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This paper presents a new modeling strategy for joint unsupervised analysis of multiple high-throughput biological studies. As in Multi-study Factor Analysis, our goals are to identify both common factors shared across studies and…

Applications · Statistics 2018-06-27 Roberta De Vito , Ruggero Bellio , Lorenzo Trippa , Giovanni Parmigiani

High-dimensional mediation analysis aims to identify mediating pathways and to estimate indirect effects linking an exposure to an outcome. In this paper, we propose a Bayesian framework to address key challenges in these analyses,…

Methodology · Statistics 2026-02-13 Youngho Bae , Chanmin Kim , Fenglei Wang , Qi Sun , Kyu Ha Lee

Risk-adapted breast cancer screening requires robust models that leverage longitudinal imaging data. Most current deep learning models use single or limited prior mammograms and lack adaptation for real-world settings marked by imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Manel Rakez , Thomas Louis , Julien Guillaumin , Foucauld Chamming's , Pierre Fillard , Brice Amadeo , Virginie Rondeau

Accurate gene regulatory networks can be used to explain the emergence of different phenotypes, disease mechanisms, and other biological functions. Many methods have been proposed to infer networks from gene expression data but have been…

Quantitative Methods · Quantitative Biology 2018-12-11 Phan Nguyen , Rosemary Braun

Adaptive or dynamic signal sampling in sensing systems can adapt subsequent sampling strategies based on acquired signals, thereby potentially improving image quality and speed. This paper proposes a Bayesian method for adaptive sampling…

Signal Processing · Electrical Eng. & Systems 2023-02-28 Guanhua Wang , Douglas C. Noll , Jeffrey A. Fessler

In this paper, we introduce the Generalized Mixed Regularized Reduced Rank Regression model (GMR4), an extension of the GMR3 model designed to improve performance in high-dimensional settings. GMR3 is a regression method for a mix of…

Methodology · Statistics 2025-12-16 Lorenza Cotugno , Mark de Rooij , Roberta Siciliano

We propose a novel method that performs adaptive clustering with DPMM using collapsed VI, while incorporating weakly-informative priors for DP concentration parameter alpha and base distribution G0. We illustrate the importance of G0…

Methodology · Statistics 2026-02-19 Annesh Pal , Aguirre Mimoun , Rodolphe Thiébaut , Boris P. Hejblum

Penalization schemes like Lasso or ridge regression are routinely used to regress a response of interest on a high-dimensional set of potential predictors. Despite being decisive, the question of the relative strength of penalization is…

Methodology · Statistics 2018-11-08 Britta Velten , Wolfgang Huber

As large language models (LLMs) continue to be deployed and utilized across domains, the volume of LLM-generated data is growing rapidly. This trend highlights the increasing importance of effective and lossless compression for such data in…

Machine Learning · Computer Science 2025-05-13 Yu Mao , Holger Pirk , Chun Jason Xue

Large-scale {\it in vitro} drug sensitivity screens are an important tool in personalized oncology to predict the effectiveness of potential cancer drugs. The prediction of the sensitivity of cancer cell lines to a panel of drugs is a…

Methodology · Statistics 2020-03-10 Zhi Zhao , Manuela Zucknick

Additive smooth models, such as Generalized additive models (GAMs) of location, scale, and shape (GAMLSS), are a popular choice for modeling experimental data. However, software available to fit such models is usually not tailored…

Methodology · Statistics 2025-06-17 Joshua Krause , Jelmer P. Borst , Jacolien van Rij

We propose generalized additive partial linear models for complex data which allow one to capture nonlinear patterns of some covariates, in the presence of linear components. The proposed method improves estimation efficiency and increases…

Statistics Theory · Mathematics 2014-05-26 Li Wang , Lan Xue , Annie Qu , Hua Liang

In this paper we develop inference for high dimensional linear models, with serially correlated errors. We examine Lasso under the assumption of strong mixing in the covariates and error process, allowing for fatter tails in their…

Econometrics · Economics 2023-10-05 Ilias Chronopoulos , Katerina Chrysikou , George Kapetanios

The Lasso regression is a popular regularization method for feature selection in statistics. Prior to computing the Lasso estimator in both linear and generalized linear models, it is common to conduct a preliminary rescaling of the feature…

Methodology · Statistics 2023-11-21 Anant Mathur , Sarat Moka , Zdravko Botev

We develop an extension of the classical Zellner's g-prior to generalized linear models. The prior on the hyperparameter g is handled in a flexible way, so that any continuous proper hyperprior f(g) can be used, giving rise to a large class…

Methodology · Statistics 2011-09-05 Daniel Sabanés Bové , Leonhard Held

The paper proposes a new algorithm for the high-dimensional financial data -- the Groupwise Interpretable Basis Selection (GIBS) algorithm, to estimate a new Adaptive Multi-Factor (AMF) asset pricing model, implied by the recently developed…

Statistical Finance · Quantitative Finance 2021-12-14 Liao Zhu , Sumanta Basu , Robert A. Jarrow , Martin T. Wells

The training of high-dimensional regression models on comparably sparse data is an important yet complicated topic, especially when there are many more model parameters than observations in the data. From a Bayesian perspective, inference…

Methodology · Statistics 2025-03-03 Javier Enrique Aguilar , Paul-Christian Bürkner

Since most inverse problems arising in scientific and engineering applications are ill-posed, prior information about the solution space is incorporated, typically through regularization, to establish a well-posed problem with a unique…

Signal Processing · Electrical Eng. & Systems 2024-06-18 Carter Lyons , Raghu G. Raj , Margaret Cheney

Recent research has demonstrated that feature attribution methods for deep networks can themselves be incorporated into training; these attribution priors optimize for a model whose attributions have certain desirable properties -- most…

Machine Learning · Computer Science 2020-11-12 Gabriel Erion , Joseph D. Janizek , Pascal Sturmfels , Scott Lundberg , Su-In Lee

Estimation in generalized linear models (GLM) is complicated by the presence of constraints. One can handle constraints by maximizing a penalized log-likelihood. Penalties such as the lasso are effective in high dimensions, but often lead…

Machine Learning · Statistics 2017-11-07 Jason Xu , Eric C. Chi , Kenneth Lange