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Advances in quantum technologies are accelerating the demand for optical quantum state sensors that combine high precision, versatility, and scalability within a unified hardware platform. Quantum reservoir computing offers a powerful route…

Molecular docking is an important tool for structure-based drug design, accelerating the efficiency of drug development. Complex and dynamic binding processes between proteins and small molecules require searching and sampling over a wide…

Chemical Physics · Physics 2024-02-23 Runqiu Shu , Bowen Liu , Zhaoping Xiong , Xiaopeng Cui , Yunting Li , Wei Cui , Man-Hong Yung , Nan Qiao

Many hybrid quantum-classical algorithms for the application of ground state energy estimation in quantum chemistry involve estimating the expectation value of a molecular Hamiltonian with respect to a quantum state through measurements on…

Many-electron problems pose some of the greatest challenges in computational science, with important applications across many fields of modern science. Fermionic quantum Monte Carlo (QMC) methods are among the most powerful approaches to…

Quantum computers have the potential to simulate chemical systems beyond the capability of classical computers. Recent developments in hybrid quantum-classical approaches enable the determinations of the ground or low energy states of…

Quantum Physics · Physics 2021-12-06 Chee-Kong Lee , Jonathan Wei Zhong Lau , Liang Shi , Leong Chuan Kwek

Quantum machine learning consists in taking advantage of quantum computations to generate classical data. A potential application of quantum machine learning is to harness the power of quantum computers for generating classical data, a…

Quantum Chemistry (QC) is one of the most promising applications of Quantum Computing. However, present quantum processing units (QPUs) are still subject to large errors. Therefore, noisy intermediate-scale quantum (NISQ) hardware is…

Quantum Physics · Physics 2025-10-21 Mohammad Haidar , Marko J. Rančić , Thomas Ayral , Yvon Maday , Jean-Philip Piquemal

Easy and effective usage of computational resources is crucial for scientific calculations. Following our recent work of machine-learning (ML) assisted scheduling optimization [Ref: J. Comput. Chem. 2023, 44, 1174], we further propose 1)…

Chemical Physics · Physics 2024-08-05 Kai Yuan , Shuai Zhou , Ning Li , Tianyan Li , Bowen Ding , Danhuai Guo , Yingjin Ma

Quantum Machine Learning (QML) algorithms to solve classifications problems have been made available thanks to recent advancements in quantum computation. While the number of qubits are still relatively small, they have been used for…

Quantum Physics · Physics 2020-12-08 Paul-Aymeric McRae , Michael Hilke

The practical application of quantum technologies to chemical problems faces significant challenges, particularly in the treatment of realistic basis sets and the accurate inclusion of electron correlation effects. A direct approach to…

The Quadratic Unconstrained Binary Optimization (QUBO) model has gained prominence in recent years with the discovery that it unifies a rich variety of combinatorial optimization problems. By its association with the Ising problem in…

Data Structures and Algorithms · Computer Science 2019-11-06 Fred Glover , Gary Kochenberger , Yu Du

Optimizing the properties of molecules (materials or drugs) for stronger toughness, lower toxicity, or better bioavailability has been a long-standing challenge. In this context, we propose a molecular optimization framework called Q-Drug…

Quantum Physics · Physics 2023-08-28 Zhaoping Xiong , Xiaopeng Cui , Xinyuan Lin , Feixiao Ren , Bowen Liu , Yunting Li , Manhong Yung , Nan Qiao

Quantum algorithms for simulating large and complex molecular systems are still in their infancy, and surpassing state-of-the-art classical techniques remains an ever-receding goal post. A promising avenue of inquiry in the meanwhile is to…

Quantum Physics · Physics 2025-08-07 Soohaeng Yoo Willow , D. ChangMo Yang , Chang Woo Myung

We introduce QC-CBT-AFQMC, a hybrid algorithm that incorporates computational basis tomography (CBT) into the quantum-classical auxiliary-field quantum Monte Carlo (QC-AFQMC) method proposed by Huggins et al. [Nature 603, 416-420 (2022)],…

Quantum Physics · Physics 2025-12-30 Viktor Khinevich , Wataru Mizukami

A brain-computer interface (BCI) system enables direct communication between the brain and external devices, offering significant potential for assistive technologies and advanced human-computer interaction. Despite progress, BCI systems…

Quantum Physics · Physics 2025-05-21 Bikash K. Behera , Saif Al-Kuwari , Ahmed Farouk

Demonstrating the practical utility of Noisy Intermediate-Scale Quantum (NISQ) hardware for recurrent tasks in Computer-Aided Drug Discovery is of paramount importance. We tackle this challenge by performing three-dimensional protein…

Quantum Physics · Physics 2025-12-12 Daniele Loco , Kisa Barkemeyer , Andre R. R. Carvalho , Jean-Philip Piquemal

People are witnessing quantum computing revolutions nowadays. Progress in the number of qubits, coherence times and gate fidelities are happening. Although quantum error correction era has not arrived, the research and development of…

Quantum Physics · Physics 2023-10-17 Guanru Feng , Dawei Lu , Jun Li , Tao Xin , Bei Zeng

Simulating correlated materials on present-day quantum hardware remains challenging due to limited quantum resources. Quantum embedding methods offer a promising route by reducing computational complexity through the mapping of bulk systems…

Quantum computational chemistry has emerged as an important application of quantum computing. Hybrid quantum-classical computing methods, such as variational quantum eigensolvers (VQE), have been designed as promising solutions to quantum…

Model quantization has emerged as an indispensable technique to accelerate deep learning inference. While researchers continue to push the frontier of quantization algorithms, existing quantization work is often unreproducible and…

Machine Learning · Computer Science 2022-01-26 Yuhang Li , Mingzhu Shen , Jian Ma , Yan Ren , Mingxin Zhao , Qi Zhang , Ruihao Gong , Fengwei Yu , Junjie Yan
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