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A semiparametric copula-based two-part quantile regression framework is developed for the analysis of semicontinuous outcomes characterized by a point mass at zero and a continuous positive component. The proposed approach models the…

Methodology · Statistics 2026-03-17 Guanjie Lyu , Mohamed Belalia , Abdulkadir Hussein

With the wide application of electronic health records (EHR) in healthcare facilities, health event prediction with deep learning has gained more and more attention. A common feature of EHR data used for deep-learning-based predictions is…

Machine Learning · Computer Science 2021-12-17 Chang Lu , Tian Han , Yue Ning

Studying physiology over a broad population for long periods of time is difficult primarily because collecting human physiologic data is intrusive, dangerous, and expensive. Electronic health record (EHR) data promise to support the…

Quantitative Methods · Quantitative Biology 2015-05-30 DJ Albers , George Hripcsak , Michael Schmidt

In this paper, we concentrate on new methodologies for copulas introduced and developed by Joe, Cooke, Bedford, Kurowica, Daneshkhah and others on the new class of graphical models called vines as a way of constructing higher dimensional…

Computation · Statistics 2012-10-30 Alireza Daneshkhah , Golamali Parham , Omid Chatrabgoun , M. Jokar

This study presents a fully automated methodology for early prediction studies in clinical settings, leveraging information extracted from unstructured discharge reports. The proposed pipeline uses discharge reports to support the three…

Predicting disease trajectories from electronic health records (EHRs) is a complex task due to major challenges such as data non-stationarity, high granularity of medical codes, and integration of multimodal data. EHRs contain both…

Machine Learning · Computer Science 2025-02-26 Sifal Klioui , Sana Sellami , Youssef Trardi

While the volume of electronic health records (EHR) data continues to grow, it remains rare for hospital systems to capture dense physiological data streams, even in the data-rich intensive care unit setting. Instead, typical EHR records…

Machine Learning · Computer Science 2018-12-04 Satya Narayan Shukla , Benjamin M. Marlin

In the multiple testing context, we utilize vine copulae for optimizing the effective number of tests. It is well known that for the calibration of multiple tests (for control of the family-wise error rate) the dependencies between the…

Methodology · Statistics 2020-02-25 Nico Steffen , Thorsten Dickhaus

In this paper, we revisit the notion of partial copula, originally introduced to test conditional independence, highlighting its capability to represent the dependence between two random variables after removing their dependence with a…

Methodology · Statistics 2026-05-26 Vinícius Litvinoff Justus , Felipe Fontana Vieira

This paper considers the problem of invoking auxiliary, unobservable variables to facilitate the structuring of causal tree models for a given set of continuous variables. Paralleling the treatment of bi-valued variables in [Pearl 1986], we…

Artificial Intelligence · Computer Science 2013-04-11 Lei Xu , Judea Pearl

Joint multivariate longitudinal and time-to-event data are gaining increasing attention in the biomedical sciences where subjects are followed over time to monitor the progress of a disease or medical condition. In the insurance context,…

Methodology · Statistics 2019-02-12 Edward W. Frees , Catalina Bolancé , Montserrat Guillen , Emiliano Valdez

Copula models are flexible tools to represent complex structures of dependence for multivariate random variables. According to Sklar's theorem (Sklar, 1959), any d-dimensional absolutely continuous density can be uniquely represented as the…

Methodology · Statistics 2021-03-05 Clara Grazian , Luciana Dalla Valle , Brunero Liseo

Deep generative models offer powerful tools for multivariate data analysis, but their black-box architectures are often unidentified and difficult to interpret. We introduce the Deep Discrete Encoder (DDE) Copula, an identifiable and…

Machine Learning · Statistics 2026-05-28 Joseph Feldman , Yuqi Gu

Electronic health records (EHRs) contain important longitudinal information on individuals who have received medical care. Traditionally, EHRs have been used to support a wide range of administrative activities such as billing and clinical…

Databases · Computer Science 2024-11-18 Arian Aminoleslami , Geoffrey M. Anderson , Davide Chicco

This study proposes a risk prediction method based on a Multi-Scale Temporal Alignment Network (MSTAN) to address the challenges of temporal irregularity, sampling interval differences, and multi-scale dynamic dependencies in Electronic…

Machine Learning · Computer Science 2025-11-27 Wei-Chen Chang , Lu Dai , Ting Xu

Integrative analysis of datasets generated by multiple cohorts is a widely-used approach for increasing sample size, precision of population estimators, and generalizability of analysis results in epidemiological studies. However, often…

In this paper, we present a variable ranking approach established on a novel measure to select important variables in bivariate Copula Link-Based Additive Models (Marra & Radice, 2020). The proposal allows for identifying two sets of…

Methodology · Statistics 2024-10-14 Danilo Petti , Marcella Niglio , Marialuisa Restaino

A novel copula-based multivariate panel ordinal model is developed to estimate structural relations among components of well-being. Each ordinal time-series is modelled using a copula-based Markov model to relate the marginal distributions…

Methodology · Statistics 2017-06-02 Aristidis K. Nikoloulopoulos , Emmanouil Mentzakis

The time-varying Vine Copula model has become a new direction in the Vine Copula class of models due to its time-varying structural parameters. We have observed that the Vine structures of the time-varying Vine Copula model currently used…

Applications · Statistics 2025-09-16 XueZeng Yu

The study of dependence between random variables is the core of theoretical and applied statistics. Static and dynamic copula models are useful for describing the dependence structure, which is fully encrypted in the copula probability…

Methodology · Statistics 2018-03-20 Dominque Guégan , Matteo Iacopini