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The emergence of foundation models in neuroimaging is driven by the increasing availability of large-scale and heterogeneous brain imaging datasets. Recent advances in self-supervised learning, particularly reconstruction-based objectives,…

Machine Learning · Computer Science 2025-11-04 Ruthwik Reddy Doodipala , Pankaj Pandey , Carolina Torres Rojas , Manob Jyoti Saikia , Ranganatha Sitaram

With the growing interest in foundation models for brain signals, graph-based pretraining has emerged as a promising paradigm for learning transferable representations from connectome data. However, existing contrastive and masked…

Machine Learning · Computer Science 2026-03-10 Xinxu Wei , Rong Zhou , Lifang He , Yu Zhang

Deep MRI reconstruction is commonly performed with conditional models that de-alias undersampled acquisitions to recover images consistent with fully-sampled data. Since conditional models are trained with knowledge of the imaging operator,…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Alper Güngör , Salman UH Dar , Şaban Öztürk , Yilmaz Korkmaz , Gokberk Elmas , Muzaffer Özbey , Tolga Çukur

Functional MRI (fMRI) is crucial for studying brain function and diagnosing neurological disorders. However, existing analysis methods suffer from reproducibility and transferability challenges due to complex preprocessing pipelines and…

Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data. Here we show that a single self-supervised representation can…

Machine Learning · Computer Science 2026-05-27 Yizhou Wu , Shansong Wang , Yuheng Li , Mojtaba Safari , Mingzhe Hu , Chih-Wei Chang , Harini Veeraraghavan , Xiaofeng Yang

Recent advances in deep learning have shown that learning robust feature representations is critical for the success of many computer vision tasks, including medical image segmentation. In particular, both transformer and…

Computer Vision and Pattern Recognition · Computer Science 2025-02-03 David Li , Anvar Kurmukov , Mikhail Goncharov , Roman Sokolov , Mikhail Belyaev

Alzheimer's disease (AD) progresses heterogeneously across individuals, motivating subject-specific synthesis of follow-up magnetic resonance imaging (MRI) to support progression assessment. While Diffusion Transformers (DiT), an emerging…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Juneyong Lee , Geonwoo Baek , Ikbeom Jang

Foundation models, particularly Large Language Models (LLMs), have revolutionized text and video processing, yet time series data presents distinct challenges for such approaches due to domain-specific features such as missing values,…

Machine Learning · Computer Science 2025-02-12 Defu Cao , Wen Ye , Yizhou Zhang , Yan Liu

The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Samuel W. Remedios , Aaron Carass , Jerry L. Prince , Blake E. Dewey

Brain network analysis has emerged as pivotal method for gaining a deeper understanding of brain functions and disease mechanisms. Despite the existence of various network construction approaches, shortcomings persist in the learning of…

Computer Vision and Pattern Recognition · Computer Science 2023-11-10 Yongcheng Zong , Shuqiang Wang

Structural magnetic resonance imaging (sMRI) provides accurate estimates of the brain's structural organization and learning invariant brain representations from sMRI is an enduring issue in neuroscience. Previous deep representation…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Ning Jiang , Gongshu Wang , Tianyi Yan

Reconstructing images seen by people from their fMRI brain recordings provides a non-invasive window into the human brain. Despite recent progress enabled by diffusion models, current methods often lack faithfulness to the actual seen…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Roman Beliy , Amit Zalcher , Jonathan Kogman , Navve Wasserman , Michal Irani

The development of foundation models for brain MRI depends critically on the scale, diversity, and consistency of available data, yet systematic assessments of these factors remain scarce. In this study, we analyze 54 publicly accessible…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Minh Sao Khue Luu , Margaret V. Benedichuk , Ekaterina I. Roppert , Roman M. Kenzhin , Bair N. Tuchinov

Multimodal learning, especially large-scale multimodal pre-training, has developed rapidly over the past few years and led to the greatest advances in artificial intelligence (AI). Despite its effectiveness, understanding the underlying…

Neural and Evolutionary Computing · Computer Science 2022-08-18 Haoyu Lu , Qiongyi Zhou , Nanyi Fei , Zhiwu Lu , Mingyu Ding , Jingyuan Wen , Changde Du , Xin Zhao , Hao Sun , Huiguang He , Ji-Rong Wen

Retinal foundation models have significantly advanced retinal image analysis by leveraging self-supervised learning to reduce dependence on labeled data while achieving strong generalization. Many recent approaches enhance retinal image…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Yeonkyung Lee , Woojung Han , Youngjun Jun , Hyeonmin Kim , Jungkyung Cho , Seong Jae Hwang

Deep learning analyses have offered sensitivity leaps in detection of cognitive states from functional MRI (fMRI) measurements across the brain. Yet, as deep models perform hierarchical nonlinear transformations on their input, interpreting…

Signal Processing · Electrical Eng. & Systems 2023-07-20 Hasan Atakan Bedel , Tolga Çukur

Recent fMRI-to-image approaches mainly focused on associating fMRI signals with specific conditions of pre-trained diffusion models. These approaches, while producing high-quality images, capture only a limited aspect of the complex…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Jingyang Huo , Yikai Wang , Xuelin Qian , Yun Wang , Chong Li , Jianfeng Feng , Yanwei Fu

This paper presents the Large Vision Diffusion Transformer (LaVin-DiT), a scalable and unified foundation model designed to tackle over 20 computer vision tasks in a generative framework. Unlike existing large vision models directly adapted…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Zhaoqing Wang , Xiaobo Xia , Runnan Chen , Dongdong Yu , Changhu Wang , Mingming Gong , Tongliang Liu

Brain foundation models have achieved remarkable advances across a wide range of neuroscience tasks. However, most existing models are limited to a single functional modality, restricting their ability to exploit complementary…

Machine Learning · Computer Science 2026-05-18 Hanning Guo , Hanwen Bi , Farah Abdellatif , Andrei Galbenus , Jon. N. Shah , Abigail Morrison , Jürgen Dammers

Diffusion MRI is a non-invasive, in-vivo biomedical imaging method for mapping tissue microstructure. Applications include structural connectivity imaging of the human brain and detecting microstructural neural changes. However, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Amir Sadikov , Xinlei Pan , Hannah Choi , Lanya T. Cai , Pratik Mukherjee
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