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Most protein families have fewer than 100 known members, a regime where deep generative models overfit or collapse. We propose stochastic attention (SA), a training-free sampler that treats the modern Hopfield energy over a protein…

Machine Learning · Computer Science 2026-03-17 Jeffrey D. Varner

Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

Access to electronic health records (EHRs) for digital health research is often limited by privacy regulations and institutional barriers. Synthetic EHRs have been proposed as a way to enable safe and sovereign data sharing; however,…

Machine Learning · Computer Science 2026-03-10 Guanglin Zhou , Armin Catic , Motahare Shabestari , Matthew Young , Chaiquan Li , Katrina Poppe , Sebastiano Barbieri

Synthetic data generation plays a crucial role in medical research by mitigating privacy concerns and enabling large-scale patient data analysis. This study presents a beta-Variational Autoencoder Graph Convolutional Neural Network…

Machine Learning · Computer Science 2025-06-18 Francesco Fabbri , Martino Andrea Scarpolini , Angelo Iollo , Francesco Viola , Francesco Tudisco

Access to individual-level health data is essential for gaining new insights and advancing science. In particular, modern methods based on artificial intelligence rely on the availability of and access to large datasets. In the health…

Healthcare research and development face significant obstacles due to data scarcity and stringent privacy regulations, such as HIPAA and the GDPR, restricting access to essential real-world medical data. These limitations impede innovation,…

Machine Learning · Computer Science 2025-10-17 Md Ibrahim Shikder Mahin , Md Shamsul Arefin , Md Tanvir Hasan

Sensitive medical data is often subject to strict usage constraints. In this paper, we trained a generative adversarial network (GAN) on real-world electronic health records (EHR). It was then used to create a data-set of "fake" patients…

Machine Learning · Computer Science 2021-09-07 John Weldon , Tomas Ward , Eoin Brophy

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

Background: Heart failure (HF) research is constrained by limited access to large, shareable datasets due to privacy regulations and institutional barriers. Synthetic data generation offers a promising solution to overcome these challenges…

The widespread adoption of electronic health records and digital healthcare data has created a demand for data-driven insights to enhance patient outcomes, diagnostics, and treatments. However, using real patient data presents privacy and…

Machine Learning · Computer Science 2023-11-15 Aryan Jadon , Shashank Kumar

The rapid growth in data availability has facilitated research and development, yet not all industries have benefited equally due to legal and privacy constraints. The healthcare sector faces significant challenges in utilizing patient data…

Methodology · Statistics 2025-11-18 Katariina Perkonoja , Kari Auranen , Joni Virta

Generating datasets that "look like" given real ones is an interesting tasks for healthcare applications of ML and many other fields of science and engineering. In this paper we propose a new method of general application to binary datasets…

Machine Learning · Statistics 2018-07-05 Laura Aviñó , Matteo Ruffini , Ricard Gavaldà

Generating high-resolution 3D shapes using volumetric representations such as Signed Distance Functions (SDFs) presents substantial computational and memory challenges. We introduce Direct3D-S2, a scalable 3D generation framework based on…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Shuang Wu , Youtian Lin , Feihu Zhang , Yifei Zeng , Yikang Yang , Yajie Bao , Jiachen Qian , Siyu Zhu , Xun Cao , Philip Torr , Yao Yao

Class imbalance can often degrade predictive performance of supervised learning algorithms. Balanced classes can be obtained by oversampling exact copies, with noise, or interpolation between nearest neighbours (as in traditional SMOTE…

Machine Learning · Computer Science 2022-01-17 Emily Muller , Xu Zheng , Jer Hayes

Artificial Intelligence in healthcare is a new and exciting frontier and the possibilities are endless. With deep learning approaches beating human performances in many areas, the logical next step is to attempt their application in the…

Machine Learning · Computer Science 2018-08-21 Ally Salim

Despite significant recent progress in the area of Brain-Computer Interface (BCI), there are numerous shortcomings associated with collecting Electroencephalography (EEG) signals in real-world environments. These include, but are not…

Quantitative Methods · Quantitative Biology 2019-10-14 Nik Khadijah Nik Aznan , Amir Atapour-Abarghouei , Stephen Bonner , Jason Connolly , Noura Al Moubayed , Toby Breckon

The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across…

Machine Learning · Computer Science 2023-02-01 Jin Li , Benjamin J. Cairns , Jingsong Li , Tingting Zhu

We propose a deep generative approach using latent temporal processes for modeling and holistically analyzing complex disease trajectories, with a particular focus on Systemic Sclerosis (SSc). We aim to learn temporal latent representations…

Accurate and comprehensive clinical documentation is crucial for delivering high-quality healthcare, facilitating effective communication among providers, and ensuring compliance with regulatory requirements. However, manual transcription…

Computation and Language · Computer Science 2024-06-12 Anjanava Biswas , Wrick Talukdar

Problem: Effective patient-centered communication is a core competency for physicians. However, both seasoned providers and medical trainees report decreased confidence in leading conversations on sensitive topics such as goals of care or…

Human-Computer Interaction · Computer Science 2024-05-31 Simon N. Chu , Alex J. Goodell
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