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This work presents a diffusion transformer framework for data-driven structural topology optimization that combines the accuracy of physics-based methods with the efficiency of generative deep learning. Conventional approaches such as the…

Computational Engineering, Finance, and Science · Computer Science 2026-05-05 Aaron Lutheran , Srijan Das , Alireza Tabarraei

This paper studies the challenging task of makeup transfer, which aims to apply diverse makeup styles precisely and naturally to a given facial image. Due to the absence of paired data, current methods typically synthesize sub-optimal…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Zhaoyang Sun , Shengwu Xiong , Yaxiong Chen , Fei Du , Weihua Chen , Fan Wang , Yi Rong

Image-to-image translation (I2I) methods allow the generation of artificial images that share the content of the original image but have a different style. With the advances in Generative Adversarial Networks (GANs)-based methods, I2I…

Image and Video Processing · Electrical Eng. & Systems 2023-04-07 Igor Zingman , Sergio Frayle , Ivan Tankoyeu , Segrey Sukhanov , Fabian Heinemann

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and…

Quantitative Methods · Quantitative Biology 2026-05-19 Yucheng Xing , Pei Liu , Jingying Ma , Ruping Hong , Jiangdong Qiu , Tianyu Liu , Kai He , Ling Huang , Mengling Feng

Immunohistochemical (IHC) staining enables precise molecular profiling of protein expression, with over 200 clinically available antibody-based tests in modern pathology. However, comprehensive IHC analysis is frequently limited by…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Fuqiang Chen , Ranran Zhang , Wanming Hu , Deboch Eyob Abera , Yue Peng , Boyun Zheng , Yiwen Sun , Jing Cai , Wenjian Qin

Medical Vision-language models (VLMs) have shown remarkable performances in various medical imaging domains such as histo\-pathology by leveraging pre-trained, contrastive models that exploit visual and textual information. However,…

The digitization of histology slides has revolutionized pathology, providing massive datasets for cancer diagnosis and research. Self-supervised and vision-language models have been shown to effectively mine large pathology datasets to…

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

In breast ultrasound images, precise lesion segmentation is essential for early diagnosis; however, low contrast, speckle noise, and unclear boundaries make this difficult. Even though deep learning models have demonstrated potential,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Prateek Singh , Moumita Dholey , P. K. Vinod

Immunohistochemical (IHC) virtual staining is a task that generates virtual IHC images from H\&E images while maintaining pathological semantic consistency with adjacent slices. This task aims to achieve cross-domain mapping between…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Yue Peng , Bing Xiong , Fuqiang Chen , De Eybo , RanRan Zhang , Wanming Hu , Jing Cai , Wenjian Qin

Histological analysis of tissue samples is one of the most widely used methods for disease diagnosis. After taking a sample from a patient, it goes through a lengthy and laborious preparation, which stains the tissue to visualize different…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Yair Rivenson , Hongda Wang , Zhensong Wei , Yibo Zhang , Harun Gunaydin , Aydogan Ozcan

Histopathological staining of human tissue is essential for disease diagnosis. Recent advances in virtual tissue staining technologies using artificial intelligence (AI) alleviate some of the costly and tedious steps involved in traditional…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Luzhe Huang , Yuzhu Li , Nir Pillar , Tal Keidar Haran , William Dean Wallace , Aydogan Ozcan

Image compression under ultra-low bitrates remains challenging for both conventional learned image compression (LIC) and generative vector-quantized (VQ) modeling. Conventional LIC suffers from severe artifacts due to heavy quantization,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Lei Lu , Yize Li , Yanzhi Wang , Wei Wang , Wei Jiang

The emergence of virtual staining technology provides a rapid and efficient alternative for researchers in tissue pathology. It enables the utilization of unlabeled microscopic samples to generate virtual replicas of chemically stained…

Image and Video Processing · Electrical Eng. & Systems 2025-01-08 Junjia Wang , Bo Xiong , You Zhou , Xun Cao , Zhan Ma

Computational pathology has made significant progress in recent years, fueling advances in both fundamental disease understanding and clinically ready tools. This evolution is driven by the availability of large amounts of digitized slides…

Immunohistochemical (IHC) staining highlights the molecular information critical to diagnostics in tissue samples. However, compared to H&E staining, IHC staining can be much more expensive in terms of both labor and the laboratory…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Fangda Li , Zhiqiang Hu , Wen Chen , Avinash Kak

The integrity of the reconstructed human epidermis generated in vitro could be assessed using histological analyses combined with immunohistochemical staining of keratinocyte differentiation markers. Computer-based analysis of scanned…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Dawid Zamojski , Agnieszka Gogler , Dorota Scieglinska , Michal Marczyk

The recent advancement of spatial transcriptomics (ST) allows to characterize spatial gene expression within tissue for discovery research. However, current ST platforms suffer from low resolution, hindering in-depth understanding of…

Image and Video Processing · Electrical Eng. & Systems 2025-11-05 Xiaofei Wang , Xingxu Huang , Stephen J. Price , Chao Li

Renal pathology, as the gold standard of kidney disease diagnosis, requires doctors to analyze a series of tissue slices stained by H&E staining and special staining like Masson, PASM, and PAS, respectively. These special staining methods…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Tao Ma , Chao Zhang , Min Lu , Lin Luo

We propose a two-step domain shift-invariant mitosis cell detection method based on Faster RCNN and a convolutional neural network (CNN). We generate various domain-shifted versions of existing histopathology images using a stain…

Computer Vision and Pattern Recognition · Computer Science 2021-09-29 Ramin Nateghi , Fattaneh Pourakpour
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