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Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis…

Computation and Language · Computer Science 2025-05-21 Kevin Wu , Eric Wu , Rahul Thapa , Kevin Wei , Angela Zhang , Arvind Suresh , Jacqueline J. Tao , Min Woo Sun , Alejandro Lozano , James Zou

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Due to the high stakes in medical decision-making, there is a compelling demand for interpretable deep learning methods in medical image analysis. Concept Bottleneck Models (CBM) have emerged as an active interpretable framework…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Yibo Gao , Zheyao Gao , Xin Gao , Yuanye Liu , Bomin Wang , Xiahai Zhuang

Pre-consultation is a critical component of effective healthcare delivery. However, generating comprehensive pre-consultation questionnaires from complex, voluminous Electronic Medical Records (EMRs) is a challenging task. Direct Large…

Artificial Intelligence · Computer Science 2025-08-04 Ruiqing Ding , Qianfang Sun , Yongkang Leng , Hui Yin , Xiaojian Li

Large language models (LLMs) are prone to hallucination stemming from misaligned self-awareness, particularly when processing queries exceeding their knowledge boundaries. While existing mitigation strategies employ uncertainty estimation…

Computation and Language · Computer Science 2025-10-10 Hang Zheng , Hongshen Xu , Yuncong Liu , Lu Chen , Pascale Fung , Kai Yu

Reliable epidemiological reasoning requires synthesizing study evidence to infer disease burden, transmission dynamics, and intervention effects at the population level. Existing medical question answering benchmarks primarily emphasize…

Computation and Language · Computer Science 2026-05-27 Mingyang Wei , Dehai Min , Zewen Liu , Yuzhang Xie , Guanchen Wu , Ziyang Zhang , Carl Yang , Max S. Y. Lau , Qi He , Lu Cheng , Wei Jin

Recent advances in deep learning (DL) have prompted the development of high-performing early warning score (EWS) systems, predicting clinical deteriorations such as acute kidney injury, acute myocardial infarction, or circulatory failure.…

Machine Learning · Computer Science 2025-02-05 Yuxiao Cheng , Xinxin Song , Ziqian Wang , Qin Zhong , Kunlun He , Jinli Suo

Large language model (LLM) systems are increasingly used to support high-stakes decision-making, but they typically perform worse when the available evidence is internally inconsistent. Such a scenario exists in real-world healthcare…

Computation and Language · Computer Science 2026-04-02 Haochen Liu , Weien Li , Rui Song , Zeyu Li , Chun Jason Xue , Xiao-Yang Liu , Sam Nallaperuma , Xue Liu , Ye Yuan

Electronic Health Records (EHRs) provide rich longitudinal clinical evidence that is central to medical decision-making, motivating the use of retrieval-augmented generation (RAG) to ground large language model (LLM) predictions. However,…

Artificial Intelligence · Computer Science 2026-01-30 Lang Cao , Qingyu Chen , Yue Guo

Large vision-language models (LVLMs) demonstrate strong performance in dermatology; however, evaluating diagnostic reasoning for rare conditions remains largely unexplored. Existing benchmarks focus on common diseases and assess only final…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Yang Liu , Jiyao Yang , Hongjin Zhao , Xiaoyong Li , Yanzhe Ji , Xingjian Li , Runmin Jiang , Tianyang Wang , Saeed Anwar , Dongwoo Kim , Yue Yao , Zhenyue Qin , Min Xu

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

Machine Learning · Computer Science 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

Medical vision-language models (VLMs) show strong performance on radiology tasks but often produce fluent yet weakly grounded conclusions due to over-reliance on a dominant modality. We introduce a context-aligned reasoning framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Sumra Khan , Sagar Chhabriya , Aizan Zafar , Sheeraz Arif , Amgad Muneer , Anas Zafar , Shaina Raza , Rizwan Qureshi

Clinical Reasoning on Electronic Health Records (EHRs) is a fundamental yet challenging task in modern healthcare. While in-context learning (ICL) offers a promising inference-time adaptation paradigm for large language models (LLMs) in EHR…

Machine Learning · Computer Science 2026-04-09 Yue Fang , Weibin Liao , Yuxin Guo , Jiaran Gao , Hongxin Ding , Jinyang Zhang , Xinke Jiang , Zhibang Yang , Junfeng Zhao , Yasha Wang , Liantao Ma

Large language models (LLMs) often struggle with context fidelity, producing inconsistent answers when responding to questions based on provided information. Existing approaches either rely on expensive supervised fine-tuning to generate…

Computation and Language · Computer Science 2025-09-18 Suyuchen Wang , Jinlin Wang , Xinyu Wang , Shiqi Li , Xiangru Tang , Sirui Hong , Xiao-Wen Chang , Chenglin Wu , Bang Liu

Medical Large Vision-Language Models (Med-LVLMs) demonstrate significant potential in healthcare, but their reliance on general medical data and coarse-grained global visual understanding limits them in intelligent ophthalmic diagnosis.…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Sijing Li , Tianwei Lin , Lingshuai Lin , Wenqiao Zhang , Jiang Liu , Xiaoda Yang , Juncheng Li , Yucheng He , Xiaohui Song , Jun Xiao , Yueting Zhuang , Beng Chin Ooi

Rare diseases affect hundreds of millions worldwide, yet diagnosis often spans years. Convectional pipelines decouple noisy evidence extraction from downstream inferential diagnosis, and general/medical large language models (LLMs) face…

Detecting Alzheimer's Disease (AD) from narrative transcripts remains a challenging task for large language models (LLMs), particularly under out-of-distribution (OOD) and data-scarce conditions. While in-context learning (ICL) provides a…

Computation and Language · Computer Science 2025-11-11 Puzhen Su , Yongzhu Miao , Chunxi Guo , Jintao Tang , Shasha Li , Ting Wang

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Interactive medical consultation requires an agent to proactively elicit missing clinical evidence under uncertainty. Yet existing evaluations largely remain static or outcome-centric, neglecting the evidence-gathering process. In this…

Computation and Language · Computer Science 2026-01-28 Zhuohan Long , Zhijie Bao , Zhongyu Wei

We introduce ColaCare, a framework that enhances Electronic Health Record (EHR) modeling through multi-agent collaboration driven by Large Language Models (LLMs). Our approach seamlessly integrates domain-specific expert models with LLMs to…