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We study the composability of discrete chemical reaction networks (CRNs) that stably compute (i.e., with probability 0 of error) integer-valued functions $f:\mathbb{N}^d\to\mathbb{N}$. We consider output-oblivious CRNs in which the output…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-06-04 Eric E. Severson , David Haley , David Doty

Quantum chemical calculations on atomistic systems have evolved into a standard approach to study molecular matter. These calculations often involve a significant amount of manual input and expertise although most of this effort could be…

Machine learning techniques applied to chemical reactions has a long history. The present contribution discusses applications ranging from small molecule reaction dynamics to platforms for reaction planning. ML-based techniques can be of…

Chemical Physics · Physics 2021-01-12 M. Meuwly

Biochemical systems are inherently stochastic, particularly those with small-molecule populations. The spatial distribution of molecules plays a critical role and requires the inclusion of spatial coordinates in their analysis. Stochastic…

Molecular Networks · Quantitative Biology 2025-05-15 Manuel Eduardo Hernández-García , Eduardo Moreno-Barbosa , Jorge Velázquez-Castro

We introduce a new model of \emph{step} Chemical Reaction Networks (step CRNs), motivated by the step-wise addition of materials in standard lab procedures. Step CRNs have ordered reactants that transform into products via reaction rules…

Conventional computing paradigm struggles to fulfill the rapidly growing demands from emerging applications, especially those for machine intelligence, because much of the power and energy is consumed by constant data transfers between…

Quantum arithmetic in the computational basis constitutes the fundamental component of many circuit-based quantum algorithms. There exist a lot of studies about reversible implementations of algebraic functions, while research on the…

Quantum Physics · Physics 2021-08-24 Shengbin Wang , Zhimin Wang , Wendong Li , Lixin Fan , Guolong Cui , Zhiqiang Wei , Yongjian Gu

The software for chemical interaction networks (SCINE) project aims at pushing the frontier of quantum chemical calculations on molecular structures to a new level. While calculations on individual structures as well as on simple relations…

Quantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant…

Recent advances in convolutional neural networks have considered model complexity and hardware efficiency to enable deployment onto embedded systems and mobile devices. For example, it is now well-known that the arithmetic operations of…

Neural and Evolutionary Computing · Computer Science 2016-03-18 Daisuke Miyashita , Edward H. Lee , Boris Murmann

We obtain some new results on the unimodal sequences of the real values of rational functions by polynomials with positive integer coefficients. Thus, we introduce the notion of merged-log-concavity of rational functions. Roughly speaking,…

Combinatorics · Mathematics 2024-01-31 So Okada

Convolutional neural networks are constructed with massive operations with different types and are highly computationally intensive. Among these operations, multiplication operation is higher in computational complexity and usually requires…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Yulan Guo , Longguang Wang , Wendong Mao , Xiaoyu Dong , Yingqian Wang , Li Liu , Wei An

The convergence to equilibrium of mass action reaction-diffusion systems arising from networks of chemical reactions is studied. The considered reaction networks are assumed to satisfy the detailed balance condition and have no boundary…

Analysis of PDEs · Mathematics 2017-02-13 Klemens Fellner , Bao Quoc Tang

Computational efficiency and robustness are essential in process modeling, optimization, and control for real-world engineering applications. While neural network-based approaches have gained significant attention in recent years,…

Machine Learning · Computer Science 2026-03-17 Zihao Wang , Yuhan Li , Yao Shi , Zhe Wu

Linear Response theory aims to predict how added forcing alters the statistical properties of an unforced system. These kinds of questions have been studied predominantly for autonomous dynamical systems, yet many systems in the physical,…

Dynamical Systems · Mathematics 2026-04-07 Stefano Galatolo , Valerio Lucarini

While most work on the quantum simulation of chemistry has focused on computing energy surfaces, a similarly important application requiring subtly different algorithms is the computation of energy derivatives. Almost all molecular…

Inferring parameters of models of biochemical kinetics from single-cell data remains challenging because of the uncertainty arising from the intractability of the likelihood function of stochastic reaction networks. Such uncertainty falls…

Quantitative Methods · Quantitative Biology 2025-01-14 Zekai Li , Mauricio Barahona , Philipp Thomas

In this paper, we provide a graphic formulation of non-isothermal reaction systems and show that a non-isothermal detailed balanced network system converges (locally) asymptotically to the unique equilibrium within the invariant manifold…

Dynamical Systems · Mathematics 2020-10-01 Zhou Fang , Arjan van der Schaft , Chuanhou Gao

Quantum computing offers the promise of speedups for scientific computations, but its application to reacting flows is hindered by nonlinear source terms, the challenges of time-dependent simulations, and the difficulty of extracting…

Quantum Physics · Physics 2026-03-17 Jizhi Zhang , Ziang Yang , Zhaoyuan Meng , Zhen Lu , Yue Yang

Simulating chemical reaction networks is often computationally demanding, in particular due to stiffness. We propose a novel simulation scheme where long runs are not simulated as a whole but assembled from shorter precomputed segments of…

Logic in Computer Science · Computer Science 2022-06-22 Martin Helfrich , Milan Češka , Jan Křetínský , Štefan Martiček