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Designing high-performance system heuristics is a creative, iterative process requiring experts to form hypotheses and execute multi-step conceptual shifts. While Large Language Models (LLMs) show promise in automating this loop, they…

Artificial Intelligence · Computer Science 2026-03-24 Pantea Karimi , Kimia Noorbakhsh , Mohammad Alizadeh , Hari Balakrishnan

Large language model-based multi-agent systems have shown great abilities across various tasks due to the collaboration of expert agents, each focusing on a specific domain. However, the impact of clumsy or even malicious agents--those who…

Artificial Intelligence · Computer Science 2025-05-30 Jen-tse Huang , Jiaxu Zhou , Tailin Jin , Xuhui Zhou , Zixi Chen , Wenxuan Wang , Youliang Yuan , Michael R. Lyu , Maarten Sap

Current tool-using AI agents suffer from limited action space, context inefficiency, and probabilistic instability that makes them unsuitable for handling repetitive tasks which are otherwise reliably and efficiently tackled by agentic…

Software Engineering · Computer Science 2025-12-19 Nishant Gaurav , Adit Akarsh , Tejas Ravishankar , Manoj Bajaj

The application of Large Language Models (LLMs) in healthcare is expanding rapidly, with one potential use case being the translation of formal medical reports into patient-legible equivalents. Currently, LLM outputs often need to be edited…

Multiagent Systems · Computer Science 2024-08-06 Malavikha Sudarshan , Sophie Shih , Estella Yee , Alina Yang , John Zou , Cathy Chen , Quan Zhou , Leon Chen , Chinmay Singhal , George Shih

Proactive agents read user activity as text and call an LLM on every event to decide whether to act. But user activity is not natively text: it is a structured event stream of (actor, verb, object, timestamp) tuples that the operating…

Computation and Language · Computer Science 2026-05-29 Xiaoze Liu , Ruowang Zhang , Amir H. Abdi , Michel Galley , Zhikai Chen , Siheng Xiong , Xiaoqian Wang , Jing Gao

As multi-agent systems powered by Large Language Models (LLMs) are increasingly adopted in real-world workflows, users with diverse technical backgrounds are now building and refining their own agentic processes. However, these systems can…

Human-Computer Interaction · Computer Science 2026-03-05 Xinru Wang , Ming Yin , Eunyee Koh , Mustafa Doga Dogan

Modern clinical practice relies on evidence-based guidelines implemented as compact scoring systems composed of a small number of interpretable decision rules. While machine-learning models achieve strong performance, many fail to translate…

Machine Learning · Computer Science 2026-05-25 Silas Ruhrberg Estévez , Christopher Chiu , Mihaela van der Schaar

Existing LLM agent systems typically select actions from a fixed and predefined set at every step. While this approach is effective in closed, narrowly scoped environments, it presents two major challenges for real-world, open-ended…

The rapid advancement of large language model (LLM) agents has raised new concerns regarding their safety and security. In this paper, we propose GuardAgent, the first guardrail agent to protect target agents by dynamically checking whether…

Machine Learning · Computer Science 2025-05-30 Zhen Xiang , Linzhi Zheng , Yanjie Li , Junyuan Hong , Qinbin Li , Han Xie , Jiawei Zhang , Zidi Xiong , Chulin Xie , Carl Yang , Dawn Song , Bo Li

Large language model (LLM)-based agents are increasingly employed to interact with external environments (e.g., games, APIs, world models) to solve user-provided tasks. However, current frameworks often lack the ability to collaborate…

Computation and Language · Computer Science 2025-04-22 Vardhan Dongre , Xiaocheng Yang , Emre Can Acikgoz , Suvodip Dey , Gokhan Tur , Dilek Hakkani-Tür

Modern AI agents execute real-world side effects through tool calls such as file operations, shell commands, HTTP requests, and database queries. A single unsafe action, including accidental deletion, credential exposure, or data…

Artificial Intelligence · Computer Science 2026-05-07 Chenglin Yang

Autonomous agents powered by large language models (LLMs) enable novel use cases in domains where responsible action is increasingly important. Yet the inherent unpredictability of LLMs raises safety concerns about agent reliability. In…

Artificial Intelligence · Computer Science 2025-05-19 Jan Chojnacki

Many real-world systems, such as transportation systems, ecological systems, and Internet systems, are complex systems. As an important tool for studying complex systems, computational experiments can map them into artificial society models…

Multiagent Systems · Computer Science 2025-07-29 Ming Zhang , Yiling Xuan , Qun Ma , Yuwei Guo

Neuroscience data are highly fragmented across labs, formats, and experimental paradigms, and reuse often requires substantial manual effort. A persistent roadblock to data reuse and integration is the need to decipher bespoke and diverse…

Machine Learning · Computer Science 2026-05-15 Ling-Qi Zhang , Kristin Branson

Indirect prompt injection threatens LLM agents by embedding malicious instructions in external content, enabling unauthorized actions and data theft. LLM agents maintain working memory through their context window, which stores interaction…

Cryptography and Security · Computer Science 2026-02-10 Ruoyao Wen , Hao Li , Chaowei Xiao , Ning Zhang

LLM agents rely heavily on high-quality trajectory data to guide their problem-solving behaviors, yet producing such data requires substantial task design, high-capacity model generation, and manual filtering. Despite the high cost of…

Cryptography and Security · Computer Science 2026-05-05 Wenlong Meng , Chen Gong , Terry Yue Zhuo , Fan Zhang , Kecen Li , Zheng Liu , Zhou Yang , Chengkun Wei , Wenzhi Chen

Agentic frameworks powered by Large Language Models (LLMs) can be useful tools in scientific workflows by enabling human-AI co-creation. A key challenge is recommending the next steps during workflow creation without relying solely on LLMs,…

Current LLM agents operate under an implicit but universal assumption: execution is a transaction -- the user submits a request, the agent works in isolation, and only upon completion does the dialogue resume. This forces users into a…

Machine Learning · Computer Science 2026-04-28 Zhiyuan Zhai , Ming Li , Xin Wang

What if a browser agent could learn your work simply by watching you do it? We present cotomi Act, a browser-based computer-using agent that combines reliable multi-step task execution with persistent organizational knowledge learned from…

Artificial Intelligence · Computer Science 2026-05-06 Masafumi Oyamada , Kunihiro Takeoka , Kosuke Akimoto , Ryoma Obara , Masafumi Enomoto , Haochen Zhang , Daichi Haraguchi , Takuya Tamura

Background: There is great interest in agentic LLMs, large language models that act as agents. Objectives: We review the growing body of work in this area and provide a research agenda. Methods: Agentic LLMs are LLMs that (1) reason, (2)…

Artificial Intelligence · Computer Science 2026-01-01 Aske Plaat , Max van Duijn , Niki van Stein , Mike Preuss , Peter van der Putten , Kees Joost Batenburg