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The selection of research topics by scientists can be viewed as an exploration process conducted by individuals with cognitive limitations traversing a complex cognitive landscape influenced by both individual and social factors. While…

Physics and Society · Physics 2023-12-14 Feifan Liu , Shuang Zhang , Haoxiang Xia

A fundamental question in the conjunction of information theory, biophysics, bioinformatics and thermodynamics relates to the principles and processes that guide the development of natural intelligence in natural environments where…

Neural and Evolutionary Computing · Computer Science 2024-12-31 Serge Dolgikh

Limited resources motivate decomposing large-scale problems into smaller,``local" subsystems and stitching together the so-found solutions. We explore the physics underlying this approach and discuss the concept of ``local hardness", i.e.,…

Disordered Systems and Neural Networks · Physics 2025-12-24 Mutian Shen , Gerardo Ortiz , Zhiqiao Dong , Martin Weigel , Zohar Nussinov

While fields like Artificial Life have made huge strides in quantifying the mechanisms that distinguish living systems from non-living ones, particular mechanisms remain difficult to reproduce in silico. Known as open-endedness, we've been…

Biological Physics · Physics 2024-07-18 Alyssa M Adams , Eliott Jacopin , Praful Gagrani , Olaf Witkowski

To demarcate the limits of experimental knowledge we probe the limits of what might be called an experiment. By appeal to examples of scientific practice from astrophysics and analogue gravity, we demonstrate that the reliability of…

History and Philosophy of Physics · Physics 2021-03-03 Peter W. Evans , Karim P. Y. Thébault

In this paper, we relate the philosophical literature on pessimism traps to information cascades, a formal model derived from the economics and mathematics literature. A pessimism trap is a social pattern in which individuals in a…

Social and Information Networks · Computer Science 2025-04-24 Avrim Blum , Emily Diana , Kavya Ravichandran , Alexander Williams Tolbert

Infrastructure shapes societies and scientific discovery. Traditional scientific infrastructure, often static and fragmented, leads to issues like data silos, lack of interoperability and reproducibility, and unsustainable short-lived…

Neurons and Cognition · Quantitative Biology 2025-08-15 Satrajit S. Ghosh

It is well known that conservative mechanical systems exhibit local oscillatory behaviours due to their elastic and gravitational potentials, which completely characterise these periodic motions together with the inertial properties of the…

Optimization and Control · Mathematics 2023-06-26 Yannik Wotte , Sven Dummer , Nicolò Botteghi , Christoph Brune , Stefano Stramigioli , Federico Califano

Deploying reinforcement learning in safety critical domains, from autonomous vehicles to medical decision support, is constrained by failures arising when systems encounter unfamiliar conditions. We argue that the fundamental bottleneck is…

Systems and Control · Electrical Eng. & Systems 2026-05-27 Chayan Banerjee , Ethan Goan

In the quest to align deep learning with the sciences to address calls for rigor, safety, and interpretability in machine learning systems, this contribution identifies key missing pieces: the stages of hypothesis formulation and testing,…

Machine Learning · Computer Science 2019-04-25 Jessica Zosa Forde , Michela Paganini

The most pressing problems in science are neither empirical nor theoretical, but infrastructural. Scientific practice is defined by coproductive, mutually reinforcing infrastructural deficits and incentive systems that everywhere constrain…

General Literature · Computer Science 2022-09-16 Jonny L. Saunders

Anticipating the low energy arrangements of atoms in space is an indispensable scientific task. Modern stochastic approaches to searching for these configurations depend on the optimisation of structures to nearby local minima in the energy…

Materials Science · Physics 2019-02-07 Chris J. Pickard

Information theory has explained the organization of many biological phenomena, from the physiology of sensory receptive fields to the variability of certain DNA sequence ensembles. Some scholars have proposed that information should…

Other Quantitative Biology · Quantitative Biology 2010-10-25 Edward K. Agarwala , Hillel J. Chiel , Peter J. Thomas

Information gathered along a path is inherently submodular; the incremental amount of information gained along a path decreases due to redundant observations. In addition to submodularity, the incremental amount of information gained is a…

Robotics · Computer Science 2020-10-28 William Clark , Maani Ghaffari

Artificial intelligence has demonstrated remarkable capability in predicting scientific properties, yet scientific discovery remains an inherently physical, long-horizon pursuit governed by experimental cycles. Most current computational…

Artificial Intelligence · Computer Science 2026-03-23 Xiang Zhuang , Chenyi Zhou , Kehua Feng , Zhihui Zhu , Yunfan Gao , Yijie Zhong , Yichi Zhang , Junjie Huang , Keyan Ding , Lei Bai , Haofen Wang , Qiang Zhang , Huajun Chen

While frameworks based on physical grounds (like the Drift-Diffusion Model) have been exhaustively used in psychology and neuroscience to describe perceptual decision-making in humans, analogous approaches for more complex situations like…

Physics and Society · Physics 2022-12-19 Javier Cristín , Vicenç Méndez , Daniel Campos

The rapid evolution of artificial intelligence has led to expectations of transformative impact on science, yet current systems remain fundamentally limited in enabling genuine scientific discovery. This perspective contends that progress…

Artificial Intelligence · Computer Science 2025-12-16 Karthik Duraisamy

The success of quantum optimal control for both experimental and theoretical objectives is connected to the topology of the corresponding control landscapes, which are free from local traps if three conditions are met: (1) the quantum…

Situational awareness, the capacity of an AI system to recognize its own nature, understand its training and deployment context, and reason strategically about its circumstances, is widely considered among the most dangerous emergent…

Artificial Intelligence · Computer Science 2026-03-11 Subramanyam Sahoo , Aman Chadha , Vinija Jain , Divya Chaudhary

Scientific discovery is constrained not only by what is true, but by what is cognitively available to the researchers currently exploring a field. Many directions are coherent in light of the literature yet unlikely to be proposed because…

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