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Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to the environment. Current methods for analysis of microbial communities are typically based on taxonomic…

Genomics · Quantitative Biology 2015-12-02 Ehsaneddin Asgari , Kiavash Garakani , Mohammad R. K Mofrad

The performance of sparse matrix computation highly depends on the matching of the matrix format with the underlying structure of the data being computed on. Different sparse matrix formats are suitable for different structures of data.…

Numerical Analysis · Mathematics 2023-09-07 Khaled Abdelaal , Richard Veras

Selecting interpretable feature sets in underdetermined ($n \ll p$) and highly correlated regimes constitutes a fundamental challenge in data science, particularly when analyzing physical measurements. In such settings, multiple distinct…

Machine Learning · Computer Science 2026-02-10 Kateřina Henclová , Václav Šmídl

Simultaneous feature selection and non-linear function estimation is challenging in modeling, especially in high-dimensional settings where the number of variables exceeds the available sample size. In this article, we investigate the…

Machine Learning · Statistics 2026-01-05 Bin Luo , Susan Halabi

Understanding the underlying linguistic rules of plant genomes remains a fundamental challenge in computational biology. Recent advances including AgroNT and PDLLMs have made notable progress although, they suffer from excessive parameter…

Machine Learning · Computer Science 2025-12-09 Kepeng Lin , Qizhe Zhang , Rui Wang , Xuehai Hu , Wei Xu

Partial least squares, as a dimension reduction method, has become increasingly important for its ability to deal with problems with a large number of variables. Since noisy variables may weaken the performance of the model, the sparse…

Methodology · Statistics 2020-06-08 Weijuan Liang , Shuangge Ma , Qingzhao Zhang , Tingyu Zhu

With the development of next generation sequencing technology, researchers have now been able to study the microbiome composition using direct sequencing, whose output are bacterial taxa counts for each microbiome sample. One goal of…

Applications · Statistics 2013-05-24 Jun Chen , Hongzhe Li

In many statistical modeling problems, such as classification and regression, it is common to encounter sparse and blocky coefficients. Sparse fused Lasso is specifically designed to recover these sparse and blocky structured features,…

Statistics Theory · Mathematics 2024-05-30 Xiaofei Wu , Rongmei Liang , Zhimin Zhang , Zhenyu Cui

Sparse regularized regression methods are now widely used in genome-wide association studies (GWAS) to address the multiple testing burden that limits discovery of potentially important predictors. Linear mixed models (LMMs) have become an…

Methodology · Statistics 2022-06-27 Julien St-Pierre , Karim Oualkacha , Sahir Rai Bhatnagar

Sparse modelling or model selection with categorical data is challenging even for a moderate number of variables, because one parameter is roughly needed to encode one category or level. The Group Lasso is a well known efficient algorithm…

Methodology · Statistics 2022-11-14 Szymon Nowakowski , Piotr Pokarowski , Wojciech Rejchel , Agnieszka Sołtys

The structure of biological neural circuits-modular, hierarchical, and sparsely interconnected-reflects an efficient trade-off between wiring cost, functional specialization, and robustness. These principles offer valuable insights for…

Machine Learning · Computer Science 2025-09-23 Orestis Konstantaropoulos , Stelios Manolis Smirnakis , Maria Papadopouli

We introduce a methodology to construct parsimonious probabilistic models. This method makes use of Information Filtering Networks to produce a robust estimate of the global sparse inverse covariance from a simple sum of local inverse…

Information Theory · Computer Science 2017-02-21 Wolfram Barfuss , Guido Previde Massara , T. Di Matteo , Tomaso Aste

One of the fundamental tasks of science is to find explainable relationships between observed phenomena. One approach to this task that has received attention in recent years is based on probabilistic graphical modelling with sparsity…

Machine Learning · Statistics 2014-04-16 Peter Orchard , Felix Agakov , Amos Storkey

We applied a method of compressed sensing to the observation of quasi-particle interference (QPI) by scanning tunneling microscopy/spectroscopy to improve efficiency and save measurement time. To solve an ill-posed problem owing to the…

Mesoscale and Nanoscale Physics · Physics 2016-08-24 Yoshinori Nakanishi-Ohno , Masahiro Haze , Yasuo Yoshida , Koji Hukushima , Yukio Hasegawa , Masato Okada

Accurate inference from quartz crystal microbalance (QCM) measurements in liquids is often limited by reducing resonance behavior to two scalar endpoints (frequency and dissipation shifts, $\Delta f$ and $\Delta D$) or by relying on…

Signal Processing · Electrical Eng. & Systems 2026-04-28 Ceyhun Kirimli , Elcim Elgun , Yagmur Tugtag

We consider the problem of mixed sparse linear regression with two components, where two real $k$-sparse signals $\beta_1, \beta_2$ are to be recovered from $n$ unlabelled noisy linear measurements. The sparsity is allowed to be sublinear…

Machine Learning · Statistics 2023-07-07 Gabriel Arpino , Ramji Venkataramanan

The multivariate regression interpretation of the Gaussian chain graph model simultaneously parametrizes (i) the direct effects of $p$ predictors on $q$ outcomes and (ii) the residual partial covariances between pairs of outcomes. We…

Methodology · Statistics 2024-03-28 Yunyi Shen , Claudia Solís-Lemus , Sameer K. Deshpande

Network estimation and variable selection have been extensively studied in the statistical literature, but only recently have those two challenges been addressed simultaneously. In this paper, we seek to develop a novel method to…

Methodology · Statistics 2024-06-11 Nathan Osborne , Christine B. Peterson , Marina Vannucci

Choosing between classical and Bayesian sparse regression methods involves a real trade-off: penalized estimators like Lasso run in milliseconds but give no uncertainty estimates,while Horseshoe and Spike-and-Slab priors produce full…

Machine Learning · Computer Science 2026-05-05 Hao Xiao

The human gut microbiome is associated with a large number of disease etiologies. As such, it is a natural candidate for machine learning based biomarker development for multiple diseases and conditions. The microbiome is often analyzed…

Quantitative Methods · Quantitative Biology 2022-05-16 Shtossel Oshrit , Isakov Haim , Turjeman Sondra , Koren Omry , Louzoun Yoram