Although it is well-known that some exponential family random graph model (ERGM) families exhibit phase transitions (in which small parameter changes lead to qualitative changes in graph structure), the behavior of other models is still…

Social and Information Networks · Computer Science 2020-01-07 Carter T. Butts

Evolutionary transitions among ecological interactions are widely known, although their detailed dynamics remain absent for most population models. Adaptive dynamics has been used to illustrate how the parameters of population models might…

Populations and Evolution · Quantitative Biology 2022-11-14 Luciano Stucchi , Javier Galeano , Juan Manuel Pastor , José María Iriondo , José A. Cuesta

Recently, dynamical phase transitions have been identified based on the non-analytic behavior of the Loschmidt echo in the thermodynamic limit [Heyl et al., Phys.~Rev.~Lett.~{\bf 110}, 135704 (2013)]. By introducing conditional probability…

Strongly Correlated Electrons · Physics 2015-01-09 Elena Canovi , Philipp Werner , Martin Eckstein

In the present paper, we characterize the behavior of supercritical branching processes in random environment with linear fractional offspring distributions, conditioned on having small, but positive values at some large generation. As it…

Probability · Mathematics 2014-05-20 Christian Böinghoff

We present results on a stochastic forest fire model, where the influence of the neighbour trees is treated in a more realistic way than usual and the definition of neighbourhood can be tuned by an additional parameter. This model exhibits…

Cellular Automata and Lattice Gases · Physics 2015-05-13 Klaus Lichtenegger , Wilhelm Schappacher

We study the evolution of artificial learning systems by means of selection. Genetic programming is used to generate a sequence of populations of algorithms which can be used by neural networks for supervised learning of a rule that…

Biological Physics · Physics 2009-11-07 Juan Pablo Neirotti , Nestor Caticha

Laboratory experiments with bacterial colonies, under well-controlled conditions often lead to evolutionary diversification, where at least two ecotypes emerge from an initially monomorphic population. Empirical evidence suggests that such…

Populations and Evolution · Quantitative Biology 2024-11-06 Roberto Corral López , Samir Suweis , Sandro Azaele , Miguel A. Muñoz

A general system of particles (of one or several species) on a one dimensional lattice with boundaries is considered. Two general behaviors of such systems are investigated. The stationary behavior of the system, and the dominant way of the…

Statistical Mechanics · Physics 2015-06-24 Mohammad Khorrami , Amir Aghamohammadi

We study a one parameter family of random graph models that spans a continuum between traditional random graphs of the Erd\H{o}s-R\'enyi type, where there is no underlying structure, and percolation models, where the possible edges are…

Probability · Mathematics 2008-04-02 Oskar Sandberg

Phase transitions are fundamental features of statistical physics. While the well-studied continuous phase transitions are known to be controlled by external \textit{macroscopic} changes in the order parameter, the origin of abrupt…

Physics and Society · Physics 2024-10-25 Bnaya Gross , Irina Volotsenko , Yuval Sallem , Nahala Yadid , Ivan Bonamassa , Shlomo Havlin , Aviad Frydman