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The active-space quantum chemical methods could provide very accurate description of strongly correlated electronic systems, which is of tremendous value for natural sciences. The proper choice of the active space is crucial, but a…

Chemical Physics · Physics 2020-12-01 Pavlo Golub , Andrej Antalik , Libor Veis , Jiri Brabec

A new approach for efficiently exploring the configuration space and computing the free energy of large atomic and molecular systems is proposed, motivated by an analogy with reinforcement learning. There are two major components in this…

Chemical Physics · Physics 2018-04-18 Linfeng Zhang , Han Wang , Weinan E

Nowadays, Neural Networks represent a major expectation for the realization of powerful Deep Learning algorithms, which can determine several physical systems' behaviors and operations. Computational resources required for model, training,…

Machine Learning · Computer Science 2021-03-02 Giulia Crocioni , Giambattista Gruosso , Danilo Pau , Davide Denaro , Luigi Zambrano , Giuseppe di Giore

As vast databases of chemical identities become increasingly available, the challenge shifts to how we effectively explore and leverage these resources to study molecular properties. This paper presents an active learning approach for…

Machine Learning · Computer Science 2025-07-17 Ayana Ghosh , Maxim Ziatdinov , Sergei V. Kalinin

Machine learning potentials (MLPs) have advanced rapidly and show great promise to transform molecular dynamics (MD) simulations. However, most existing software tools are tied to specific MLP architectures, lack integration with standard…

Computational Physics · Physics 2025-06-05 Paul Fuchs , Weilong Chen , Stephan Thaler , Julija Zavadlav

Machine learning methods have shown promise in predicting molecular properties, and given sufficient training data machine learning approaches can enable rapid high-throughput virtual screening of large libraries of compounds. Graph-based…

Accurate free energy representations are crucial for understanding phase dynamics in materials. We employ a scale-bridging approach to incorporate atomistic information into our free energy model by training a neural network on DFT-informed…

Computational Physics · Physics 2025-03-12 Jamie Holber , Krishna Garikipati

The use of machine learning interatomic potentials (MLIPs) in simulations of materials is a state-of-the-art approach, which allows achieving nearly \textit{ab initio} accuracy with orders of magnitude less computational cost.…

Materials Science · Physics 2021-10-28 R. E. Ryltsev , N. M. Chtchelkatchev

Scaling up deep neural network capacity has been known as an effective approach to improving model quality for several different machine learning tasks. In many cases, increasing model capacity beyond the memory limit of a single…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Yanping Huang , Youlong Cheng , Ankur Bapna , Orhan Firat , Mia Xu Chen , Dehao Chen , HyoukJoong Lee , Jiquan Ngiam , Quoc V. Le , Yonghui Wu , Zhifeng Chen

Modern machine learning systems based on neural networks have shown great success in learning complex data patterns while being able to make good predictions on unseen data points. However, the limited interpretability of these systems…

Machine Learning · Computer Science 2020-07-22 Sarath Shekkizhar , Antonio Ortega

Machine-learned coarse-grained (CG) models often suffer from noisy training data, limiting their accuracy and transferability. We propose a method to generate low-noise training data based on the potential of mean force by constraining CG…

Computational Physics · Physics 2026-03-03 Zheyong Fan , Wenjun Zhang , Zhenhao Zhang , Ke Xu , Xuecheng Shao , Haikuan Dong

Molecular mechanics (MM) potentials have long been a workhorse of computational chemistry. Leveraging accuracy and speed, these functional forms find use in a wide variety of applications in biomolecular modeling and drug discovery, from…

While molecular dynamics (MD) is a very useful computational method for atomistic simulations, modeling the interatomic interactions for reliable MD simulations of real materials has been a long-standing challenge. In 2007, Behler and…

Materials Science · Physics 2025-06-11 Ling Tang , Weiyi Xia , Gayatri Viswanathan , Ernesto Soto , Kirill Kovnir , Cai-Zhuang Wang

The sustainable production of many bulk chemicals relies on heterogeneous catalysis. The rational design or improvement of the required catalysts critically depends on insights into the underlying mechanisms at the atomic scale. In recent…

Chemical Physics · Physics 2024-11-04 Amir Omranpour , Jan Elsner , K. Nikolas Lausch , Jörg Behler

Machine learning of the quantitative relationship between local environment descriptors and the potential energy surface of a system of atoms has emerged as a new frontier in the development of interatomic potentials (IAPs). Here, we…

Machine learning assisted modeling of the inter-atomic potential energy surface (PES) is revolutionizing the field of molecular simulation. With the accumulation of high-quality electronic structure data, a model that can be pretrained on…

Chemical Physics · Physics 2023-09-18 Duo Zhang , Hangrui Bi , Fu-Zhi Dai , Wanrun Jiang , Linfeng Zhang , Han Wang

Solidification governs the microstructure and, therefore, the mechanical response of metal components, yet the atomistic details of nucleation and defect formation are often difficult to determine experimentally. Molecular dynamics can…

Computational Physics · Physics 2026-03-26 Ian Störmer , Julija Zavadlav

Scaling model capacity has been vital in the success of deep learning. For a typical network, necessary compute resources and training time grow dramatically with model size. Conditional computation is a promising way to increase the number…

Machine Learning · Computer Science 2018-11-14 Louis Kirsch , Julius Kunze , David Barber

High annotation cost for training machine learning classifiers has driven extensive research in active learning and self-supervised learning. Recent research has shown that in the context of supervised learning different active learning…

Machine Learning · Computer Science 2023-06-08 Ziting Wen , Oscar Pizarro , Stefan Williams

We demonstrate how an evolutionary algorithm can be extended with a curriculum learning process that selects automatically the environmental conditions in which the evolving agents are evaluated. The environmental conditions are selected so…

Neural and Evolutionary Computing · Computer Science 2021-02-18 Nicola Milano , Stefano Nolfi