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Large Language Models (LLMs) are increasingly adopted as conversational assistants in genomics, where they are mainly used to reason over biological knowledge, annotations, and analysis outputs through natural language interfaces. However,…

Genomics · Quantitative Biology 2026-04-08 Weicai Long , Yusen Hou , Junning Feng , Houcheng Su , Shuo Yang , Donglin Xie , Yanlin Zhang

The ability of Large Language Models (LLMs) to generate structured outputs that follow arbitrary schemas is crucial to a wide range of downstream tasks that require diverse structured representations of results such as information…

Computation and Language · Computer Science 2025-11-25 James Y. Huang , Wenxuan Zhou , Nan Xu , Fei Wang , Qin Liu , Sheng Zhang , Hoifung Poon , Muhao Chen

Large language models (LLMs) have shown remarkable emergent capabilities, transforming the execution of functional tasks by leveraging external tools for complex problems that require specialized processing or up-to-date data. While…

Computation and Language · Computer Science 2025-08-22 Wenjun Li , Dexun Li , Kuicai Dong , Cong Zhang , Hao Zhang , Weiwen Liu , Yasheng Wang , Ruiming Tang , Yong Liu

We present a novel benchmark designed to rigorously evaluate the capabilities of large language models (LLMs) in mathematical reasoning and algorithmic code synthesis tasks. The benchmark comprises integer sequence generation tasks sourced…

Machine Learning · Computer Science 2025-11-11 Daniel O'Malley , Manish Bhattarai , Nishath Rajiv Ranasinghe , Erick Draayer , Javier Santos

Augmenting large language models (LLM) to use external tools enhances their performance across a variety of tasks. However, prior works over-rely on task-specific demonstration of tool use that limits their generalizability and…

Artificial Intelligence · Computer Science 2024-02-01 Yining Lu , Haoping Yu , Daniel Khashabi

The rise of Internet of Things (IoT) devices in the physical world necessitates voice-based interfaces capable of handling complex user experiences. While modern Large Language Models (LLMs) already demonstrate strong tool-usage…

Computation and Language · Computer Science 2026-05-11 Maximillian Chen , Xuanming Zhang , Michael Peng , Zhou Yu , Alexandros Papangelis , Yohan Jo

Large language models (LLMs) have displayed massive improvements in reasoning and decision-making skills and can hold natural conversations with users. Many recent works seek to augment LLM-based assistants with external tools so they can…

Computation and Language · Computer Science 2023-11-21 Nicholas Farn , Richard Shin

In precision medicine, quantitative multi-omic features, topological context, and textual biological knowledge play vital roles in identifying disease-critical signaling pathways and targets. Existing pipelines capture only part of…

Artificial Intelligence · Computer Science 2025-12-17 Heming Zhang , Di Huang , Wenyu Li , Michael Province , Yixin Chen , Philip Payne , Fuhai Li

Large Language Models have been increasingly employed in the creation of Virtual Assistants due to their ability to generate human-like text and handle complex inquiries. While these models hold great promise, challenges such as…

Computation and Language · Computer Science 2026-04-30 Dumitru Verşebeniuc , Martijn Elands , Sara Falahatkar , Chiara Magrone , Mohammad Falah , Martijn Boussé , Aki Härmä

Large language model (LLM) agents are increasingly used for complex tasks, yet deployed agents often remain static, failing to adapt as user needs evolve. This creates a tension between the need for continuous service and the necessity of…

Machine Learning · Computer Science 2026-03-19 Peng Xia , Jianwen Chen , Xinyu Yang , Haoqin Tu , Jiaqi Liu , Kaiwen Xiong , Siwei Han , Shi Qiu , Haonian Ji , Yuyin Zhou , Zeyu Zheng , Cihang Xie , Huaxiu Yao

Retrieval-augmented large language models (R-LLMs) combine pre-trained large language models (LLMs) with information retrieval systems to improve the accuracy of factual question-answering. However, current libraries for building R-LLMs…

Computation and Language · Computer Science 2023-10-17 Yasuto Hoshi , Daisuke Miyashita , Youyang Ng , Kento Tatsuno , Yasuhiro Morioka , Osamu Torii , Jun Deguchi

This project successfully developed, evaluated and integrated a Voice User Interface (VUI) into a web application that we are developing for immersive molecular graphics. Said app provides augmented and virtual reality (AR and VR)…

Human-Computer Interaction · Computer Science 2026-03-04 Fabio Cortes Rodriguez , Luciano Abriata

Clinical decision support systems require models that are not only highly accurate but also equitable and sensitive to the implications of missed diagnoses. In this study, we introduce a knowledge-guided in-context learning (ICL) framework…

Machine Learning · Computer Science 2025-07-28 Fatemeh Nazary , Yashar Deldjoo , Tommaso Di Noia , Eugenio di Sciascio

Logical reasoning is a critical benchmark for evaluating the capabilities of large language models (LLMs), as it reflects their ability to derive valid conclusions from given premises. While the combination of test-time scaling with…

Computation and Language · Computer Science 2025-08-28 Ramya Keerthy Thatikonda , Wray Buntine , Ehsan Shareghi

Large Language Models (LLMs) have the unique capability to understand and generate human-like text from input queries. When fine-tuned, these models show enhanced performance on domain-specific queries. OpenAI highlights the process of…

Computation and Language · Computer Science 2024-07-02 Scott Barnett , Zac Brannelly , Stefanus Kurniawan , Sheng Wong

The emergence of large language models (LLMs) has revolutionized natural language processing tasks. However, existing instruction-tuning datasets suffer from occupational bias: the majority of data relates to only a few occupations, which…

Computation and Language · Computer Science 2023-10-26 Mingfeng Xue , Dayiheng Liu , Kexin Yang , Guanting Dong , Wenqiang Lei , Zheng Yuan , Chang Zhou , Jingren Zhou

Large Language Models (LLMs) show potential for medical applications but often lack specialized clinical knowledge. Retrieval Augmented Generation (RAG) allows customization with domain-specific information, making it suitable for…

The clinical utility of deep learning models for medical image segmentation is severely constrained by their inability to generalize to unseen domains. This failure is often rooted in the models learning spurious correlations between…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Tao Tang , Shijie Xu , Jionglong Su , Zhixiang Lu

Reinforcement Learning (RL) has shown great potential for autonomous decision-making in the cybersecurity domain, enabling agents to learn through direct environment interaction. However, RL agents in Autonomous Cyber Operations (ACO)…

Cryptography and Security · Computer Science 2026-02-17 Konur Tholl , François Rivest , Mariam El Mezouar , Adrian Taylor , Ranwa Al Mallah

Large Language Models (LLMs) are widely used to support software developers in tasks such as code generation, optimization, and documentation. However, their ability to improve existing programming answers in a human-like manner remains…

Software Engineering · Computer Science 2026-01-27 Suborno Deb Bappon , Saikat Mondal , Chanchal K. Roy , Kevin Schneider