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Related papers: From Brain Models to Executable Digital Twins: Exe…

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While the digital twin has become an intrinsic part of the product creation process, its true power lies in the connectivity of the digital representation with its physical counterpart. Data acquired on the physical asset can validate,…

Other Computer Science · Computer Science 2023-04-17 Herman Van der Auweraer , Dirk Hartmann

Animal behavior reflects interactions between the nervous system, body, and environment. Therefore, biomechanics and environmental context must be considered to understand algorithms for behavioral control. Neuromechanical digital twins,…

Neurons and Cognition · Quantitative Biology 2026-04-14 Sibo Wang-Chen , Pavan Ramdya

With the accelerating availability of multimodal surgical data and real-time computation, Surgical Digital Twins (SDTs) have emerged as virtual counterparts that mirror, predict, and inform decisions across pre-, intra-, and postoperative…

We propose a synthesis method for the design of digital twins applicable to various systems (pneumatic, hydraulic, electrical/electronic circuits). The methodology allows representing the operation of these systems through an active digital…

Systems and Control · Electrical Eng. & Systems 2024-10-01 Veyis Gunes

We live in a world of exploding complexity driven by technical evolution as well as highly volatile socio-economic environments. Managing complexity is a key issue in everyday decision making such as providing safe, sustainable, and…

Computers and Society · Computer Science 2023-11-28 Dirk Hartmann

Digital twins are sophisticated software systems for the representation, monitoring, and control of cyber-physical systems, including automotive, avionics, smart manufacturing, and many more. Existing definitions and reference models of…

Software Engineering · Computer Science 2025-07-08 Jerome Pfeiffer , Jingxi Zhang , Benoit Combemale , Judith Michael , Bernhard Rumpe , Manuel Wimmer , Andreas Wortmann

Modern organizations necessitate continuous business processes improvement to maintain efficiency, adaptability, and competitiveness. In the last few years, the Internet of Things, via the deployment of sensors and actuators, has heavily…

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

Industrial process optimization and control is crucial to increase economic and ecologic efficiency. However, data sovereignty, differing goals, or the required expert knowledge for implementation impede holistic implementation. Further,…

Machine Learning · Computer Science 2024-08-28 Johannes Emmert , Ronald Mendez , Houman Mirzaalian Dastjerdi , Christopher Syben , Andreas Maier

Human-centred systems require an understanding of human actions in the physical world. Temporally extended sequences of actions are intentional and structured, yet existing methods for recognising what actions are performed often do not…

Artificial Intelligence · Computer Science 2026-04-21 Rimvydas Rubavicius , Manisha Dubey , N. Siddharth , Subramanian Ramamoorthy

Purpose: Digital twins are virtual interactive models of the real world, exhibiting identical behavior and properties. In surgical applications, computational analysis from digital twins can be used, for example, to enhance situational…

As the real-time digital counterpart of a physical system or process, digital twins are utilized for system simulation and optimization. Neural networks are one way to build a digital twins model by using data especially when a…

Machine Learning · Computer Science 2021-12-03 Chao Sun , Victor Guang Shi

Digital twins have become popular for their ability to monitor and optimize a process or a machine, ideally through its complete life cycle using simulations and sensor data. In this paper, we focus on the challenge of accurate and…

Systems and Control · Electrical Eng. & Systems 2023-10-30 Karim Cherifi , Philipp Schulze , Volker Mehrmann , Leo Goßlau , Pascal Lünnemann

Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine…

This paper aims to provide a comprehensive critical overview on how entities and their interactions in Complex Networked Systems (CNS) are modelled across disciplines as they approach their ultimate goal of creating a Digital Twin (DT) that…

Systems and Control · Electrical Eng. & Systems 2022-02-22 Jiaqi Wen , Bogdan Gabrys , Katarzyna Musial

Engineering regulatory compliance in complex Cyber-Physical Systems (CPS), such as smart warehouse logistics, is challenging due to the open and dynamic nature of these systems, scales, and unpredictable modes of human-robot interactions…

Systems and Control · Electrical Eng. & Systems 2024-10-28 Nan Zhang , Rami Bahsoon , Nikos Tziritas , Georgios Theodoropoulos

Quantifying the uncertainty in predictive models is critical for establishing trust and enabling risk-informed decision making for personalized medicine. In contrast to one-size-fits-all approaches that seek to mitigate risk at the…

Computational Engineering, Finance, and Science · Computer Science 2025-05-15 Graham Pash , Umberto Villa , David A. Hormuth , Thomas E. Yankeelov , Karen Willcox

Digital twins are transforming engineering and applied sciences by enabling real-time monitoring, simulation, and predictive analysis of physical systems and processes. However, conventional digital twins rely primarily on passive data…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Matteo Torzoni , Domenico Maisto , Andrea Manzoni , Francesco Donnarumma , Giovanni Pezzulo , Alberto Corigliano

Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel…

Performance · Computer Science 2020-06-25 Francesco Cremonesi , Georg Hager , Gerhard Wellein , Felix Schürmann

Digital twins, as precise digital representations of physical systems, have evolved from passive simulation tools into intelligent and autonomous entities through the integration of artificial intelligence technologies. This paper presents…

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