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Synthetic data generation in histopathology faces unique challenges: preserving tissue heterogeneity, capturing subtle morphological features, and scaling to unannotated datasets. We present a latent diffusion model that generates realistic…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Saghir Alfasly , Wataru Uegami , MD Enamul Hoq , Ghazal Alabtah , H. R. Tizhoosh

CNNs have been widely applied for medical image analysis. However, limited memory capacity is one of the most common drawbacks of processing high-resolution 3D volumetric data. 3D volumes are usually cropped or downsized first before…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Nyothiri Aung , Tahar Kechadi , Liming Chen , Sahraoui Dhelim

This paper introduces a network for volumetric segmentation that learns from sparsely annotated volumetric images. We outline two attractive use cases of this method: (1) In a semi-automated setup, the user annotates some slices in the…

Computer Vision and Pattern Recognition · Computer Science 2016-06-22 Özgün Çiçek , Ahmed Abdulkadir , Soeren S. Lienkamp , Thomas Brox , Olaf Ronneberger

Scaling up model size and training data has advanced foundation models for instance-level perception, achieving state-of-the-art in-domain and zero-shot performance across object detection and segmentation. However, their high computational…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Mattia Segu , Marta Tintore Gazulla , Yongqin Xian , Luc Van Gool , Federico Tombari

Understanding the kinetics of drug-protein interactions is paramount for drug design, yet the field lacks large-scale, dynamic data to move beyond static structural analysis. Here, we present DD-03B, a massively scalable database providing…

Computational Physics · Physics 2026-04-09 Maodong Li , Dechin Chen , Zhijun Pan , Zhe Wang , Yi Isaac Yang

The mature soybean plants are of complex architecture with pods frequently touching each other, posing a challenge for in-situ segmentation of on-branch soybean pods. Deep learning-based methods can achieve accurate training and strong…

Computer Vision and Pattern Recognition · Computer Science 2022-04-27 Si Yang , Lihua Zheng , Xieyuanli Chen , Laura Zabawa , Man Zhang , Minjuan Wang

Falls represent a significant cause of injury among the elderly population. Extensive research has been devoted to the utilization of wearable IMU sensors in conjunction with machine learning techniques for fall detection. To address the…

Quantitative Methods · Quantitative Biology 2023-10-18 Jie Tang , Bin He , Junkai Xu , Tian Tan , Zhipeng Wang , Yanmin Zhou , Shuo Jiang

Data-driven methods such as convolutional neural networks (CNNs) are known to deliver state-of-the-art performance on image recognition tasks when the training data are abundant. However, in some instances, such as change detection in…

Computer Vision and Pattern Recognition · Computer Science 2019-05-21 Maria Kolos , Anton Marin , Alexey Artemov , Evgeny Burnaev

A key limitation of deep convolutional neural networks (DCNN) based image segmentation methods is the lack of generalizability. Manually traced training images are typically required when segmenting organs in a new imaging modality or from…

Computer Vision and Pattern Recognition · Computer Science 2019-10-01 Yuankai Huo , Zhoubing Xu , Hyeonsoo Moon , Shunxing Bao , Albert Assad , Tamara K. Moyo , Michael R. Savona , Richard G. Abramson , Bennett A. Landman

Generalist biomedical image segmentation models such as Cellpose are increasingly applied across diverse imaging modalities and cell types. However, two critical challenges remain underexplored: (1) the extent of training data redundancy…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Shuo Zhao , Jianxu Chen

Existing 3D instance segmentation methods are predominated by the bottom-up design -- manually fine-tuned algorithm to group points into clusters followed by a refinement network. However, by relying on the quality of the clusters, these…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Tuan Duc Ngo , Binh-Son Hua , Khoi Nguyen

The performance of deep neural networks is strongly influenced by the quality of their training data. However, mitigating dataset bias by manually curating challenging edge cases remains a major bottleneck. To address this, we propose an…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kyeongryeol Go

The use of machine learning (ML) methods for development of robust and flexible visual inspection system has shown promising. However their performance is highly dependent on the amount and diversity of training data. This is often…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Juraj Fulir , Natascha Jeziorski , Lovro Bosnar , Hans Hagen , Claudia Redenbach , Petra Gospodnetić , Tobias Herrfurth , Marcus Trost , Thomas Gischkat

Foundation models for interactive segmentation in 2D natural images and videos have sparked significant interest in building 3D foundation models for medical imaging. However, the domain gaps and clinical use cases for 3D medical imaging…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Yufan He , Pengfei Guo , Yucheng Tang , Andriy Myronenko , Vishwesh Nath , Ziyue Xu , Dong Yang , Can Zhao , Benjamin Simon , Mason Belue , Stephanie Harmon , Baris Turkbey , Daguang Xu , Wenqi Li

We introduce EvObj for unsupervised 3D instance segmentation that bridges the geometric domain gap between synthetic pretraining data and real-world point clouds. Current methods suffer from structural discrepancies when transferring object…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Jiahao Chen , Zihui Zhang , Yafei Yang , Jinxi Li , Shenxing Wei , Zhixuan Sun , Bo Yang

Pseudo-healthy synthesis is the task of creating a subject-specific `healthy' image from a pathological one. Such images can be helpful in tasks such as anomaly detection and understanding changes induced by pathology and disease. In this…

Image and Video Processing · Electrical Eng. & Systems 2021-06-21 Tian Xia , Agisilaos Chartsias , Sotirios A. Tsaftaris

Surgical planning and training based on machine learning requires a large amount of 3D anatomical models reconstructed from medical imaging, which is currently one of the major bottlenecks. Obtaining these data from real patients and during…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Ann-Sophia Müller , Moonkwang Jeong , Meng Zhang , Jiyuan Tian , Arkadiusz Miernik , Stefanie Speidel , Tian Qiu

Increasing data set sizes of 3D microscopy imaging experiments demand for an automation of segmentation processes to be able to extract meaningful biomedical information. Due to the shortage of annotated 3D image data that can be used for…

Image and Video Processing · Electrical Eng. & Systems 2022-02-02 Dennis Eschweiler , Richard S. Smith , Johannes Stegmaier

Nuclei segmentation and classification is a significant process in pathology image analysis. Deep learning-based approaches have greatly contributed to the higher accuracy of this task. However, those approaches suffer from the imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Hyun-Jic Oh , Won-Ki Jeong

Segmentation of structural parts of 3D models of plants is an important step for plant phenotyping, especially for monitoring architectural and morphological traits. Current state-of-the art approaches rely on hand-crafted 3D local features…

Computer Vision and Pattern Recognition · Computer Science 2022-02-24 Kaya Turgut , Helin Dutagaci , Gilles Galopin , David Rousseau