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Recently, therapeutic peptides have demonstrated great promise for cancer treatment. To explore powerful anticancer peptides, artificial intelligence (AI)-based approaches have been developed to systematically screen potential candidates.…

Quantitative Methods · Quantitative Biology 2025-04-16 Joshua Zhi En Tan , JunJie Wee , Xue Gong , Kelin Xia

The paper introduces PDSP-Bench, a novel benchmarking system designed for a systematic understanding of performance of parallel stream processing in a distributed environment. Such an understanding is essential for determining how Stream…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-16 Pratyush Agnihotri , Boris Koldehofe , Roman Heinrich , Carsten Binnig , Manisha Luthra

Medical text embedding models are foundational to a wide array of healthcare applications, ranging from clinical decision support and biomedical information retrieval to medical question answering, yet they remain hampered by two critical…

Computation and Language · Computer Science 2025-08-07 Mohammad Khodadad , Ali Shiraee Kasmaee , Mahdi Astaraki , Hamidreza Mahyar

Therapeutic peptides have emerged as a pivotal modality in modern drug discovery, occupying a chemically and topologically rich space. While accurate prediction of their physicochemical properties is essential for accelerating peptide…

Machine Learning · Computer Science 2025-12-30 Seungeon Lee , Takuto Koyama , Itsuki Maeda , Shigeyuki Matsumoto , Yasushi Okuno

While Large Language Models (LLMs) are reshaping the paradigm of AI for Social Science (AI4SS), rigorously evaluating their capabilities in scholarly writing remains a major challenge. Existing benchmarks largely emphasize single-shot,…

Computation and Language · Computer Science 2026-02-18 Houping Yue , Zixiang Di , Mei Jiang , Bingdong Li , Hao Hao , Yu Song , Bo Jiang , Aimin Zhou

Imbalanced learning remains a fundamental challenge in tabular data applications. Despite decades of research and numerous proposed algorithms, a systematic empirical understanding of how different imbalanced learning methods behave across…

Machine Learning · Computer Science 2026-05-15 Ruizhe Liu , Jiaqi Luo

Embodied AI development significantly lags behind large foundation models due to three critical challenges: (1) lack of systematic understanding of core capabilities needed for Embodied AI, making research lack clear objectives; (2) absence…

Millions of individuals' well-being are challenged by the harms of substance use. Harm reduction as a public health strategy is designed to improve their health outcomes and reduce safety risks. Some large language models (LLMs) have…

Computation and Language · Computer Science 2025-07-30 Kaixuan Wang , Chenxin Diao , Jason T. Jacques , Zhongliang Guo , Shuai Zhao

Machine learning (ML) has become a vital part in many aspects of our daily life. However, building well performing machine learning applications requires highly specialized data scientists and domain experts. Automated machine learning…

Machine Learning · Computer Science 2021-01-27 Marc-André Zöller , Marco F. Huber

Landmark detection is central to many medical applications, such as identifying critical structures for treatment planning or defining control points for biometric measurements. However, manual annotation is labor-intensive and requires…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Alexandra Ertl , Stefan Denner , Robin Peretzke , Shuhan Xiao , David Zimmerer , Maximilian Fischer , Markus Bujotzek , Xin Yang , Peter Neher , Fabian Isensee , Klaus H. Maier-Hein

Multimodal LLMs (MLLMs) are capable of performing complex data analysis, visual question answering, generation, and reasoning tasks. However, their ability to analyze biometric data is relatively underexplored. In this work, we investigate…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Ekta Gavas , Sudipta Banerjee , Chinmay Hegde , Nasir Memon

Large Language Models (LLMs) have transformed how people interact with artificial intelligence (AI) systems, achieving state-of-the-art results in various tasks, including scientific discovery and hypothesis generation. However, the lack of…

Computation and Language · Computer Science 2024-11-06 Sikun Guo , Amir Hassan Shariatmadari , Guangzhi Xiong , Albert Huang , Eric Xie , Stefan Bekiranov , Aidong Zhang

The efficacy of availability poisoning, a method of poisoning data by injecting imperceptible perturbations to prevent its use in model training, has been a hot subject of investigation. Previous research suggested that it was difficult to…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Tianrui Qin , Xitong Gao , Juanjuan Zhao , Kejiang Ye , Cheng-Zhong Xu

Differentially private graph analysis is a powerful tool for deriving insights from diverse graph data while protecting individual information. Designing private analytic algorithms for different graph queries often requires starting from…

Databases · Computer Science 2024-12-10 Shang Liu , Hao Du , Yang Cao , Bo Yan , Jinfei Liu , Masatoshi Yoshikawa

Time series anomaly detection strives to uncover potential abnormal behaviors and patterns from temporal data, and has fundamental significance in diverse application scenarios. Constructing an effective detection model usually requires…

Machine Learning · Computer Science 2022-12-20 Fanxing Liu , Cheng Zeng , Le Zhang , Yingjie Zhou , Qing Mu , Yanru Zhang , Ling Zhang , Ce Zhu

The rapid expansion of large language model (LLM) safety evaluation has produced a substantial benchmark ecosystem, but not a correspondingly coherent measurement ecosystem. We present AISafetyBenchExplorer, a structured catalogue of 195 AI…

Artificial Intelligence · Computer Science 2026-04-24 Abiodun A. Solanke

Currently, the field of structure-based drug design is dominated by three main types of algorithms: search-based algorithms, deep generative models, and reinforcement learning. While existing works have typically focused on comparing models…

Machine Learning · Computer Science 2024-06-06 Kangyu Zheng , Yingzhou Lu , Zaixi Zhang , Zhongwei Wan , Yao Ma , Marinka Zitnik , Tianfan Fu

Training algorithms, broadly construed, are an essential part of every deep learning pipeline. Training algorithm improvements that speed up training across a wide variety of workloads (e.g., better update rules, tuning protocols, learning…

Scientific machine learning research spans diverse domains and data modalities, yet existing benchmark efforts remain siloed and lack standardization. This makes novel and transformative applications of machine learning to critical…

Given a long list of anomaly detection algorithms developed in the last few decades, how do they perform with regard to (i) varying levels of supervision, (ii) different types of anomalies, and (iii) noisy and corrupted data? In this work,…

Machine Learning · Computer Science 2022-09-20 Songqiao Han , Xiyang Hu , Hailiang Huang , Mingqi Jiang , Yue Zhao