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Critical sized bone defects remain a major clinical challenge, requiring scaffolds that combine mechanical stability with regenerative capacity. Functionally graded (FG) scaffolds, inspired by the graded architecture of native bone, offer a…

Computational Physics · Physics 2025-11-04 Ali Entezari , Vahid Badali , Sara Checa

Correctly capturing intraoperative brain shift in image-guided neurosurgical procedures is a critical task for aligning preoperative data with intraoperative geometry for ensuring accurate surgical navigation. While the finite element…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yasmin Salehi , Dennis Giannacopoulos

Graph neural networks (GNNs) naturally align with sparse operators and unstructured discretizations, making them a promising paradigm for physics-informed machine learning in computational mechanics. Motivated by discrete physics losses and…

Machine Learning · Computer Science 2026-02-10 Jianchuan Yang , Xi Chen , Jidong Zhao

Bone serves as a remarkable example of nature's architectured material with its unique blend of strength and toughness, all at a lightweight design. Given the hierarchical nature of these materials, it is essential to understand the…

Computational stress analysis is an important step in the design of material systems. Finite element method (FEM) is a standard approach of performing stress analysis of complex material systems. A way to accelerate stress analysis is to…

Materials Science · Physics 2023-01-02 Anindya Bhaduri , Ashwini Gupta , Lori Graham-Brady

Topologically interlocking architectures can generate tough ceramics with attractive thermo-mechanical properties. This concept can make the material design pathway a challenging task, since modeling the whole design space is neither…

Computational Engineering, Finance, and Science · Computer Science 2023-05-22 Elham Kiyani , Hamidreza Yazdani Sarvestani , Hossein Ravanbakhsh , Razyeh Behbahani , Behnam Ashrafi , Meysam Rahmat , Mikko Karttunen

Achieving an optimal biomechanical environment within bone scaffolds is critical for promoting tissue regeneration, particularly in load-bearing anatomical sites where rigid fixation can induce stress shielding and compromise healing.…

The local geometrical randomness of metal foams brings complexities to the performance prediction of porous structures. Although the relative density is commonly deemed as the key factor, the stochasticity of internal cell sizes and shapes…

Machine Learning · Computer Science 2022-11-04 Da Chen , Nima Emami , Shahed Rezaei , Philipp L. Rosendahl , Bai-Xiang Xu , Jens Schneider , Kang Gao , Jie Yang

Accurately simulating soft tissue deformation is crucial for surgical training, pre-operative planning, and real-time haptic feedback systems. While physics-based models such as the finite element method (FEM) provide high-fidelity results,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-23 Madina Kojanazarova , Sidaty El Hadramy , Jack Wilkie , Georg Rauter , Philippe C. Cattin

Bone is a stiff and though, hierarchical and continuously evolving material that optimizes its structure to respond to mechanical stimuli, which also govern growth and remodeling processes. However, a full understanding of the underlying…

Applied Physics · Physics 2022-06-30 M. Fraldi , A. Cutolo , A. R. Carotenuto , S. Palumbo , F. Bosia , N. M. Pugno

Evaluating the mechanical response of fiber-reinforced composites can be extremely time consuming and expensive. Machine learning (ML) techniques offer a means for faster predictions via models trained on existing input-output pairs and…

Materials Science · Physics 2024-10-03 Yixuan Sun , Imad Hanhan , Michael D. Sangid , Guang Lin

In this paper, a mechanistic data-driven approach is proposed to accelerate structural topology optimization, employing an in-house developed finite element convolutional neural network (FE-CNN). Our approach can be divided into two stages:…

Machine Learning · Computer Science 2021-06-28 Tianle Yue , Hang Yang , Zongliang Du , Chang Liu , Khalil I. Elkhodary , Shan Tang , Xu Guo

Coupled multiphysics simulations for high-dimensional, large-scale problems can be prohibitively expensive due to their computational demands. This article presents a novel framework integrating a deep operator network (DeepONet) with the…

Computational Engineering, Finance, and Science · Computer Science 2025-09-03 Fouad M. Amin , Diab W. Abueidda , Panos Pantidis , Mostafa E. Mobasher

Soft materials such as rubbers, hydrogels, and biological tissues undergo damage in the form of stiffness degradation without apparent changes in their stress-free geometry. Accurate simulation of this behavior is critical in applications…

Computational Engineering, Finance, and Science · Computer Science 2026-04-07 Mark Wilkinson , Amirhossein Amiri-Hezaveh , Adrian Buganza Tepole

We present a new Integrated Finite Element Neural Network framework (I-FENN), with the objective to accelerate the numerical solution of nonlinear computational mechanics problems. We leverage the swift predictive capability of neural…

Computational Engineering, Finance, and Science · Computer Science 2022-12-02 Panos Pantidis , Mostafa E. Mobasher

The aim of this paper is to develop a multiscale hierarchical hybrid model based on finite element analysis and neural network computation to link mesoscopic scale (trabecular network level) and macroscopic (whole bone level) to simulate…

Medical Physics · Physics 2011-07-20 Ridha Hambli , Abdelwahed Barkaoui

A popular testbed for deep learning has been multimodal recognition of human activity or gesture involving diverse inputs such as video, audio, skeletal pose and depth images. Deep learning architectures have excelled on such problems due…

Neural and Evolutionary Computing · Computer Science 2017-07-05 Dhanesh Ramachandram , Michal Lisicki , Timothy J. Shields , Mohamed R. Amer , Graham W. Taylor

We introduce FENNIX (Force-Field-Enhanced Neural Network InteraXions), a hybrid approach between machine-learning and force-fields. We leverage state-of-the-art equivariant neural networks to predict local energy contributions and multiple…

Chemical Physics · Physics 2024-07-23 Thomas Plé , Louis Lagardère , Jean-Philip Piquemal

In this project, we present a deep neural network (DNN)-based biophysics model that uses multi-scale and uniform topological and electrostatic features to predict protein properties, such as Coulomb energies or solvation energies. The…

Machine Learning · Computer Science 2026-03-16 Elyssa Sliheet , Md Abu Talha , Weihua Geng

This study presents a computational optimisation framework of a hip implant through the development of a functionally graded biomimetic lattice structure, whose design was structurally optimised to limit stress shielding. The optimisation…

Medical Physics · Physics 2026-01-27 Mahtab Vafaeefar , Conall Quinn , Kevin M. Moerman , Ted J. Vaughan
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