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We study a genetic regulatory network model developed to demonstrate that genetic robustness can evolve through stabilizing selection for optimal phenotypes. We report preliminary results on whether such selection could result in a…

Molecular Networks · Quantitative Biology 2010-12-07 Volkan Sevim , Per Arne Rikvold

Context: The effectiveness of data selection approaches in improving the performance of cross project defect prediction(CPDP) has been shown in multiple previous studies. Beside that, replication studies play an important role in the…

Software Engineering · Computer Science 2020-04-22 Seyedrebvar Hosseini , Burak Turhan

In this work, we improve the generative replay in a continual learning setting to perform well on challenging scenarios. Current generative rehearsal methods are usually benchmarked on small and simple datasets as they are not powerful…

Machine Learning · Computer Science 2023-09-20 Valeriya Khan , Sebastian Cygert , Kamil Deja , Tomasz Trzciński , Bartłomiej Twardowski

Retrieval-Augmented Generation (RAG) is increasingly employed in generative AI-driven scientific workflows to integrate rapidly evolving scientific knowledge bases, yet its reliability is frequently compromised by non-determinism in their…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-24 Baiqiang Wang , Dongfang Zhao , Nathan R Tallent , Luanzheng Guo

Sample-efficient online reinforcement learning often uses replay buffers to store experience for reuse when updating the value function. However, uniform replay is inefficient, since certain classes of transitions can be more relevant to…

Machine Learning · Computer Science 2025-05-12 Renhao Wang , Kevin Frans , Pieter Abbeel , Sergey Levine , Alexei A. Efros

ReTest is a novel testing tool for Java applications with a graphical user interface (GUI), combining monkey testing and difference testing. Since this combination sidesteps the oracle problem, it enables the generation of GUI-based…

Software Engineering · Computer Science 2018-02-13 Daniel Kraus

Generative AI is reshaping how software is designed, written, and maintained. Advances in large language models (LLMs) are enabling new development styles - from chat-oriented programming and 'vibe coding' to agentic programming - that can…

Software Engineering · Computer Science 2025-10-14 Vivek Acharya

In genetic studies of complex diseases, the underlying mode of inheritance is often not known. Thus, the most powerful test or other optimal procedure for one model, e.g. recessive, may be quite inefficient if another model, e.g. dominant,…

Statistics Theory · Mathematics 2007-06-13 Gang Zheng , Boris Freidlin , Joseph L. Gastwirth

The aim of this paper is two-fold. First, we propose a new computational method to investigate the particularities of evolution. Second, we apply this method to a model of gene regulatory networks (GRNs) and explore the evolution of…

Molecular Networks · Quantitative Biology 2022-01-21 Tadamune Kaneko , Macoto Kikuchi

Generative Adversarial Networks (GANs) are an adversarial model that achieved impressive results on generative tasks. In spite of the relevant results, GANs present some challenges regarding stability, making the training usually a…

Neural and Evolutionary Computing · Computer Science 2021-02-02 Victor Costa , Nuno Lourenço , João Correia , Penousal Machado

The tendency of repeating past choices more often than expected from the history of outcomes has been repeatedly empirically observed in reinforcement learning experiments. It can be explained by at least two computational processes:…

Neural and Evolutionary Computing · Computer Science 2024-10-28 Isabelle Hoxha , Leo Sperber , Stefano Palminteri

In genetic programming, an evolutionary method for producing computer programs that solve specified computational problems, parent selection is ordinarily based on aggregate measures of performance across an entire training set. Lexicase…

Neural and Evolutionary Computing · Computer Science 2021-06-14 Thomas Helmuth , Lee Spector

One of the purported ways to increase productivity and reduce development time is to reuse existing features and modules. If reuse is adopted, logically then, it will have a direct impact on a system's evolution. However, the evidence in…

Software Engineering · Computer Science 2021-04-06 Amjed Tahir , Sherlock A. Licorish , Stephen G. MacDonell

Computer simulations of complex population genetic models are an essential tool for making sense of the large-scale datasets of multiple genome sequences from a single species that are becoming increasingly available. A widely used approach…

Populations and Evolution · Quantitative Biology 2026-04-23 Parul Johri , Fanny Pouyet , Brian Charlesworth

Deep neural networks excel at image classification, but their performance is far less robust to input perturbations than human perception. In this work we explore whether this shortcoming may be partly addressed by incorporating…

Computer Vision and Pattern Recognition · Computer Science 2021-11-05 Bhavin Choksi , Milad Mozafari , Callum Biggs O'May , Benjamin Ador , Andrea Alamia , Rufin VanRullen

Ensuring the reproducibility of scientific work is crucial as it allows the consistent verification of scientific claims and facilitates the advancement of knowledge by providing a reliable foundation for future research. However,…

Software Engineering · Computer Science 2025-04-14 Lázaro Costa , Susana Barbosa , Jácome Cunha

Hard constraints in generative sampling are typically enforced by projection, applied either once at the end of sampling or after every update. This binary framing overlooks a fundamental issue: projection changes the distribution of states…

Machine Learning · Computer Science 2026-05-13 Noah Trupin , Yexiang Xue

Despite the widespread availability of generative AI tools in software engineering, developer adoption remains uneven. This unevenness is problematic because it hampers productivity efforts, frustrates management's expectations, and creates…

This paper concerns the problem of how to learn to grasp dexterously, so as to be able to then grasp novel objects seen only from a single view-point. Recently, progress has been made in data-efficient learning of generative grasp models…

Robotics · Computer Science 2019-07-16 Marek Kopicki , Dominik Belter , Jeremy L. Wyatt

Protein fitness optimization involves finding a protein sequence that maximizes desired quantitative properties in a combinatorially large design space of possible sequences. Recent advances in steering protein generative models (e.g.,…

Biomolecules · Quantitative Biology 2025-10-22 Jason Yang , Wenda Chu , Daniel Khalil , Raul Astudillo , Bruce J. Wittmann , Frances H. Arnold , Yisong Yue