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Recent development in quantum information sciences and technologies, especially building programmable quantum computers, provide us new opportunities to study fundamental aspects of quantum mechanics. We propose qubit models to emulate the…

Quantum Physics · Physics 2022-06-29 Meng-Jun Hu , Yanbei Chen , Yiqiu Ma , Xiang Li , Yubao Liu , Yong-Sheng Zhang , Haixing Miao

In structure-based virtual screening, it is often necessary to evaluate the binding free energy of protein-ligand complexes by considering not only molecular conformations but also how these structures shift and rotate in space. The number…

Quantum Physics · Physics 2025-07-25 Pei-Kun Yang

The implementation and practicality of quantum algorithms highly hinge on the quality of operations within a quantum processor. Therefore, including realistic error models in quantum computing simulation platforms is crucial for testing…

Quantum Physics · Physics 2021-04-12 Ahmed Abid Moueddene , Nader Khammassi , Koen Bertels , Carmen G. Almudever

The emergence of Next Generation Sequencing (NGS) platforms has increased the throughput of genomic sequencing and in turn the amount of data that needs to be processed, requiring highly efficient computation for its analysis. In this…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-12-12 Nicola Cadenelli , Jorda Polo , David Carrera

In recent years, quantum machine learning (QML) has been actively used for various tasks, e.g., classification, reinforcement learning, and adversarial learning. However, these QML studies are unable to carry out complex tasks due to…

Quantum Physics · Physics 2022-11-15 Won Joon Yun , Hankyul Baek , Joongheon Kim

While various models and computational tools have been proposed for structure and property analysis of molecules, generating molecules that conform to all desired structures and properties remains a challenge. Here, we introduce a…

Computation and Language · Computer Science 2024-10-11 Peng Zhou , Jianmin Wang , Chunyan Li , Zixu Wang , Yiping Liu , Siqi Sun , Jianxin Lin , Leyi Wei , Xibao Cai , Houtim Lai , Wei Liu , Longyue Wang , Yuansheng Liu , Xiangxiang Zeng

Neural network potentials (NNPs) enable large-scale molecular dynamics (MD) simulations of systems containing >10,000 atoms with the accuracy comparable to ab initio methods and play a crucial role in material studies. Although NNPs are…

Quantum computer emulators model the behavior and error rates of specific quantum processors. Without accurate noise models in these emulators, it is challenging for users to optimize and debug executable quantum programs prior to running…

Quantum Physics · Physics 2026-05-20 Matthew Ho , Jun Yong Khoo , Adrian M. Mak , Stefano Carrazza

The exact evaluation of the molecular ground state in quantum chemistry requires an exponentially increasing computational cost. Quantum computation is a promising way to overcome the exponential problem using polynomial-time quantum…

Quantum Physics · Physics 2023-05-30 Changsu Cao , Jiaqi Hu , Wengang Zhang , Xusheng Xu , Dechin Chen , Fan Yu , Jun Li , Hanshi Hu , Dingshun Lv , Man-Hong Yung

Quantum computing holds promise for revolutionizing computational chemistry simulations, particularly in drug discovery. However, current quantum hardware is limited by noise and scale, necessitating bridging technologies. This study…

Quantum Physics · Physics 2025-04-16 Marek Kowalik , Ellen Michael , Peter Pogány , Phalgun Lolur

With the advent of high-performance computing techniques, the data for analysis has grown significantly. Here, graphic processing unit (GPU) based program kernels are discussed to exploit parallelism in the analysis codes specific to…

Computational Physics · Physics 2018-11-07 Gourav Shrivastav , Manish Agarwal

We present a novel Adaptive Distribution Generator that leverages a quantum walks-based approach to generate high precision and efficiency of target probability distributions. Our method integrates variational quantum circuits with…

Quantum Physics · Physics 2026-04-10 Yen-Jui Chang , Wei-Ting Wang , Chen-Yu Liu , Yun-Yuan Wang , Ching-Ray Chang

State Space Models (SSMs) are emerging as a compelling alternative to Transformers because of their consistent memory usage and high performance. Despite this, scaling up SSMs on cloud services or limited-resource devices is challenging due…

Machine Learning · Computer Science 2025-11-07 Hung-Yueh Chiang , Chi-Chih Chang , Natalia Frumkin , Kai-Chiang Wu , Mohamed S. Abdelfattah , Diana Marculescu

Sampling from the stationary distribution is one of the fundamental tasks of Markov chain-based algorithms and has important applications in machine learning, combinatorial optimization and network science. For the quantum case, qsampling…

Quantum Physics · Physics 2023-03-08 Xinyin Li , Yun Shang

Quantum centric supercomputing (QCSC) framework, such as sample-based quantum diagonalization (SQD) holds immense promise toward achieving practical quantum utility to solve challenging problems. QCSC leverages quantum computers to perform…

We propose an approach for learning probability distributions as differentiable quantum circuits (DQC) that enable efficient quantum generative modelling (QGM) and synthetic data generation. Contrary to existing QGM approaches, we perform…

Quantum Physics · Physics 2024-11-15 Oleksandr Kyriienko , Annie E. Paine , Vincent E. Elfving

Connecting multiple smaller qubit modules by generating high-fidelity entangled states is a promising path for scaling quantum computing hardware. The performance of such a modular quantum computer is highly dependent on the quality and…

Neutral atoms are among the leading platforms toward realizing fault-tolerant quantum computation (FTQC). However, scaling up a single neutral-atom device beyond $\sim 10^4$ atoms to meet the demands of FTQC for practical applications…

Quantum Physics · Physics 2025-02-18 Shinichi Sunami , Shiro Tamiya , Ryotaro Inoue , Hayata Yamasaki , Akihisa Goban

Quantum random access memory (QRAM) enables efficient classical data access for quantum computers -- a prerequisite for many quantum algorithms to achieve quantum speedup. Despite various proposals, the experimental realization of QRAM…

The frontier of quantum computing (QC) simulation on classical hardware is quickly reaching the hard scalability limits for computational feasibility. Nonetheless, there is still a need to simulate large quantum systems classically, as the…

Quantum Physics · Physics 2025-06-23 Marzio Vallero , Flavio Vella , Paolo Rech