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Safe and trustworthy use of Large Language Models (LLM) in the processing of healthcare documents and scientific papers could substantially help clinicians, scientists and policymakers in overcoming information overload and focusing on the…

Retrieval augmented generation (RAG) systems provide a method for factually grounding the responses of a Large Language Model (LLM) by providing retrieved evidence, or context, as support. Guided by this context, RAG systems can reduce…

Information Retrieval · Computer Science 2025-09-05 Shakiba Amirshahi , Amin Bigdeli , Charles L. A. Clarke , Amira Ghenai

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice.…

Artificial Intelligence · Computer Science 2025-11-18 Silas Ruhrberg Estévez , Nicolás Astorga , Mihaela van der Schaar

The emergent abilities of large language models (LLMs) have demonstrated great potential in solving medical questions. They can possess considerable medical knowledge, but may still hallucinate and are inflexible in the knowledge updates.…

Computation and Language · Computer Science 2024-10-14 Guangzhi Xiong , Qiao Jin , Xiao Wang , Minjia Zhang , Zhiyong Lu , Aidong Zhang

Retrieval-augmented Generation (RAG) has demonstrated potential in enhancing medical question-answering systems through the integration of large language models (LLMs) with external medical literature. LLMs can retrieve relevant medical…

Computation and Language · Computer Science 2025-10-29 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bin Qin

Multi-document Multi-entity Question Answering inherently demands models to track implicit logic between multiple entities across scattered documents. However, existing Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG)…

Artificial Intelligence · Computer Science 2026-03-13 Teng Lin , Yizhang Zhu , Zhengxuan Zhang , Yuyu Luo , Nan Tang

The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…

Quantitative Methods · Quantitative Biology 2025-10-07 Satrio Pambudi , Filippo Menolascina

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating their parametric knowledge with external retrieved content. However, knowledge conflicts caused by internal inconsistencies or noisy retrieved content…

Computation and Language · Computer Science 2025-07-03 Juan Chen , Baolong Bi , Wei Zhang , Jingyan Sui , Xiaofei Zhu , Yuanzhuo Wang , Lingrui Mei , Shenghua Liu

In recent years, accurately and quickly deploying medical large language models (LLMs) has become a trend. Among these, retrieval-augmented generation (RAG) has garnered attention due to rapid deployment and privacy protection. However, the…

Computation and Language · Computer Science 2025-08-06 Penglei Sun , Yixiang Chen , Xiang Li , Xiaowen Chu

Retrieval-Augmented Generation (RAG) methods augment the input of Large Language Models (LLMs) with relevant retrieved passages, reducing factual errors in knowledge-intensive tasks. However, contemporary RAG approaches suffer from…

Computation and Language · Computer Science 2024-05-24 Dian Jiao , Li Cai , Jingsheng Huang , Wenqiao Zhang , Siliang Tang , Yueting Zhuang

Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for…

Information Retrieval · Computer Science 2026-01-14 Linus Stuhlmann , Michael Alexander Saxer , Jonathan Fürst

Trustworthy biomedical question answering (QA) systems must not only provide accurate answers but also justify them with current, verifiable evidence. Retrieval-augmented approaches partially address this gap but lack mechanisms to…

Computation and Language · Computer Science 2026-03-31 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Biomedical retrieval-augmented generation (RAG) can ground LLM answers in medical literature, yet long-form outputs often contain isolated unsupported or contradictory claims with safety implications. We introduce MedRAGChecker, a…

Computation and Language · Computer Science 2026-01-13 Yuelyu Ji , Min Gu Kwak , Hang Zhang , Xizhi Wu , Chenyu Li , Yanshan Wang

This work presents a Biomedical Literature Question Answering (Q&A) system based on a Retrieval-Augmented Generation (RAG) architecture, designed to improve access to accurate, evidence-based medical information. Addressing the shortcomings…

Computation and Language · Computer Science 2025-09-09 Mansi Garg , Lee-Chi Wang , Bhavesh Ghanchi , Sanjana Dumpala , Shreyash Kakde , Yen Chih Chen

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Context: Large Language Model (LLM) agents are becoming widely used for various Requirements Engineering (RE) tasks. Research on improving their accuracy mainly focuses on prompt engineering, model fine-tuning, and retrieval augmented…

Software Engineering · Computer Science 2025-11-20 Marc Oriol , Quim Motger , Jordi Marco , Xavier Franch

Retrieval-augmented generation (RAG) has proven highly effective in improving large language models (LLMs) across various domains. However, there is no benchmark specifically designed to assess the effectiveness of RAG in the legal domain,…

Computation and Language · Computer Science 2025-03-03 Haitao Li , Yifan Chen , Yiran Hu , Qingyao Ai , Junjie Chen , Xiaoyu Yang , Jianhui Yang , Yueyue Wu , Zeyang Liu , Yiqun Liu

Retrieval-Augmented Generation (RAG) offers a well-established path to grounding large language model (LLM) outputs in external knowledge, yet the question of which retrieval strategy works best in a high-stakes domain such as biomedicine…

Computation and Language · Computer Science 2026-05-05 Devi Prasad Bal , Subhashree Puhan