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Effective clinical history taking is a foundational yet underexplored component of clinical reasoning. While large language models (LLMs) have shown promise on static benchmarks, they often fall short in dynamic, multi-turn diagnostic…

Computation and Language · Computer Science 2026-01-30 Yang Zhou , Zhenting Sheng , Mingrui Tan , Yuting Song , Jun Zhou , Yu Heng Kwan , Lian Leng Low , Yang Bai , Yong Liu

Background: Natural Language Processing (NLP) is widely used to extract clinical insights from Electronic Health Records (EHRs). However, the lack of annotated data, automated tools, and other challenges hinder the full utilisation of NLP…

Computation and Language · Computer Science 2023-06-23 Elias Hossain , Rajib Rana , Niall Higgins , Jeffrey Soar , Prabal Datta Barua , Anthony R. Pisani , Ph. D , Kathryn Turner}

Due to their architecture and vast pre-training data, large language models (LLMs) demonstrate strong text classification performance. However, LLM output - here, the category assigned to a text - depends heavily on the wording of the…

Computation and Language · Computer Science 2025-12-04 Kylie L. Anglin , Stephanie Milan , Brittney Hernandez , Claudia Ventura

Chain-of-Thought (CoT) prompting has been used to enhance the reasoning capability of LLMs. However, its reliability in security-sensitive analytical tasks remains insufficiently examined, particularly under structured human evaluation.…

Cryptography and Security · Computer Science 2026-04-07 Jiling Zhou , Aisvarya Adeseye , Seppo Virtanen , Antti Hakkala , Jouni Isoaho

This paper introduces an approach that combines the language reasoning capabilities of large language models (LLMs) with the benefits of local training to tackle complex, domain-specific tasks. Specifically, the authors demonstrate their…

Computation and Language · Computer Science 2023-08-04 V. K. Cody Bumgardner , Aaron Mullen , Sam Armstrong , Caylin Hickey , Jeff Talbert

Research shows that dialogue, the interactive process through which participants articulate their thinking, plays a central role in constructing shared understanding, coordinating action, and shaping learning outcomes in teams. Analysing…

Participant recruitment based on unstructured medical texts such as clinical notes and radiology reports has been a challenging yet important task for the cohort establishment in clinical research. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2023-07-24 Zihan Guan , Zihao Wu , Zhengliang Liu , Dufan Wu , Hui Ren , Quanzheng Li , Xiang Li , Ninghao Liu

Electronic health records include information on patients' status and medical history, which could cover the history of diseases and disorders that could be hereditary. One important use of family history information is in precision health,…

Computation and Language · Computer Science 2024-03-18 Xiang Dai , Sarvnaz Karimi , Nathan O'Callaghan

Despite advances in machine learning (ML) and large language models (LLMs), rule-based natural language processing (NLP) systems remain active in clinical settings due to their interpretability and operational efficiency. However, their…

Computation and Language · Computer Science 2025-06-23 Jianlin Shi , Brian T. Bucher

Electronic health records (EHRs) contain valuable patient data for health-related prediction tasks, such as disease prediction. Traditional approaches rely on supervised learning methods that require large labeled datasets, which can be…

Computation and Language · Computer Science 2024-03-26 Hejie Cui , Zhuocheng Shen , Jieyu Zhang , Hui Shao , Lianhui Qin , Joyce C. Ho , Carl Yang

Textual data from social platforms captures various aspects of mental health through discussions around and across issues, while users reach out for help and others sympathize and offer support. We propose a comprehensive framework that…

Social and Information Networks · Computer Science 2025-03-04 Vaishali Aggarwal , Sachin Thukral , Krushil Patel , Arnab Chatterjee

Longitudinal health agents must reason across multi-source trajectories that combine continuous device streams, sparse clinical exams, and episodic life events - yet evaluating them is hard: real-world data cannot be released at scale, and…

Artificial Intelligence · Computer Science 2026-04-06 Chao Li , Cailiang Liu , Ang Gao , Kexin Deng , Shu Zhang , Langping Xu , Xiaotong Shi , Xionghao Ding , Jian Pei , Xun Jiang

Stress, arising from the dynamic interaction between external stressors, individual appraisals, and physiological or psychological responses, significantly impacts health yet is often underreported and inconsistently documented, typically…

Computation and Language · Computer Science 2025-10-03 Hyeoneui Kim , Jeongha Kim , Huijing Xu , Jinsun Jung , Sunghoon Kang , Sun Joo Jang

Objective: Fluoropyrimidines are widely prescribed for colorectal and breast cancers, but are associated with toxicities such as hand-foot syndrome and cardiotoxicity. Since toxicity documentation is often embedded in clinical notes, we…

Computation and Language · Computer Science 2025-10-24 Xizhi Wu , Madeline S. Kreider , Philip E. Empey , Chenyu Li , Yanshan Wang

Annotators' sociodemographic backgrounds (i.e., the individual compositions of their gender, age, educational background, etc.) have a strong impact on their decisions when working on subjective NLP tasks, such as toxic language detection.…

Computation and Language · Computer Science 2024-02-09 Tilman Beck , Hendrik Schuff , Anne Lauscher , Iryna Gurevych

Electronic Health Records (EHRs) contain rich temporal dynamics that conventional encoding approaches fail to adequately capture. While Large Language Models (LLMs) show promise for EHR modeling, they struggle to reason about sequential…

Artificial Intelligence · Computer Science 2025-10-01 Zekai Chen , Arda Pekis , Kevin Brown

Timing of clinical events is central to characterization of patient trajectories, enabling analyses such as process tracing, forecasting, and causal reasoning. However, structured electronic health records capture few data elements critical…

Computation and Language · Computer Science 2025-04-18 Jing Wang , Jeremy C Weiss

Understanding the longitudinally changing associations between Social Determinants of Health (SDOH) and stroke mortality is essential for effective stroke management. Previous studies have uncovered significant regional disparities in the…

Methodology · Statistics 2025-02-04 Fangzhi Luo , Jianbin Tan , Donglan Zhang , Hui Huang , Ye Shen

Background: Social support (SS) and social isolation (SI) are social determinants of health (SDOH) associated with psychiatric outcomes. In electronic health records (EHRs), individual-level SS/SI is typically documented as narrative…

OpenNotes enables patients to access EHR notes, but medical jargon can hinder comprehension. To improve understanding, we evaluated closed- and open-source LLMs for extracting and prioritizing key medical terms using prompting, fine-tuning,…

Computation and Language · Computer Science 2026-05-08 Won Seok Jang , Sharmin Sultana , Zonghai Yao , Hieu Tran , Zhichao Yang , Sunjae Kwon , Hong Yu