Related papers: Bicuspid Valve Closure and Backflow Prevention: Ro…

Heart disease is one of leading causes of mortality worldwide. Healthy heart valves are key for proper heart function. When these valves dysfunction, a replacement is often necessary in severe cases. The current study presents an…

Mechanical heart valve replacement is the preferred alternative in younger patients with severe symptomatic aortic valve disease. However, thrombus and pannus formations are common complications associated with bileaflet mechanical heart…

Bileaflet mechanical heart valves have one of the most successful valve designs for more than 30 years. These valves are often used for aortic valve replacement, where the geometry of the aortic root sinuses may vary due to valvular disease…

There are more than 300,000 heart valves implanted annually worldwide with about 50% of them being mechanical valves. The heart valve replacement is often a common treatment for severe valvular disease. However, valves may dysfunction…

Bicuspid aortic valve is the most common congenital heart defect, affecting 1-2% of the global population. Patients with bicuspid valves frequently develop dilation and aneurysms of the ascending aorta. Both hemodynamic and genetic factors…

In Nature, liquids often circulate in channels textured with leaflets, cilia or porous walls that deform with the flow. These soft structures are optimized to passively control flows and inspire the design of novel microfluidic and soft…

The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…

We introduce an innovative lumped-parameter model of the aortic valve, designed to efficiently simulate the impact of valve dynamics on blood flow. Our reduced model includes the elastic effects associated with the leaflets' curvature and…

Immersed nonlinear elements are prevalent in biological systems that require a preferential flow direction, such as the venous and the lymphatic system. We investigate here a certain class of models where the fluid is driven by peristaltic…

Viscous flows within an elastic structure apply stress on the solid-liquid interface. The stress-field created by the viscous flow can be utilized to counter stress created by external forces and thus may be applied as a tool for delaying…

Pulsatile flow through compressed or defective blood vessels is a topic of fundamental importance in hemodynamics, particularly in cardiovascular research. This study examines flow dynamics within a tube with a bipolar cross section,…

Objective: Severe congenital aortic valve pathology in the growing patient remains a challenging clinical scenario. Bicuspidization of the diseased aortic valve has proven to be a promising repair technique with acceptable durability.…

In disordered porous media, two-phase flow of immiscible fluids (biphasic flow) is organized in patterns that sometimes exhibit fractal geometries over a range of length scales, depending on the capillary, gravitational and viscous forces…

We investigated the two-dimensional flows of a viscoplastic fluid in symmetric channels with impermeable walls under no-slip boundary conditions. As response functions for the Cauchy stress tensor of the viscoplastic fluid, we considered…

This paper presents a new method for modeling the mechanics of the aortic valve, and simulates its interaction with blood. As much as possible, the model construction is based on first principles, but such that the model is consistent with…

The invasive measurement of the hepatic venous pressure gradient is still considered as the reference method to assess the severity of portal hypertension. Even though previous studies have shown that the liver stiffness measured by…

Advances in three-dimensional imaging provide the ability to construct and analyze finite element (FE) models to evaluate the biomechanical behavior and function of atrioventricular valves. However, while obtaining patient-specific valve…

Atrial fibrillation (AF) consequences on the heart valve dynamics are usually studied along with a valvular disfunction or disease, since in medical monitoring the two pathologies are often concomitant. Aim of the present work is to study,…

The blowdown of high pressure gas in a pressure vessel produces rapid adiabatic cooling of the gas remaining in the vessel. The gas near the wall is warmed by conduction from the wall, producing radial temperature and density gradients that…

Small fluid leaks are common and frequently troublesome. We often consider how to stop a leak, but here we ask a different question: how might a leak stop itself? We experimentally study leaking flow transitions from continuous drainage to…