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Related papers: CURA: Clinical Uncertainty Risk Alignment for Lang…

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This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Clinical dataset labels are rarely certain as annotators disagree and confidence is not uniform across cases. Typical aggregation procedures, such as majority voting, obscure this variability. In simple experiments on medical imaging…

Uncertainty estimation is a significant issue for current large language models (LLMs) that are generally poorly calibrated and over-confident, especially with reinforcement learning from human feedback (RLHF). Unlike humans, whose…

Computation and Language · Computer Science 2024-05-13 Ruixin Yang , Dheeraj Rajagopal , Shirley Anugrah Hayati , Bin Hu , Dongyeop Kang

Large language models (LLMs) are increasingly employed in information-seeking and decision-making tasks. Despite their broad utility, LLMs tend to generate information that conflicts with real-world facts, and their persuasive style can…

Computation and Language · Computer Science 2024-09-19 Arslan Chaudhry , Sridhar Thiagarajan , Dilan Gorur

Large language models (LLMs) are increasingly used in high-stakes settings, where overconfident responses can mislead users. Reliable confidence estimation has been shown to enhance trust and task accuracy. Yet existing methods face…

Computation and Language · Computer Science 2025-09-30 Linwei Tao , Yi-Fan Yeh , Bo Kai , Minjing Dong , Tao Huang , Tom A. Lamb , Jialin Yu , Philip H. S. Torr , Chang Xu

Whether learned, simulated, or analytical, approximations of a robot's dynamics can be inaccurate when encountering novel environments. Many approaches have been proposed to quantify the aleatoric uncertainty of such methods, i.e.…

Robotics · Computer Science 2025-03-14 Luís Marques , Dmitry Berenson

Large Language and Vision-Language Models (LLMs/VLMs) are increasingly used in safety-critical applications, yet their opaque decision-making complicates risk assessment and reliability. Uncertainty quantification (UQ) helps assess…

Machine Learning · Computer Science 2025-02-12 Sina Tayebati , Divake Kumar , Nastaran Darabi , Dinithi Jayasuriya , Ranganath Krishnan , Amit Ranjan Trivedi

We introduce AcuityBench, a benchmark for evaluating whether language models identify the appropriate urgency of care from user medical presentations. Existing health benchmarks emphasize medical question answering, broad health…

Large language models (LLMs) often produce confident yet incorrect responses, and uncertainty quantification is one potential solution to more robust usage. Recent works routinely rely on self-consistency to estimate aleatoric uncertainty…

Artificial Intelligence · Computer Science 2026-04-21 Kimia Hamidieh , Veronika Thost , Walter Gerych , Mikhail Yurochkin , Marzyeh Ghassemi

In text classification tasks, models often rely on spurious correlations for predictions, incorrectly associating irrelevant features with the target labels. This issue limits the robustness and generalization of models, especially when…

Machine Learning · Computer Science 2025-02-04 Yuqing Zhou , Ziwei Zhu

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Automatic radiology report generation has attracted enormous research interest due to its practical value in reducing the workload of radiologists. However, simultaneously establishing global correspondences between the image (e.g., Chest…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Yaowei Li , Bang Yang , Xuxin Cheng , Zhihong Zhu , Hongxiang Li , Yuexian Zou

Combinatorial medication recommendation(CMR) is a fundamental task of healthcare, which offers opportunities for clinical physicians to provide more precise prescriptions for patients with intricate health conditions, particularly in the…

Artificial Intelligence · Computer Science 2025-01-14 Jie Tan , Yu Rong , Kangfei Zhao , Tian Bian , Tingyang Xu , Junzhou Huang , Hong Cheng , Helen Meng

The application of Deep Learning in medical diagnosis must balance patient safety with compliance with data protection regulations. Machine Unlearning enables the selective removal of training data from deployed models. However, most…

Artificial Intelligence · Computer Science 2026-04-28 Andreza M. C. Falcao , Filipe R. Cordeiro

Deploying large language models for clinical Text-to-SQL requires distinguishing two qualitatively different causes of output diversity: (i) input ambiguity that should trigger clarification, and (ii) model instability that should trigger…

Computation and Language · Computer Science 2026-05-19 Angelo Ziletti , Leonardo D'Ambrosi

Large-scale EHR prediction across institutions is hindered by substantial heterogeneity in schemas and code systems. Although Common Data Models (CDMs) can standardize records for multi-institutional learning, the manual harmonization and…

Computation and Language · Computer Science 2026-04-02 Kyunghoon Hur , Heeyoung Kwak , Jinsu Jang , Nakhwan Kim , Edward Choi

Conformal prediction (CP) and its extension, conformal risk control (CRC), are established frameworks for quantifying uncertainty in supervised machine learning through formal guarantees. However, recent breakthroughs in artificial…

Machine Learning · Computer Science 2026-05-29 Gabriel Loaiza-Ganem , Kevin Zhang , Wei Cui , Marc T. Law , Kin Kwan Leung

The calibration of a measurement device is crucial for every scientific experiment, where a signal has to be inferred from data. We present CURE, the calibration uncertainty renormalized estimator, to reconstruct a signal and simultaneously…

Data Analysis, Statistics and Probability · Physics 2015-03-03 Sebastian Dorn , Torsten A. Enßlin , Maksim Greiner , Marco Selig , Vanessa Boehm

Computer-aided diagnosis systems must make critical decisions from medical images that are often noisy, ambiguous, or conflicting, yet today's models are trained on overly simplistic labels that ignore diagnostic uncertainty. One-hot labels…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Ang Nan Gu , Michael Tsang , Hooman Vaseli , Purang Abolmaesumi , Teresa Tsang

Data following an interval structure are increasingly prevalent in many scientific applications. In medicine, clinical events are often monitored between two clinical visits, making the exact time of the event unknown and generating…

Methodology · Statistics 2025-04-01 Carlos García Meixide , Michael R. Kosorok , Marcos Matabuena
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