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Machine-Learning Interatomic Potentials (MLIPs) have surged in popularity due to their promise of expanding the spatiotemporal scales possible for simulating molecules with high fidelity. The accuracy of any MLIP is dependent on the data…

Soft Condensed Matter · Physics 2026-02-27 Natalie E. Hooven , Arthur Y. Lin , Charles H. Carroll , Rose K. Cersonsky

We introduce a scheme for molecular simulations, the Deep Potential Molecular Dynamics (DeePMD) method, based on a many-body potential and interatomic forces generated by a carefully crafted deep neural network trained with ab initio data.…

Computational Physics · Physics 2018-04-11 Linfeng Zhang , Jiequn Han , Han Wang , Roberto Car , Weinan E

Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of parameters compared to…

Infrared and Raman spectroscopy are widely used for the characterization of gases, liquids, and solids, as the spectra contain a wealth of information concerning in particular the dynamics of these systems. Atomic scale simulations can be…

Mesoscale and Nanoscale Physics · Physics 2024-08-15 Nan Xu , Petter Rosander , Christian Schäfer , Eric Lindgren , Nicklas Österbacka , Mandi Fang , Wei Chen , Yi He , Zheyong Fan , Paul Erhart

Machine learning interatomic potentials (MLIPs) provide an effective approach for accurately and efficiently modeling atomic interactions, expanding the capabilities of atomistic simulations to complex systems. However, a priori feature…

Computational Physics · Physics 2026-04-22 Tina Torabi , Matthias Militzer , Michael P. Friedlander , Christoph Ortner

Machine learning potentials (MLPs) trained on data from quantum-mechanics based first-principles methods can approach the accuracy of the reference method at a fraction of the computational cost. To facilitate efficient MLP-based molecular…

Materials Science · Physics 2021-08-17 Michael S. Chen , Tobias Morawietz , Hideki Mori , Thomas E. Markland , Nongnuch Artrith

Machine learned interatomic potentials, particularly equivariant message-passing (MP) models, have demonstrated high fidelity in representing first-principles data, revolutionizing computational studies in materials science, biophysics, and…

Chemical Physics · Physics 2025-09-01 Yaolong Zhang , Hua Guo

Path-integral molecular dynamics (PIMD) simulations are crucial for accurately capturing nuclear quantum effects in materials. However, their computational intensity and reliance on multiple software packages often limit their applicability…

Machine learning interatomic potentials (MLIPs) enables molecular dynamics (MD) simulations with ab initio accuracy and has been applied to various fields of physical science. However, the performance and transferability of MLIPs are…

Chemical Physics · Physics 2024-04-16 Taoyong Cui , Chenyu Tang , Mao Su , Shufei Zhang , Yuqiang Li , Lei Bai , Yuhan Dong , Xingao Gong , Wanli Ouyang

Generating labeled training datasets has become a major bottleneck in Machine Learning (ML) pipelines. Active ML aims to address this issue by designing learning algorithms that automatically and adaptively select the most informative…

Machine Learning · Computer Science 2020-04-29 Mina Karzand , Robert D. Nowak

We present our ongoing work NeuroMapper, an in-browser visualization tool that helps machine learning (ML) developers interpret the evolution of a model during training, providing a new way to monitor the training process and visually…

Human-Computer Interaction · Computer Science 2022-10-25 Zhiyan Zhou , Kevin Li , Haekyu Park , Megan Dass , Austin Wright , Nilaksh Das , Duen Horng Chau

In recent years, machine learning interatomic potentials (MLIPs) have attracted significant attention as a method that enables large-scale, long-time atomistic simulations while maintaining accuracy comparable to electronic structure…

Materials Science · Physics 2025-03-27 Yuta Yoshimoto , Naoki Matsumura , Yuto Iwasaki , Hiroshi Nakao , Yasufumi Sakai

As a machine-learned potential, the neuroevolution potential (NEP) method features exceptional computational efficiency and has been successfully applied in materials science. Constructing high-quality training datasets is crucial for…

Machine Learning · Computer Science 2025-06-03 Chengbing Chen , Yutong Li , Rui Zhao , Zhoulin Liu , Zheyong Fan , Gang Tang , Zhiyong Wang

The advancement of novel combinatorial CRISPR screening technologies enables the identification of synergistic gene combinations on a large scale. This is crucial for developing novel and effective combination therapies, but the…

Genomics · Quantitative Biology 2024-12-12 Jason Qin , Hans-Hermann Wessels , Carlos Fernandez-Granda , Yuhan Hao

An adaptive modeling method (AMM) that couples a deep neural network potential and a classical force field is introduced to address the accuracy-efficiency dilemma faced by the molecular simulation community. The AMM simulated system is…

Chemical Physics · Physics 2018-11-14 Linfeng Zhang , Han Wang , Weinan E

The capacity of an embodied agent to understand, predict, and interact with its environment is fundamentally contingent on an internal world model. This paper introduces a novel framework for investigating the formation and adaptation of…

Neural and Evolutionary Computing · Computer Science 2025-11-05 Brennen Hill

Neural network (NN) interatomic potentials provide fast prediction of potential energy surfaces, closely matching the accuracy of the electronic structure methods used to produce the training data. However, NN predictions are only reliable…

Machine Learning · Computer Science 2021-08-31 Daniel Schwalbe-Koda , Aik Rui Tan , Rafael Gómez-Bombarelli

The $\text{Cu}_7\text{P}\text{S}_6$ compound has garnered significant attention due to its potential in thermoelectric applications. In this study, we introduce a neuroevolution potential (NEP), trained on a dataset generated from ab initio…

Materials Science · Physics 2024-11-19 Junlan Liu , Qian Yin , Mengshu He , Jun Zhou

An active learning procedure called Deep Potential Generator (DP-GEN) is proposed for the construction of accurate and transferable machine learning-based models of the potential energy surface (PES) for the molecular modeling of materials.…

Computational Physics · Physics 2019-03-06 Linfeng Zhang , De-Ye Lin , Han Wang , Roberto Car , Weinan E

Machine-learned interatomic potentials have revolutionized molecular dynamics simulations by providing quantum-mechanical accuracy at empirical-potential speeds. The graphics processing unit molecular dynamics (GPUMD) package, featuring the…