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We consider the problem of estimating the topology of spatial interactions in a discrete state, discrete time spatio-temporal graphical model where the interactions affect the temporal evolution of each agent in a network. Among other…

Machine Learning · Statistics 2010-04-15 Patrick L. Harrington , Alfred O. Hero

Obesity is a serious public health concern world-wide, which increases the risk of many diseases, including hypertension, stroke, and type 2 diabetes. To tackle this problem, researchers across the health ecosystem are collecting diverse…

Machine Learning · Computer Science 2018-09-24 Qinghan Xue , Xiaoran Wang , Samuel Meehan , Jilong Kuang , Alex Gao , Mooi Choo Chuah

Purpose: To develop a neural ordinary differential equation (ODE) model for visualizing deep neural network (DNN) behavior during multi-parametric MRI (mp-MRI) based glioma segmentation as a method to enhance deep learning explainability.…

Quantitative Methods · Quantitative Biology 2022-03-25 Zhenyu Yang , Zongsheng Hu , Hangjie Ji , Kyle Lafata , Scott Floyd , Fang-Fang Yin , Chunhao Wang

In this paper, we develop a node-based approximate model for Markovian contagion dynamics on networks. We prove that our approximate model is exact for SIR (susceptible-infectious-recovered) and SEIR…

Dynamical Systems · Mathematics 2021-08-17 Cameron L. Hall , Bram A. Siebert

This paper introduces a nonstandard finite difference (NSFD) approach to a reaction-diffusion SEIQR epidemiological model, which captures the spatiotemporal dynamics of infectious disease transmission. Formulated as a system of semilinear…

Quantitative Methods · Quantitative Biology 2026-05-20 Achraf Zinihi , Matthias Ehrhardt , Moulay Rchid Sidi Ammi

Accurate epidemic forecasting is critical for informing public health decisions and timely interventions. While Physics-Informed Neural Networks have shown promise in various scientific domains, their potential application to real-time…

Physics and Society · Physics 2026-05-20 Martina Rama , Gabriele Santin , Giulia Cencetti , Michele Tizzoni , Bruno Lepri

When investigating epidemic dynamics through differential models, the parameters needed to understand the phenomenon and to simulate forecast scenarios require a delicate calibration phase, often made even more challenging by the scarcity…

Numerical Analysis · Mathematics 2023-09-11 Giulia Bertaglia , Chuan Lu , Lorenzo Pareschi , Xueyu Zhu

Objective: We propose an end-to-end CNN-based locating model for pulmonary tuberculosis (TB) diagnosis in radiographs. This model makes full use of chest radiograph (X-ray) for its improved accessibility, reduced cost and high accuracy for…

Image and Video Processing · Electrical Eng. & Systems 2019-10-23 Jiwei Liu , Junyu Liu , Yang Liu , Rui Yang , Dongjun Lv , Zhengting Cai , Jingjing Cui

As the COVID-19 pandemic evolves, reliable prediction plays an important role for policy making. The classical infectious disease model SEIR (susceptible-exposed-infectious-recovered) is a compact yet simplistic temporal model. The…

Machine Learning · Computer Science 2020-10-20 Yunling Zheng , Zhijian Li , Jack Xin , Guofa Zhou

Longitudinal analysis in medical imaging is crucial to investigate the progressive changes in anatomical structures or disease progression over time. In recent years, a novel class of algorithms has emerged with the goal of learning disease…

Modeling dynamical biological systems is key for understanding, predicting, and controlling complex biological behaviors. Traditional methods for identifying governing equations, such as ordinary differential equations (ODEs), typically…

Molecular Networks · Quantitative Biology 2024-12-23 Hanna Krasowski , Eric Palanques-Tost , Calin Belta , Murat Arcak

Mechanistic modeling provides a biophysically grounded framework for studying the spread of pathological tau protein in tauopathies like Alzheimer's disease. Existing approaches typically model tau propagation as a diffusive process on the…

Computational Engineering, Finance, and Science · Computer Science 2026-03-18 Nuutti Barron , Heng Rao , Urmi Saha , Yu Gu , Zhenghao Liu , Ge Yu , Defu Yang , Ashish Raj , Minghan Chen

We study a simple model of epidemics where an infected node transmits the infection to its neighbors independently with probability $p$. This is also known as the independent cascade or Susceptible-Infected-Recovered (SIR) model with fixed…

Data Structures and Algorithms · Computer Science 2021-10-19 Yeganeh Alimohammadi , Christian Borgs , Amin Saberi

Neural ordinary differential equations (NODEs), one of the most influential works of the differential equation-based deep learning, are to continuously generalize residual networks and opened a new field. They are currently utilized for…

Machine Learning · Computer Science 2023-12-19 Woojin Cho , Seunghyeon Cho , Hyundong Jin , Jinsung Jeon , Kookjin Lee , Sanghyun Hong , Dongeun Lee , Jonghyun Choi , Noseong Park

Physics informed neural networks (PINNs) have proven to be an efficient tool to represent problems for which measured data are available and for which the dynamics in the data are expected to follow some physical laws. In this paper, we…

Machine Learning · Computer Science 2023-06-14 Fabian Heldmann , Sarah Berkhahn , Matthias Ehrhardt , Kathrin Klamroth

Type 1 Diabetes (T1D) affects millions worldwide, requiring continuous monitoring to prevent severe hypo- and hyperglycemic events. While continuous glucose monitoring has improved blood glucose management, deploying predictive models on…

Machine Learning · Computer Science 2025-11-27 Mirko Paolo Barbato , Giorgia Rigamonti , Davide Marelli , Paolo Napoletano

Off-lattice SIR models are constructed on continuum percolation clusters defined on the Ginibre point process (GPP) and on the Poisson point process (PPP). The static percolation transitions in the continuum percolation models as well as…

Statistical Mechanics · Physics 2021-06-30 Machiko Katori , Makoto Katori

To be fully useful for public health practice, models for epidemic response must be able to do more than predict -- it is also important to incorporate the mechanisms underlying transmission dynamics to enable policymakers and practitioners…

Quantitative Methods · Quantitative Biology 2025-05-26 Jiale Tan , Marisa C. Eisenberg

Background: Mycobacterium Tuberculosis (TB) is an infectious bacterial disease presenting similar symptoms to pneumonia; therefore, differentiating between TB and pneumonia is challenging. Therefore, the main aim of this study is proposing…

Machine Learning · Computer Science 2020-09-07 Toktam Khatibi , Ali Farahani , Hossein Sarmadian

A novel predictive modeling framework for the spread of infectious diseases using high dimensional partial differential equations is developed and implemented. A scalar function representing the infected population is defined on a…

Populations and Evolution · Quantitative Biology 2020-07-06 Sashikumaar Ganesan , Deepak Subramani