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Classical machine learning (CML) has been extensively studied for malware classification. With the emergence of quantum computing, quantum machine learning (QML) presents a paradigm-shifting opportunity to improve malware detection, though…

Machine Learning · Computer Science 2025-08-28 Jesus Lopez , Saeefa Rubaiyet Nowmi , Viviana Cadena , Mohammad Saidur Rahman

Modern cyberattacks are increasingly complex, posing significant challenges to classical machine learning methods, particularly when labeled data is limited and feature interactions are highly non-linear. In this study we investigates the…

Cryptography and Security · Computer Science 2026-01-06 Jessica A. Sciammarelli , Waqas Ahmed

Quantitative Structure-Activity Relationship (QSAR) modeling is key in drug discovery, but classical methods face limitations when handling high-dimensional data and capturing complex molecular interactions. This research proposes enhancing…

Quantum Physics · Physics 2025-07-09 Alejandro Giraldo , Daniel Ruiz , Mariano Caruso , Guido Bellomo

This study explores the application of quantum machine learning (QML) algorithms to enhance cybersecurity threat detection, particularly in the classification of malware and intrusion detection within high-dimensional datasets. Classical…

Cryptography and Security · Computer Science 2025-09-09 Tanya Joshi , Krishnendu Guha

Quantum Computing (QC) offers outstanding potential for molecular characterization and drug discovery, particularly in solving complex properties like the Ground State Energy (GSE) of biomolecules. However, QC faces challenges due to…

Chemical Physics · Physics 2024-12-17 Laia Coronas Sala , Parfait Atchade-Adelemou

We introduce a parallel, GPU-accelerated implementation of the iterative qubit coupled cluster (iQCC) method that overcomes the exponential growth of the transformed Hamiltonian -- the principal bottleneck for classical emulation of quantum…

Quantum Physics · Physics 2026-03-11 Seyyed Mehdi Hosseini Jenab , Brandon Henderson , Scott N. Genin

Accurately predicting response properties of molecules such as the dynamic polarizability and hyperpolarizability using quantum mechanics has been a long-standing challenge with widespread applications in material and drug design. Classical…

Chemical Physics · Physics 2020-09-01 Xiaoxia Cai , Wei-Hai Fang , Heng Fan , Zhendong Li

We present a large-scale experimental study of quantum-computing-based molecular simulation carried out on IQM's Sirius 24-qubit superconducting processor, utilizing up to 16 operational qubits. The work employs Sample-based Quantum…

Detecting unseen ransomware is a critical cybersecurity challenge where classical machine learning often fails. While Quantum Machine Learning (QML) presents a potential alternative, its application is hindered by the dimensionality gap…

Quantum Physics · Physics 2025-09-10 Huu Phu Le , Phuc Hao Do , Vo Hoang Long Nguyen , Nang Hung Van Nguyen

Quantum computers can be used to address molecular structure, materials science and condensed matter physics problems, which currently stretch the limits of existing high-performance computing resources. Finding exact numerical solutions to…

Quantum computing is a rapidly emerging and promising field that has the potential to revolutionize numerous research domains, including drug design, network technologies and sustainable energy. Due to the inherent complexity and divergence…

Advancements in the implementation of quantum hardware have enabled the acquisition of data that are intractable for emulation with classical computers. The integration of classical machine learning (ML) algorithms with these data holds…

Quantum Physics · Physics 2025-01-22 Gyungmin Cho , Dohun Kim

Quantum machine learning (QML) is an emerging field of research that leverages quantum computing to improve the classical machine learning approach to solve complex real world problems. QML has the potential to address cybersecurity related…

Cancer is one of the leading causes of death worldwide. It is caused by a variety of genetic mutations, which makes every instance of the disease unique. Since chemotherapy can have extremely severe side effects, each patient requires a…

Molecular docking plays a crucial role in predicting the binding mode of ligands to target proteins, and covalent interactions, which involve the formation of a covalent bond between the ligand and the target, are particularly valuable due…

Biomolecules · Quantitative Biology 2025-06-27 Yangzhe Peng , Kaiyuan Gao , Liang He , Yuheng Cong , Haiguang Liu , Kun He , Lijun Wu

Machine Learning (ML) has been widely applied across numerous domains due to its ability to automatically identify informative patterns from data for various tasks. The availability of large-scale data and advanced computational power…

Quantum computing has become increasingly practical in solving real-world problems due to advances in hardware and algorithms. In this paper, we aim to design and estimate quantum machine learning and hybrid quantum-classical models in a…

Quantum Physics · Physics 2025-07-14 Leyang Wang , Yilun Gong , Zongrui Pei

Quantum annealing offers a promising paradigm for solving NP-hard combinatorial optimization problems, but its practical application is severely hindered by two challenges: the complex, manual process of translating problem descriptions…

Machine Learning · Computer Science 2025-09-03 Huixiang Zhang , Mahzabeen Emu , Salimur Choudhury

Assessing cyber risk in complex IT infrastructures poses significant challenges due to the dynamic, interconnected nature of digital systems. Traditional methods often fall short, relying on static and largely qualitative models that do not…

Quantum Physics · Physics 2026-04-22 Remo Marini , Riccardo Arpe

We present an approach to combine novel molecular features with experimental data within a data-driven pipeline. The method is applied to the challenge of predicting the reactivity of a series of sulfonyl fluoride molecular fragments used…