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Accurate prediction of protein active-site structures remains a central challenge in structural biology, particularly for short and flexible peptide fragments where conventional and simulation-based methods often fail. Here, we present a…

Lattice protein folding models are a cornerstone of computational biophysics. Although these models are a coarse grained representation, they provide useful insight into the energy landscape of natural proteins. Finding low-energy…

Determining the ground state of a many-body Hamiltonian is a central problem across physics, chemistry, and combinatorial optimization, yet it is often classically intractable due to the exponential growth of Hilbert space with system size.…

Quantum Physics · Physics 2026-02-24 Jungyun Lee , Daniel K. Park

Models of interacting many-body quantum systems that may realize new exotic phases of matter, notably quantum spin liquids, are challenging to study using even state-of-the-art classical methods such as tensor network simulations. Quantum…

Quantum Physics · Physics 2025-04-16 Aaron Szasz , Ed Younis , Wibe Albert de Jong

We aim to explore a more efficient way to simulate few-body dynamics on quantum computers. Instead of mapping the second quantization of the system Hamiltonian to qubit Pauli gates representation via the Jordan-Wigner transform, we propose…

Quantum Physics · Physics 2025-09-09 Peng Guo , Jaime Park , Frank X. Lee

Computing the vacuum and energy spectrum in non-Abelian, interacting lattice gauge theories remains an open challenge, in part because approximating the continuum limit requires large lattices and huge Hilbert spaces. To address this…

This study introduces a novel framework that brings together two main Quantum Programming methodologies, gate-based Quantum Computing and Quantum Annealing, by applying the Model-Driven Engineering principles. This aims to enhance the…

Quantum Physics · Physics 2024-10-14 Furkan Polat , Hasan Tuncer , Armin Moin , Moharram Challenger

In this paper we consider a model of quantum computation based on n atoms of laser-cooled and trapped linearly in a cavity and realize it as the n atoms Tavis-Cummings Hamiltonian interacting with n external (laser) fields. We solve the…

Quantum Physics · Physics 2009-11-10 Kazuyuki Fujii , Kyoko Higashida , Ryosuke Kato , Yukako Wada

{Many-body quantum states at thermal equilibrium are ubiquitous in nature. Investigating their dynamical properties is a formidable task due to the complexity of the Hilbert space they live in. Quantum computers may have the potential to…

Quantum Physics · Physics 2024-07-25 Mirko Consiglio , Tony J. G. Apollaro

Quantum many-body systems exhibit an extremely diverse range of phases and physical phenomena. Here, we prove that the entire physics of any other quantum many-body system is replicated in certain simple, "universal" spin-lattice models. We…

Quantum Physics · Physics 2019-10-07 Toby Cubitt , Ashley Montanaro , Stephen Piddock

We present the first results of a quantum field approach to nuclear models obtained by lattice techniques. Renormalization effects for fermion mass and coupling constant in case of scalar and pseudoscalar interaction lagrangian densities…

High Energy Physics - Lattice · Physics 2010-03-19 F. De Soto , J. Carbonell , C. Roiesnel , Ph. Boucaud , J. P. Leroy , O. Pene

Weakly bound states often occur in nuclear physics. To precisely understand their properties, the coupling to the continuum should be worked out explicitely. In a first step, we use a simple nuclear model in the continuum and on a lattice…

Nuclear Theory · Physics 2020-12-21 J. -J. Wu , Ulf-G. Meißner

Strongly interacting quantum many-body systems are fundamentally compelling and ubiquitous in science. However, their complexity generally prevents exact solutions of their dynamics. Precisely engineered ultracold atomic gases are emerging…

Atomic Physics · Physics 2015-06-12 M. J. Martin , M. Bishof , M. D. Swallows , X. Zhang , C. Benko , J. von-Stecher , A. V. Gorshkov , A. M. Rey , Jun Ye

We show how nuclear effective field theory (EFT) and ab initio nuclear-structure methods can turn input from lattice quantum chromodynamics (LQCD) into predictions for the properties of nuclei. We argue that pionless EFT is the appropriate…

Nuclear Theory · Physics 2015-03-05 N. Barnea , L. Contessi , D. Gazit , F. Pederiva , U. van Kolck

The separation between physics at low and high energies is essential for physics to have any utility; the details of quantum gravity are not necessary to calculate the trajectory of a cannon ball. However, physics at low and high energies…

Quantum Physics · Physics 2024-09-06 Roland C. Farrell

Quantum simulation of fermionic systems is a promising application of quantum computers, but in order to program them, we need to map fermionic states and operators to qubit states and quantum gates. While quantum processors may be built as…

Quantum Physics · Physics 2019-08-05 Mark Steudtner , Stephanie Wehner

While quantum computers are capable of simulating many quantum systems efficiently, the simulation algorithms must begin with the preparation of an appropriate initial state. We present a method for generating physically relevant quantum…

Quantum Physics · Physics 2009-05-29 Nicholas J. Ward , Ivan Kassal , Alán Aspuru-Guzik

A brief excursion into the three-body problem in quantum mechanics is presented for graduate students or researchers in nuclear physics. Starting from single-particle coordinates, the three-body Schr\"{o}dinger equation is systematically…

Nuclear Theory · Physics 2026-02-17 Emile Meoto

Geometric model fitting is a challenging but fundamental computer vision problem. Recently, quantum optimization has been shown to enhance robust fitting for the case of a single model, while leaving the question of multi-model fitting…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Matteo Farina , Luca Magri , Willi Menapace , Elisa Ricci , Vladislav Golyanik , Federica Arrigoni

Exploring nuclear physics through the fundamental constituents of the strong force -- quarks and gluons -- is a formidable challenge. While numerical calculations using lattice quantum chromodynamics offer the most promising approach for…

High Energy Physics - Lattice · Physics 2024-12-19 Debsubhra Chakraborty , Piyush Srivastava , Arpith Kumar , Nilmani Mathur