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The computational demands of modern AI have spurred interest in optical neural networks (ONNs) which offer the potential benefits of increased speed and lower power consumption. However, current ONNs face various challenges,most…

Neural and Evolutionary Computing · Computer Science 2024-01-29 Xiansong Meng , Deming Kong , Kwangwoong Kim , Qiuchi Li , Po Dong , Ingemar J. Cox , Christina Lioma , Hao Hu

Most modern computing tasks have digital electronic input and output data. Due to these constraints imposed by real-world use cases of computer systems, any analog computing accelerator, whether analog electronic or optical, must perform an…

Hardware Architecture · Computer Science 2024-01-02 James T. Meech , Vasileios Tsoutsouras , Phillip Stanley-Marbell

Analog electronic and optical computing exhibit tremendous advantages over digital computing for accelerating deep learning when operations are executed at low precision. In this work, we derive a relationship between analog precision,…

Machine Learning · Computer Science 2021-02-15 Sahaj Garg , Joe Lou , Anirudh Jain , Mitchell Nahmias

Prevalent Computational Aberration Correction (CAC) methods are typically tailored to specific optical systems, leading to poor generalization and labor-intensive re-training for new lenses. Developing CAC paradigms capable of generalizing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Xiaolong Qian , Qi Jiang , Yao Gao , Lei Sun , Zhonghua Yi , Kailun Yang , Luc Van Gool , Kaiwei Wang

Background: Despite high in-silico performance (AUC >0.80), 85% of AI cancer biomarkers fail clinical translation, exposing a critical algorithm-to-outcome gap. Methods: We introduce the Algorithm-to-Outcome Concordance (AOC) framework,…

Quantitative Methods · Quantitative Biology 2026-01-06 Xiyao Yu , Kai Fu

We propose a new signaling scheme for on-chip optical-electrical-optical artificial neural networks that utilizes orthogonal delay-division multiplexing and pilot-tone based self-homodyne detection. This scheme offers a more efficient…

Emerging Technologies · Computer Science 2023-10-20 Andrea Zazzi , Arka Dipta Das , Lukas Hüssen , Renato Negra , Jeremy Witzens

Mixed-signal artificial neural networks (ANNs) that employ analog matrix-multiplication accelerators can achieve higher speed and improved power efficiency. Though analog computing is known to be susceptible to noise and device…

Signal Processing · Electrical Eng. & Systems 2021-07-01 Joseph Ulseth , Zheyuan Zhu , Guifang Li , Shuo Pang

This paper describes the design, implementation, and evaluation of Otak, a system that allows two non-colluding cloud providers to run machine learning (ML) inference without knowing the inputs to inference. Prior work for this problem…

Cryptography and Security · Computer Science 2020-09-14 Muqsit Nawaz , Aditya Gulati , Kunlong Liu , Vishwajeet Agrawal , Prabhanjan Ananth , Trinabh Gupta

Analog design often slows down because even small changes to device sizes or biases require expensive simulation cycles, and high-quality solutions typically occupy only a narrow part of a very large search space. While existing optimizers…

Machine Learning · Computer Science 2026-03-27 Sounak Dutta , Fin Amin , Sushil Panda , Jonathan Rabe , Yuejiang Wen , Paul Franzon

Analog in-memory computing (AIMC) is a promising compute paradigm to improve speed and power efficiency of neural network inference beyond the limits of conventional von Neumann-based architectures. However, AIMC introduces fundamental…

LIT-PCBA is widely used to benchmark virtual screening models, but our audit reveals that it is fundamentally compromised. We find extensive data leakage and molecular redundancy across its splits, including 2D-identical ligands within and…

Machine Learning · Computer Science 2025-08-08 Amber Huang , Ian Scott Knight , Slava Naprienko

Mixed-signal hardware accelerators for deep learning achieve orders of magnitude better power efficiency than their digital counterparts. In the ultra-low power consumption regime, limited signal precision inherent to analog computation…

Emerging Technologies · Computer Science 2019-04-04 Michael Klachko , Mohammad Reza Mahmoodi , Dmitri B. Strukov

Analog feature extraction is a power-efficient and re-emerging signal processing paradigm for implementing the front-end feature extractor in on device keyword-spotting systems. Despite its power efficiency and re-emergence, there is little…

Audio and Speech Processing · Electrical Eng. & Systems 2023-04-19 Subhajit Ray , Xinghua Sun , Nolan Tremelling , Maria Gordiyenko , Peter Kinget

Objective quality assessment of digital holograms has proven to be a challenging task. While prediction of perceptual quality of the recorded 3D content from the holographic wavefield is an open problem; perceptual quality assessment from…

Image and Video Processing · Electrical Eng. & Systems 2020-10-23 Ayyoub Ahar , Tobias Birnbaum , Maksymilian Chlipala , Weronika Zaperty , Saeed Mahmoudpour , Tomasz Kozacki , Malgorzata Kujawinska , Peter Schelkens

Chromatic dispersion is a common problem to degrade the system resolution in optical coherence tomography (OCT). This study is to develop a deep learning network for automated dispersion compensation (ADC-Net) in OCT. The ADC-Net is based…

Purpose: To evaluate Pegasus-OCT, a clinical decision support software for the identification of features of retinal disease from macula OCT scans, across heterogenous populations involving varying patient demographics, device…

Image and Video Processing · Electrical Eng. & Systems 2019-07-12 Kanwal K. Bhatia , Mark S. Graham , Louise Terry , Ashley Wood , Paris Tranos , Sameer Trikha , Nicolas Jaccard

The growing demand for edge computing and AI drives research into analog in-memory computing using memristors, which overcome data movement bottlenecks by computing directly within memory. However, device failures and variations critically…

Emerging Technologies · Computer Science 2025-07-16 Zhicheng Xu , Jiawei Liu , Sitao Huang , Zefan Li , Shengbo Wang , Bo Wen , Ruibin Mao , Mingrui Jiang , Giacomo Pedretti , Jim Ignowski , Kaibin Huang , Can Li

This work investigates the role of the emerging Analog In-memory computing (AIMC) paradigm in enabling Medical AI analysis and improving the certainty of these models at the edge. It contrasts AIMC's efficiency with traditional digital…

Image and Video Processing · Electrical Eng. & Systems 2024-03-15 Imane Hamzaoui , Hadjer Benmeziane , Zayneb Cherif , Kaoutar El Maghraoui

The joint design of the optical system and the downstream algorithm is a challenging and promising task. Due to the demand for balancing the global optimal of imaging systems and the computational cost of physical simulation, existing…

Many SOCs today contain both digital and analog embedded cores. Even though the test cost for such mixed-signal SOCs is significantly higher than that for digital SOCs, most prior research in this area has focused exclusively on digital…

Hardware Architecture · Computer Science 2011-11-09 Anuja Sehgal , Fang Liu , Sule Ozev , Krishnendu Chakrabarty
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