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There are concerns about the fairness of clinical prediction models. 'Fair' models are defined as those for which their performance or predictions are not inappropriately influenced by protected attributes such as ethnicity, gender, or…

Applications · Statistics 2024-12-12 Jose Benitez-Aurioles , Alice Joules , Irene Brusini , Niels Peek , Matthew Sperrin

Confounding pathology with normal anatomical variation remains a significant challenge in unsupervised medical-image anomaly detection, resulting in numerous false positives. To enhance integration of healthy variation, we augment the…

Quantitative Methods · Quantitative Biology 2026-03-09 P. Bilha Githinji , Xi Yuan , Ijaz Gul , Lian Zhang , Jinhao Xu , Zhenglin Chen , Peiwu Qin , Dongmei Yu

Medical artificial intelligence (AI) systems, particularly multimodal vision-language models (VLM), often exhibit intersectional biases where models are systematically less confident in diagnosing marginalised patient subgroups. Such bias…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Yupeng Zhang , Adam G. Dunn , Usman Naseem , Jinman Kim

Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Majid Behzadpour , Bengie L. Ortiz , Ebrahim Azizi , Kai Wu

Automated gender classification has important applications in many domains, such as demographic research, law enforcement, online advertising, as well as human-computer interaction. Recent research has questioned the fairness of this…

Computer Vision and Pattern Recognition · Computer Science 2020-09-25 Anoop Krishnan , Ali Almadan , Ajita Rattani

Detection of pulmonary nodules in chest CT imaging plays a crucial role in early diagnosis of lung cancer. Manual examination is highly time-consuming and error prone, calling for computer-aided detection, both to improve efficiency and…

Computer Vision and Pattern Recognition · Computer Science 2018-07-17 Zhongliu Xie

Machine learning models have achieved high overall accuracy in medical image analysis. However, performance disparities on specific patient groups pose challenges to their clinical utility, safety, and fairness. This can affect known…

Machine Learning · Computer Science 2024-10-23 Vincent Olesen , Nina Weng , Aasa Feragen , Eike Petersen

With the spread of COVID-19 over the world, the need arose for fast and precise automatic triage mechanisms to decelerate the spread of the disease by reducing human efforts e.g. for image-based diagnosis. Although the literature has shown…

Artificial intelligence based predictive models trained on the clinical notes can be demographically biased. This could lead to adverse healthcare disparities in predicting outcomes like length of stay of the patients. Thus, it is necessary…

Machine Learning · Computer Science 2024-11-21 Ankita Agarwal , Tanvi Banerjee , William Romine , Mia Cajita

Recent advancements in deep learning have shown transformative potential in medical imaging, yet concerns about fairness persist due to performance disparities across demographic subgroups. Existing methods aim to address these biases by…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Yicheng Gao , Jinkui Hao , Bo Zhou

Deep learning models have reached or surpassed human-level performance in the field of medical imaging, especially in disease diagnosis using chest x-rays. However, prior work has found that such classifiers can exhibit biases in the form…

Machine Learning · Computer Science 2022-03-24 Haoran Zhang , Natalie Dullerud , Karsten Roth , Lauren Oakden-Rayner , Stephen Robert Pfohl , Marzyeh Ghassemi

Anomaly detection (AD) has been widely studied for decades in many real-world applications, including fraud detection in finance, and intrusion detection for cybersecurity, etc. Due to the imbalanced nature between protected and unprotected…

Machine Learning · Computer Science 2024-09-18 Ziwei Wu , Lecheng Zheng , Yuancheng Yu , Ruizhong Qiu , John Birge , Jingrui He

Fairness in clinical prediction models remains a persistent challenge, particularly in high-stakes applications such as spinal fusion surgery for scoliosis, where patient outcomes exhibit substantial heterogeneity. Many existing fairness…

Machine Learning · Computer Science 2025-12-02 Yining Yuan , J. Ben Tamo , Wenqi Shi , Yishan Zhong , Micky C. Nnamdi , B. Randall Brenn , Steven W. Hwang , May D. Wang

Many works have shown that deep learning-based medical image classification models can exhibit bias toward certain demographic attributes like race, gender, and age. Existing bias mitigation methods primarily focus on learning debiased…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Yawen Wu , Dewen Zeng , Xiaowei Xu , Yiyu Shi , Jingtong Hu

Fair regression methods have the potential to mitigate societal bias concerns in health care, but there has been little work on penalized fair regression when multiple groups experience such bias. We propose a general regression framework…

Methodology · Statistics 2026-01-15 Carter H. Nakamoto , Lucia Lushi Chen , Agata Foryciarz , Sherri Rose

Diagnostic performance in medical AI varies systematically across demographic groups, yet subgroup AUC can mask clinically important disparities. At a fixed inference-time operating point, some groups may exhibit over-diagnostic behaviour,…

Face gender classification models often reflect and amplify demographic biases present in their training data, leading to uneven performance across gender and racial subgroups. We introduce pseudo-balancing, a simple and effective strategy…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Haohua Dong , Ana Manzano Rodríguez , Camille Guinaudeau , Shin'ichi Satoh

Radiologists routinely detect and size lesions in CT to stage cancer and assess tumor burden. To potentially aid their efforts, multiple lesion detection algorithms have been developed with a large public dataset called DeepLesion (32,735…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Peter D. Erickson , Tejas Sudharshan Mathai , Ronald M. Summers

Chest X-rays (X-ray images) have been proven to be effective for the diagnosis of chest diseases, including Pneumonia, Lung Opacity, and COVID-19. However, relying on traditional medical methods for diagnosis from X-ray images is prone to…

Image and Video Processing · Electrical Eng. & Systems 2025-10-01 Omar Hesham Khater , Abdullahi Sani Shuaib , Sami Ul Haq , Abdul Jabbar Siddiqui

Chest radiograph (CXR) interpretation in pediatric patients is error-prone and requires a high level of understanding of radiologic expertise. Recently, deep convolutional neural networks (D-CNNs) have shown remarkable performance in…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Thanh T. Tran , Hieu H. Pham , Thang V. Nguyen , Tung T. Le , Hieu T. Nguyen , Ha Q. Nguyen