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Multimodal large language models (MLLMs) hold significant potential in medical applications, including disease diagnosis and clinical decision-making. However, these tasks require highly accurate, context-sensitive, and professionally…

Computation and Language · Computer Science 2025-09-01 Meidan Ding , Jipeng Zhang , Wenxuan Wang , Cheng-Yi Li , Wei-Chieh Fang , Hsin-Yu Wu , Haiqin Zhong , Wenting Chen , Linlin Shen

Built on the power of LLMs, numerous multimodal large language models (MLLMs) have recently achieved remarkable performance on various vision-language tasks. However, most existing MLLMs and benchmarks primarily focus on single-image input…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Haowei Liu , Xi Zhang , Haiyang Xu , Yaya Shi , Chaoya Jiang , Ming Yan , Ji Zhang , Fei Huang , Chunfeng Yuan , Bing Li , Weiming Hu

Despite the advancements and impressive performance of Multimodal Large Language Models (MLLMs) on benchmarks, their effectiveness in real-world, long-context, and multi-image tasks is unclear due to the benchmarks' limited scope. Existing…

Computation and Language · Computer Science 2024-05-16 Dingjie Song , Shunian Chen , Guiming Hardy Chen , Fei Yu , Xiang Wan , Benyou Wang

Vision-threatening eye diseases pose a major global health burden, with timely diagnosis limited by workforce shortages and restricted access to specialized care. While multimodal large language models (MLLMs) show promise for medical image…

With the increasing integration of Multimodal Large Language Models (MLLMs) into the medical field, comprehensive evaluation of their performance in various medical domains becomes critical. However, existing benchmarks primarily assess…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Chenghanyu Zhang , Zekun Li , Peipei Li , Xing Cui , Shuhan Xia , Weixiang Yan , Yiqiao Zhang , Qianyu Zhuang

Multimodal large language models (MLLMs) demonstrate considerable potential in clinical diagnostics, a domain that inherently requires synthesizing complex visual and textual data alongside consulting authoritative medical literature.…

Computation and Language · Computer Science 2026-03-23 Yannian Gu , Zhongzhen Huang , Linjie Mu , Xizhuo Zhang , Shaoting Zhang , Xiaofan Zhang

We introduce MuirBench, a comprehensive benchmark that focuses on robust multi-image understanding capabilities of multimodal LLMs. MuirBench consists of 12 diverse multi-image tasks (e.g., scene understanding, ordering) that involve 10…

With the proliferation of Large Language Models (LLMs) in diverse domains, there is a particular need for unified evaluation standards in clinical medical scenarios, where models need to be examined very thoroughly. We present CliMedBench,…

Computation and Language · Computer Science 2024-10-07 Zetian Ouyang , Yishuai Qiu , Linlin Wang , Gerard de Melo , Ya Zhang , Yanfeng Wang , Liang He

Generalist Large Language Models (LLMs), such as GPT-4, have shown considerable promise in various domains, including medical diagnosis. Rare diseases, affecting approximately 300 million people worldwide, often have unsatisfactory clinical…

Computation and Language · Computer Science 2024-07-08 Xuanzhong Chen , Xiaohao Mao , Qihan Guo , Lun Wang , Shuyang Zhang , Ting Chen

Brain imaging analysis is crucial for diagnosing and treating brain disorders, and multimodal large language models (MLLMs) are increasingly supporting it. However, current brain imaging visual question-answering (VQA) benchmarks either…

Computer Vision and Pattern Recognition · Computer Science 2025-12-29 Zhihao Peng , Cheng Wang , Shengyuan Liu , Zhiying Liang , Zanting Ye , Minjie Ju , PeterYM Woo , Yixuan Yuan

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that…

Computation and Language · Computer Science 2026-04-16 Zhijie Bao , Fangke Chen , Licheng Bao , Chenhui Zhang , Wei Chen , Jiajie Peng , Zhongyu Wei

Endoscopic procedures are essential for diagnosing and treating internal diseases, and multi-modal large language models (MLLMs) are increasingly applied to assist in endoscopy analysis. However, current benchmarks are limited, as they…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Shengyuan Liu , Boyun Zheng , Wenting Chen , Zhihao Peng , Zhenfei Yin , Jing Shao , Jiancong Hu , Yixuan Yuan

Multimodal language models (MLMs) show promise for clinical decision support and diagnostic reasoning, raising the prospect of end-to-end automated medical image interpretation. However, clinicians are highly selective in adopting AI tools;…

Artificial Intelligence · Computer Science 2025-08-06 Mahtab Bigverdi , Wisdom Ikezogwo , Kevin Zhang , Hyewon Jeong , Mingyu Lu , Sungjae Cho , Linda Shapiro , Ranjay Krishna

Multimodal in-context learning (ICL) remains underexplored despite significant potential for domains such as medicine. Clinicians routinely encounter diverse, specialized tasks requiring adaptation from limited examples, such as drawing…

Despite rare diseases affecting 1 in 10 Americans, their differential diagnosis remains challenging. Due to their impressive recall abilities, large language models (LLMs) have been recently explored for differential diagnosis. Existing…

Artificial Intelligence · Computer Science 2026-01-21 Zilal Eiz AlDin , John Wu , Jeffrey Paul Fung , Jennifer King , Mya Watts , Lauren ONeill , Adam Richard Cross , Jimeng Sun

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

Medical image analysis is essential to clinical diagnosis and treatment, which is increasingly supported by multi-modal large language models (MLLMs). However, previous research has primarily focused on 2D medical images, leaving 3D images…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Fan Bai , Yuxin Du , Tiejun Huang , Max Q. -H. Meng , Bo Zhao

Advancements in Multimodal Large Language Models (MLLMs) have significantly improved medical task performance, such as Visual Question Answering (VQA) and Report Generation (RG). However, the fairness of these models across diverse…

Computer Vision and Pattern Recognition · Computer Science 2024-10-03 Peiran Wu , Che Liu , Canyu Chen , Jun Li , Cosmin I. Bercea , Rossella Arcucci

Multimodal large language models (LLMs) are increasingly used to generate dermatology diagnostic narratives directly from images. However, reliable evaluation remains the primary bottleneck for responsible clinical deployment. We introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yuhao Shen , Jiahe Qian , Shuping Zhang , Zhangtianyi Chen , Tao Lu , Juexiao Zhou

Multimodal large language models (MLLMs) have demonstrated powerful capabilities in general spatial understanding and reasoning. However, their fine-grained spatial understanding and reasoning capabilities in complex urban scenarios have…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Jun Zhang , Jie Feng , Long Chen , Junhui Wang , Zhicheng Liu , Depeng Jin , Yong Li
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