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This study presents an innovative method for Alzheimer's disease diagnosis using 3D MRI designed to enhance the explainability of model decisions. Our approach adopts a soft attention mechanism, enabling 2D CNNs to extract volumetric…
We present a flexible Bayesian semiparametric mixed model for longitudinal data analysis in the presence of potentially high-dimensional categorical covariates. Building on a novel hidden Markov tensor decomposition technique, our proposed…
Alzheimer's disease (AD) is a progressive neurological disorder, meaning that the symptoms develop gradually throughout the years. It is also the main cause of dementia, which affects memory, thinking skills, and mental abilities. Nowadays,…
INTRODUCTION: Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer Disease (AD) heterogeneity. We employed a deep learning-based multimodal normative framework to analyze…
Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…
Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…
Recent technology and equipment advancements provide with us opportunities to better analyze Alzheimer's disease (AD), where we could collect and employ the data from different image and genetic modalities that may potentially enhance the…
Accurate diagnosis and prognosis of Alzheimer's disease are crucial to develop new therapies and reduce the associated costs. Recently, with the advances of convolutional neural networks, methods have been proposed to automate these two…
Predicting conversion from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) is critical for early intervention. Current deep learning paradigms predominantly rely on cross-sectional structural MRI, neglecting prognostic value in…
Accurately discriminating progressive stages of Alzheimer's Disease (AD) is crucial for early diagnosis and prevention. It often involves multiple imaging modalities to understand the complex pathology of AD, however, acquiring a complete…
Motivated by recent data analyses in biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose using flexible multivariate splines over triangulations to…
Recent medical imaging studies have given rise to distinct but inter-related datasets corresponding to multiple experimental tasks or longitudinal visits. Standard scalar-on-image regression models that fit each dataset separately are not…
Progressive neurodegenerative diseases, including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), exhibit complex, nonlinear trajectories that challenge deterministic…
Aiming at abundant scientific and engineering data with not only high dimensionality but also complex structure, we study the regression problem with a multidimensional array (tensor) response and a vector predictor. Applications include,…
We propose a versatile framework for survival analysis that combines advanced concepts from statistics with deep learning. The presented framework is based on piecewise exponential models and thereby supports various survival tasks, such as…
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that progressively impairs memory, decision-making, and overall cognitive function. As AD is irreversible, early prediction is critical for timely intervention and…
To achieve effective and efficient detection of Alzheimer's disease (AD), many machine learning methods have been introduced into this realm. However, the general case of limited training samples, as well as different feature…
With the increasing amounts of high-dimensional heterogeneous data to be processed, multi-modality feature selection has become an important research direction in medical image analysis. Traditional methods usually depict the data structure…
Generative approaches for cross-modality transformation have recently gained significant attention in neuroimaging. While most previous work has focused on case-control data, the application of generative models to disorder-specific…
Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in Alzheimer's disease (AD). Traditional survival models often…