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Related papers: EvoLen: Evolution-Guided Tokenization for DNA Lang…

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DNA language models have advanced genomics, but their downstream performance varies widely due to differences in tokenization, pretraining data, and architecture. We argue that a major bottleneck lies in tokenizing sparse and unevenly…

Genomics · Quantitative Biology 2025-12-23 Xiaoxiao Zhou , Zihan Wang , Jingbo Shang , Yang E. Li

DNA language models are increasingly used to represent genomic sequence, yet their effectiveness depends critically on how raw nucleotides are converted into model inputs. Unlike natural language, DNA offers no canonical boundaries, making…

Genomics · Quantitative Biology 2026-05-21 Taewon Kim , Jihwan Shin , Hyomin Kim , Youngmok Jung , Jonghoon Lee , Won-Chul Lee , Sungsoo Ahn , Insu Han

Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed for natural language, which are unsuitable for DNA sequences…

Genomics · Quantitative Biology 2024-12-19 Lifeng Qiao , Peng Ye , Yuchen Ren , Weiqiang Bai , Chaoqi Liang , Xinzhu Ma , Nanqing Dong , Wanli Ouyang

Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…

Genomics · Quantitative Biology 2025-11-20 Siyuan Li , Kai Yu , Anna Wang , Zicheng Liu , Chang Yu , Jingbo Zhou , Qirong Yang , Yucheng Guo , Xiaoming Zhang , Stan Z. Li

As a cornerstone in language modeling, tokenization involves segmenting text inputs into pre-defined atomic units. Conventional statistical tokenizers often disrupt constituent boundaries within words, thereby corrupting semantic…

Computation and Language · Computer Science 2025-07-11 Qingyang Zhu , Xiang Hu , Pengyu Ji , Wei Wu , Kewei Tu

Tokenization is a foundational step in natural language processing (NLP) tasks, bridging raw text and language models. Existing tokenization approaches like Byte-Pair Encoding (BPE) originate from the field of data compression, and it has…

Computation and Language · Computer Science 2024-10-08 Craig W. Schmidt , Varshini Reddy , Haoran Zhang , Alec Alameddine , Omri Uzan , Yuval Pinter , Chris Tanner

Tokenization underlies every large language model, yet it remains an under-theorized and inconsistently designed component. Common subword approaches such as Byte Pair Encoding (BPE) offer scalability but often misalign with linguistic…

Computation and Language · Computer Science 2026-01-27 Sawsan Alqahtani , Mir Tafseer Nayeem , Md Tahmid Rahman Laskar , Tasnim Mohiuddin , M Saiful Bari

Subword tokenization introduces a computational layer in language models where many distinct token sequences decode to the same surface form and preserve meaning, yet induce different internal computations. Despite this non-uniqueness,…

Computation and Language · Computer Science 2026-01-14 Adrian Cosma , Stefan Ruseti , Emilian Radoi , Mihai Dascalu

Genome modeling conventionally treats gene sequence as a language, reflecting its structured motifs and long-range dependencies analogous to linguistic units and organization principles such as words and syntax. Recent studies utilize…

Machine Learning · Computer Science 2025-05-06 Lei Mao , Yuanhe Tian , Yan Song

The development of unified multimodal large language models (MLLMs) is fundamentally challenged by the granularity gap between visual understanding and generation: understanding requires high-level semantic abstractions, while image…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Yan Li , Ning Liao , Xiangyu Zhao , Shaofeng Zhang , Xiaoxing Wang , Yifan Yang , Junchi Yan , Xue Yang

Tokenization is a necessary component within the current architecture of many language mod-els, including the transformer-based large language models (LLMs) of Generative AI, yet its impact on the model's cognition is often overlooked. We…

While large language models (LLMs) excel at static scientific reasoning, they struggle to model the temporal structure of dynamic physical processes. We present EvoMD-LLM (Evolutionary Molecular Dynamics Large Language Model), a framework…

Artificial Intelligence · Computer Science 2026-05-29 Zhichen Tang , Zhengzheng Dang , Yulin Chen , Jixin Wu , Haiwen Li , Yanming Wang

Recent advances in generative AI have been largely driven by large language models (LLMs), deep neural networks that operate over discrete units called tokens. To represent text, the vast majority of LLMs use words or word fragments as the…

Tokenization is the first step in modern neural language model pipelines where an input text is converted to a sequence of subword tokens. We introduce from first principles a finite-state transduction framework which can efficiently encode…

Computation and Language · Computer Science 2024-10-22 Marco Cognetta , Naoaki Okazaki

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers…

Genomic foundation models have the potential to decode DNA syntax, yet face a fundamental tradeoff in their input representation. Standard fixed-vocabulary tokenizers fragment biologically meaningful motifs such as codons and regulatory…

Tokenization - the practice of converting strings of characters from an alphabet into sequences of tokens over a vocabulary - is a critical step in the NLP pipeline. The use of token representations is widely credited with increased model…

Computation and Language · Computer Science 2025-04-04 Juan Luis Gastaldi , John Terilla , Luca Malagutti , Brian DuSell , Tim Vieira , Ryan Cotterell

Recent Multimodal Large Language Models (MLLMs) have demonstrated strong performance on vision-language understanding tasks, yet their inference efficiency is often hampered by the large number of visual tokens, particularly in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Jiafei Song , Fengwei Zhou , Jin Qu , Wenjin Jason Li , Tong Wu , Gengjian Xue , Zhikang Zhao , Daomin Wei , Yichao Lu , Bailin Na

Character-level language models obviate the need for separately trained tokenizers, but efficiency suffers from longer sequence lengths. Learning to combine character representations into tokens has made training these models more…

Computation and Language · Computer Science 2023-11-16 William Fleshman , Benjamin Van Durme

Tokenization is a crucial step in processing protein sequences for machine learning models, as proteins are complex sequences of amino acids that require meaningful segmentation to capture their functional and structural properties.…

Computation and Language · Computer Science 2024-11-27 Burak Suyunu , Enes Taylan , Arzucan Özgür
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