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Objective: Large Language Models (LLMs) demonstrate significant capabilities in medical text understanding and generation. However, their diagnostic reliability in complex clinical scenarios remains limited. This study aims to enhance LLMs'…

Computation and Language · Computer Science 2025-08-04 Peixian Li , Yu Tian , Ruiqi Tu , Chengkai Wu , Jingjing Ren , Jingsong Li

Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields. While Retrieval-Augmented Generation…

Computation and Language · Computer Science 2026-03-25 Wenhao Wu , Zhentao Tang , Yafu Li , Shixiong Kai , Mingxuan Yuan , Chunlin Chen , Zhi Wang

Inspired by the dual-process theory of human cognition from \textit{Thinking, Fast and Slow}, we introduce \textbf{PRIME} (Planning and Retrieval-Integrated Memory for Enhanced Reasoning), a multi-agent reasoning framework that dynamically…

Artificial Intelligence · Computer Science 2025-11-12 Hieu Tran , Zonghai Yao , Nguyen Luong Tran , Zhichao Yang , Feiyun Ouyang , Shuo Han , Razieh Rahimi , Hong Yu

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

Large language models (LLMs) have emerged as effective action policies for sequential decision-making (SDM) tasks due to their extensive prior knowledge. However, this broad yet general knowledge is often insufficient for specific…

Machine Learning · Computer Science 2025-10-01 Xue Yan , Zijing Ou , Mengyue Yang , Yan Song , Haifeng Zhang , Yingzhen Li , Jun Wang

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Tool-augmented large language model (LLM) agents can orchestrate specialist classifiers, segmentation models, and visual question-answering modules to interpret chest X-rays. However, these agents still solve each case in isolation: they…

Artificial Intelligence · Computer Science 2026-04-17 Weixiang Shen , Bailiang Jian , Jun Li , Che Liu , Johannes Moll , Xiaobin Hu , Daniel Rueckert , Hongwei Bran Li , Jiazhen Pan

In contemporary software development, the widespread use of indirect calls to achieve dynamic features poses challenges in constructing precise control flow graphs (CFGs), which further impacts the performance of downstream static analysis…

Software Engineering · Computer Science 2024-11-01 Baijun Cheng , Cen Zhang , Kailong Wang , Ling Shi , Yang Liu , Haoyu Wang , Yao Guo , Ding Li , Xiangqun Chen

Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool…

Reasoning-augmented search agents, such as Search-R1, are trained to reason, search, and generate the final answer iteratively. Nevertheless, due to their limited capabilities in reasoning and search, their performance on multi-hop QA…

Computation and Language · Computer Science 2025-10-14 Shu Zhao , Tan Yu , Anbang Xu

Stereotactic radiosurgery (SRS) demands precise dose shaping around critical structures, yet black-box AI systems have limited clinical adoption due to opacity concerns. We tested whether chain-of-thought reasoning improves agentic planning…

This paper introduces SePA (Search-enhanced Predictive AI Agent), a novel LLM health coaching system that integrates personalized machine learning and retrieval-augmented generation to deliver adaptive, evidence-based guidance. SePA…

Human-Computer Interaction · Computer Science 2025-09-08 Melik Ozolcer , Sang Won Bae

Large language models (LLMs) have recently shown strong progress on scientific reasoning, yet two major bottlenecks remain. First, explicit retrieval fragments reasoning, imposing a hidden "tool tax" of extra tokens and steps. Second,…

Recent advancements in Multimodal Large Language Models (MLLMs) pursue omni-perception capabilities, yet integrating robust sensory grounding with complex reasoning remains a challenge, particularly for underrepresented regions. In this…

Large language model (LLM) agents have evolved to intelligently process information, make decisions, and interact with users or tools. A key capability is the integration of long-term memory capabilities, enabling these agents to draw upon…

Computation and Language · Computer Science 2025-08-04 Rana Salama , Jason Cai , Michelle Yuan , Anna Currey , Monica Sunkara , Yi Zhang , Yassine Benajiba

Reinforcement learning (RL) with outcome-based rewards has achieved significant success in training large language model (LLM) agents for complex reasoning tasks. However, in active reasoning where agents need to strategically ask questions…

Artificial Intelligence · Computer Science 2026-03-13 Deyu Zou , Yongqiang Chen , Fan Feng , Mufei Li , Pan Li , Yu Gong , James Cheng

A surge in academic publications calls for automated deep research (DR) systems, but accurately evaluating them is still an open problem. First, existing benchmarks often focus narrowly on retrieval while neglecting high-level planning and…

Computation and Language · Computer Science 2026-02-02 Zhihan Guo , Feiyang Xu , Yifan Li , Muzhi Li , Shuai Zou , Jiele Wu , Han Shi , Haoli Bai , Ho-fung Leung , Irwin King

Clinical diagnosis prediction models, when provided with a patient's medical history, aim to detect potential diseases early, facilitating timely intervention and improving prognostic outcomes. However, the inherent scarcity of patient data…

Computation and Language · Computer Science 2025-01-30 Mingyu Derek Ma , Xiaoxuan Wang , Yijia Xiao , Anthony Cuturrufo , Vijay S Nori , Eran Halperin , Wei Wang

Deep neural networks suffer from the catastrophic forgetting problem in the field of continual learning (CL). To address this challenge, we propose MGSER-SAM, a novel memory replay-based algorithm specifically engineered to enhance the…

Machine Learning · Computer Science 2024-05-16 Xingyu Li , Bo Tang

Achieving self-evolution in intelligent agents requires the continual accumulation of new knowledge across changing task sequences without forgetting previously acquired abilities. Existing approaches either internalize knowledge by…

Machine Learning · Computer Science 2026-05-22 Dianzhi Yu , Vireo Zhang , Hongru Wang , Yanyu Chen , Minda Hu , Wanghan Xu , Siki Chen , Philip Torr , Zhenfei Yin , Irwin King