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Large Language Models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation, enabling their widespread adoption across various domains. However, their susceptibility to prompt injection attacks…

Cryptography and Security · Computer Science 2025-05-05 Jinsheng Pan , Xiaogeng Liu , Chaowei Xiao

The challenge of designing effective reward functions in reinforcement learning (RL) represents a significant bottleneck, often requiring extensive human expertise and being time-consuming. Previous work and recent advancements in large…

Machine Learning · Computer Science 2025-11-25 Franklin Cardenoso , Wouter Caarls

Embodied agents operating in household environments must interpret ambiguous and under-specified human instructions. A capable household robot should recognize ambiguity and ask relevant clarification questions to infer the user intent…

Artificial Intelligence · Computer Science 2025-10-06 Ram Ramrakhya , Matthew Chang , Xavier Puig , Ruta Desai , Zsolt Kira , Roozbeh Mottaghi

In recent years, deep learning has made remarkable strides, surpassing human capabilities in tasks like strategy games, and it has found applications in complex domains, including protein folding. In the realm of quantum chemistry, machine…

Chemical Physics · Physics 2024-01-09 Rhyan Barrett , Julia Westermayr

Search agents powered by Large Language Models (LLMs) have demonstrated significant potential in tackling knowledge-intensive tasks. Reinforcement learning (RL) has emerged as a powerful paradigm for training these agents to perform…

Computation and Language · Computer Science 2026-05-11 Shiyu Li , Yang Tang , Yifan Wang , Peiming Li , Xi Chen

Applying Reinforcement learning (RL) following maximum likelihood estimation (MLE) pre-training is a versatile method for enhancing neural machine translation (NMT) performance. However, recent work has argued that the gains produced by RL…

Computation and Language · Computer Science 2022-10-07 Asaf Yehudai , Leshem Choshen , Lior Fox , Omri Abend

Reinforcement learning (RL) over text representations can be effective for finding high-value policies that can search over graphs. However, RL requires careful structuring of the search space and algorithm design to be effective in this…

Machine Learning · Computer Science 2023-10-05 Raj Ghugare , Santiago Miret , Adriana Hugessen , Mariano Phielipp , Glen Berseth

Molecular optimization is a central task in drug discovery that requires precise structural reasoning and domain knowledge. While large language models (LLMs) have shown promise in generating high-level editing intentions in natural…

Machine Learning · Computer Science 2025-10-17 Wenyu Zhu , Chengzhu Li , Xiaohe Tian , Yifan Wang , Yinjun Jia , Jianhui Wang , Bowen Gao , Ya-Qin Zhang , Wei-Ying Ma , Yanyan Lan

Computational drug discovery, particularly the complex workflows of drug molecule screening and optimization, requires orchestrating dozens of specialized tools in multi-step workflows, yet current AI agents struggle to maintain robust…

Large language models (LLMs) show promise for molecular optimization, but aligning them with selective and competing drug-design constraints remains challenging. We propose C-Moral, a reinforcement learning post-training framework for…

Machine Learning · Computer Science 2026-05-28 Rui Gao , Youngseung Jeon , Swastik Roy , Morteza Ziyadi , Xiang 'Anthony' Chen

LLMs demonstrate surface-level fluency in code generation but struggle with structured reasoning tasks requiring correctness and semantic alignment. While Chain-of-Thought (CoT) prompting enhances reasoning through intermediate steps, it…

Software Engineering · Computer Science 2025-10-01 Xunzhu Tang , Iyiola Emmanuel Olatunji , Tiezhu Sun , Jacques Klein , Tegawende F. Bissyande

Multi-agent systems (MAS) and reinforcement learning (RL) are widely used to enhance the agentic capabilities of large language models (LLMs). MAS improves task performance through role-based orchestration, while RL uses environmental…

Machine Learning · Computer Science 2026-02-02 Yujie Zhao , Lanxiang Hu , Yang Wang , Minmin Hou , Hao Zhang , Ke Ding , Jishen Zhao

CO2 reduction requires efficient catalysts, yet materials discovery remains bottlenecked by 10-20 year development cycles requiring deep domain expertise. This paper demonstrates how large language models can assist the catalyst discovery…

Materials Science · Physics 2026-03-18 AI Scientists , Xinyi Lin , Danqing Yin , Ying Guo

In recommendation systems, diversity and novelty are essential for capturing varied user preferences and encouraging exploration, yet many systems prioritize click relevance. While reinforcement learning (RL) has been explored to improve…

Machine Learning · Computer Science 2025-07-30 Jiin Woo , Alireza Bagheri Garakani , Tianchen Zhou , Zhishen Huang , Yan Gao

Emerging reasoning models hold promise for automating scientific discovery. However, their training is hindered by a critical supervision gap: experimental outcomes are abundant, whereas intermediate reasoning steps are rarely documented at…

Biomolecules · Quantitative Biology 2026-03-24 Zequn Liu , Kehan Wu , Shufang Xie , Zekun Guo , Wei Zhang , Tao Qin , Renhe Liu , Yingce Xia

Machine learning has the potential to automate molecular design and drastically accelerate the discovery of new functional compounds. Towards this goal, generative models and reinforcement learning (RL) using string and graph…

Machine Learning · Computer Science 2022-02-02 Daniel Flam-Shepherd , Alexander Zhigalin , Alán Aspuru-Guzik

Large Language Models (LLMs) have demonstrated remarkable capabilities in reasoning and tool use. However, the fundamental cognitive faculties essential for problem solving, including perception, reasoning, and memory, remain the stable…

Artificial Intelligence · Computer Science 2026-05-12 Xiaozhe Li , Jixuan Chen , Xinyu Fang , Shengyuan Ding , Haodong Duan , Qingwen Liu , Kai Chen

Effective training-time guidance is central to multi-agent reinforcement learning (MARL), yet remains difficult in sparse-reward settings where weak supervision limits coordination and policy improvement, and existing methods often require…

Multiagent Systems · Computer Science 2026-05-29 Xiaoguang Wu , Zhi Zheng , Hui Xiong

Multi-agent systems of large language models (LLMs) show promise for complex reasoning, but their effectiveness is often limited by fixed collaboration protocols. These frameworks typically focus on macro-level orchestration while…

Artificial Intelligence · Computer Science 2025-12-10 Wei Yang , Jesse Thomason

Deep Research agents tackle knowledge-intensive tasks through multi-round retrieval and decision-oriented generation. While reinforcement learning (RL) has been shown to improve performance in this paradigm, its contributions remain…

Computation and Language · Computer Science 2026-02-24 Yinuo Xu , Shuo Lu , Jianjie Cheng , Meng Wang , Qianlong Xie , Xingxing Wang , Ran He , Jian Liang
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