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Stepped-wedge cluster randomised trials (SW-CRTs) increasingly evaluate complex interventions, yet methodological guidance for analysing composite endpoints using generalized pairwise comparisons (GPC)remains limited. This work investigates…

Intercurrent events, such as treatment switching, rescue medication, dropout, or truncation by death, frequently complicate intention-to-treat analyses in randomized clinical trials. Existing causal inference frameworks typically target…

Methodology · Statistics 2026-03-12 Georgi Baklicharov , Kelly Van Lancker , Stijn Vansteelandt

Extracting meaningful drug-related information chunks, such as adverse drug events (ADE), is crucial for preventing morbidity and saving many lives. Most ADEs are reported via an unstructured conversation with the medical context, so…

Computation and Language · Computer Science 2023-08-16 Jie Yang , Soyeon Caren Han , Siqu Long , Josiah Poon , Goran Nenadic

Inspired by the recent success of deep learning in multiscale information encoding, we introduce a variational autoencoder (VAE) based semi-supervised method for detection of faulty traffic data, which is cast as a classification problem.…

Machine Learning · Computer Science 2022-12-29 Yongcan Huang , Jidong J. Yang

In clinical trials, multiple outcomes of different priorities commonly occur as the patient's response may not be adequately characterized by a single outcome. Win statistics are appealing summary measures for between-group difference at…

Methodology · Statistics 2025-06-04 Ying Cui , Bo Huang , Gaohong Dong , Ryuji Uozumi , Lu Tian

In recent decades, event studies have emerged as a central methodology in health and social research for evaluating the causal effects of staggered interventions. In this paper, we analyze event studies from experimental design principles…

Methodology · Statistics 2024-11-25 Zhu Shen , Ambarish Chattopadhyay , Yuzhou Lin , Jose R. Zubizarreta

Period-prevalent cohorts are often used for their cost-saving potential in epidemiological studies of survival outcomes. Under this design, prevalent patients allow for evaluations of long-term survival outcomes without the need for long…

Methodology · Statistics 2024-10-28 Nicholas Hartman

Single-cell technologies enable comprehensive profiling of diverse immune cell-types through the measurement of multiple genes or proteins per individual cell. In order to translate immune signatures assayed from blood or tissue into…

Machine Learning · Computer Science 2024-11-26 Chi-Jane Chen , Haidong Yi , Natalie Stanley

We address causal estimation in semi-competing risks settings, where a non-terminal event may be precluded by one or more terminal events. We define a principal-stratification causal estimand for treatment effects on the non-terminal event,…

Methodology · Statistics 2025-06-27 Karina Gelis-Cadena , Michael Daniels , Juned Siddique

Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and…

Methodology · Statistics 2025-05-09 Zhiwei Zhang , Ya Wang , Dong Xi

Cardiovascular diseases are major causes of mortality globally. They often co-occur and are interrelated, leading to partial-order relationships among their onset times. However, these onset times are subject to informative censoring due to…

Methodology · Statistics 2026-04-07 Tonghui Yu , Liming Xiang

Epidemiologic studies often evaluate the association between an exposure and an event risk. When time-varying, exposure updates usually occur at discrete visits although changes are in continuous time and survival models require values to…

Safety-critical planning in complex environments, particularly at urban intersections, remains a fundamental challenge for autonomous driving. Existing methods, whether rule-based or data-driven, frequently struggle to capture complex scene…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Kefei Tian , Yuansheng Lian , Kai Yang , Xiangdong Chen , Shen Li

Echocardiography interpretation requires integrating multi-view temporal evidence with quantitative measurements and guideline-grounded reasoning, yet existing foundation-model pipelines largely solve isolated subtasks and fail when tool…

Artificial Intelligence · Computer Science 2026-03-17 Moein Heidari , Ali Mehrabian , Mohammad Amin Roohi , Wenjin Chen , David J. Foran , Jasmine Grewal , Ilker Hacihaliloglu

This study presents QuanvNeXt, an end-to-end fully quanvolutional model for EEG-based depression diagnosis. QuanvNeXt incorporates a novel Cross Residual block, which reduces feature homogeneity and strengthens cross-feature relationships…

Machine Learning · Computer Science 2025-12-11 Nabil Anan Orka , Ehtashamul Haque , Maftahul Jannat , Md Abdul Awal , Mohammad Ali Moni

As alternatives to the time-to-first-event analysis of composite endpoints, the {\it net benefit} (NB) and the {\it win ratio} (WR) -- which assess treatment effects using prioritized component outcomes based on clinical importance -- have…

Methodology · Statistics 2020-11-24 Roland A. Matsouaka , Adrian Coles

Continuous-variable quantum key distribution (CV QKD) using optical coherent detectors is practically favorable due to its low implementation cost, flexibility of wavelength division multiplexing, and compatibility with standard coherent…

Quantum Physics · Physics 2025-08-05 Anran Jin , Xingjian Zhang , Liang Jiang , Richard V. Penty , Pei Zeng

Time-to-event semi-competing risk endpoints may be correlated when both events are occurring on the same individual. These events and the association between them may also be influenced by individual characteristics. In this paper, we…

Methodology · Statistics 2023-04-07 Yinghui Wei , Malgorzata Wojtys , Lexy Sorrell , Peter Rowe

Depth estimation plays a crucial role in 3D scene understanding and is extensively used in a wide range of vision tasks. Image-based methods struggle in challenging scenarios, while event cameras offer high dynamic range and temporal…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Luoxi Jing , Dianxi Shi , Zhe Liu , Songchang Jin , Chunping Qiu , Ziteng Qiao , Yuxian Li , Jianqiang Xia

We reformulate and reframe a series of increasingly complex parametric statistical topics into a framework of response-vs-covariate (Re-Co) dynamics that is described without any explicit functional structures. Then we resolve these topics'…

Methodology · Statistics 2022-10-12 Ting-Li Chen , Hsieh Fushing , Elizabeth P. Chou