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Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

Reasoning benchmarks have played a crucial role in the progress of language models. Yet rigorous evaluation remains a significant challenge as static question-answer pairs provide only a snapshot of performance, compressing complex behavior…

Computation and Language · Computer Science 2026-01-21 Sergio Servantez , Sarah B. Lawsky , Rajiv Jain , Daniel W. Linna , Kristian Hammond

Neuro-Symbolic AI (NeSy) holds promise to ensure the safe deployment of AI systems, as interpretable symbolic techniques provide formal behaviour guarantees. The challenge is how to effectively integrate neural and symbolic computation, to…

Artificial Intelligence · Computer Science 2024-02-06 Daniel Cunnington , Mark Law , Jorge Lobo , Alessandra Russo

This study investigates clinicians' perceptions and attitudes toward an assistive artificial intelligence (AI) system that employs a speech-based explainable ML algorithm for detecting depression. The AI system detects depression from…

Human-Computer Interaction · Computer Science 2024-10-25 Kexin Feng , Theodora Chaspari

Medical vision-language models (VLMs) show strong performance on radiology tasks but often produce fluent yet weakly grounded conclusions due to over-reliance on a dominant modality. We introduce a context-aligned reasoning framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Sumra Khan , Sagar Chhabriya , Aizan Zafar , Sheeraz Arif , Amgad Muneer , Anas Zafar , Shaina Raza , Rizwan Qureshi

We introduce PRISM (Predictive Reasoning in Sequential Medicine), a transformer-based architecture designed to model the sequential progression of clinical decision-making processes. Unlike traditional approaches that rely on isolated…

Computation and Language · Computer Science 2025-06-16 Lionel Levine , John Santerre , Alex S. Young , T. Barry Levine , Francis Campion , Majid Sarrafzadeh

Neurosymbolic artificial intelligence (AI) systems combine neural network and classical symbolic AI mechanisms to exploit the complementary strengths of large scale, generalizable learning and robust, verifiable reasoning. Numerous…

Artificial Intelligence · Computer Science 2025-07-15 Aniruddha Chattopadhyay , Raj Dandekar , Kaushik Roy

Multimodal large language models (MLLMs) that integrate visual and textual reasoning leverage chain-of-thought (CoT) prompting to tackle complex visual tasks, yet continue to exhibit visual hallucinations and an over-reliance on textual…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Jing Bi , Guangyu Sun , Ali Vosoughi , Chen Chen , Chenliang Xu

Structured tables are essential for conveying high-density information in professional domains such as finance, healthcare, and scientific research. Despite the progress in Multimodal Large Language Models (MLLMs), reasoning performance…

Artificial Intelligence · Computer Science 2026-04-07 Xiaoyu Chen , Lu Dai , Hanqing Wang , Zhuoyu Li , Wenbin Dai , Yanzong Zheng , Zhenggang Xia , Junyong Lin , Hui Xiong

Background: The rapid integration of foundation models into clinical practice and public health necessitates a rigorous evaluation of their true clinical reasoning capabilities beyond narrow examination success. Current benchmarks,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Dingyu Wang , Zimu Yuan , Jiajun Liu , Shanggui Liu , Nan Zhou , Tianxing Xu , Di Huang , Dong Jiang

The emergence of large language models has enabled sophisticated multi-agent systems, yet coordinating their reasoning capabilities through prompt engineering remains challenging. We present a theoretically-grounded framework for dynamic…

Multiagent Systems · Computer Science 2025-10-02 Hassen Dhrif

The integration of Artificial Intelligence in the development of computer systems presents a new challenge: make intelligent systems explainable to humans. This is especially vital in the field of health and well-being, where transparency…

Recent advancements in large language models (LLMs) have led to remarkable performance across a wide range of language understanding and mathematical tasks. As a result, increasing attention has been given to assessing the true reasoning…

Computation and Language · Computer Science 2025-03-14 Jonas Golde , Patrick Haller , Fabio Barth , Alan Akbik

Large Language Models (LLMs) demonstrate impressive capabilities in natural language processing but suffer from inaccuracies and logical inconsistencies known as hallucinations. This compromises their reliability, especially in domains…

Artificial Intelligence · Computer Science 2025-12-08 Ruslan Idelfonso Magana Vsevolodovna , Marco Monti

Effectiveness and interpretability are two essential properties for trustworthy AI systems. Most recent studies in visual reasoning are dedicated to improving the accuracy of predicted answers, and less attention is paid to explaining the…

Computer Vision and Pattern Recognition · Computer Science 2022-03-14 Shi Chen , Qi Zhao

Depression is a growing concern gaining attention in both public discourse and AI research. While deep neural networks (DNNs) have been used for recognition, they still lack real-world effectiveness. Large language models (LLMs) show strong…

Human-Computer Interaction · Computer Science 2025-08-27 Yupei Li , Shuaijie Shao , Manuel Milling , Björn W. Schuller

The application of Artificial Intelligence (AI) in healthcare has been revolutionary, especially with the recent advancements in transformer-based Large Language Models (LLMs). However, the task of understanding unstructured electronic…

Computation and Language · Computer Science 2023-08-08 Shivani Shekhar , Simran Tiwari , T. C. Rensink , Ramy Eskander , Wael Salloum

Dermatological care via telemedicine often lacks the rich context of in-person visits. Clinicians must make diagnoses based on a handful of images and brief descriptions, without the benefit of physical exams, second opinions, or reference…

Artificial Intelligence · Computer Science 2025-08-27 Karishma Thakrar , Shreyas Basavatia , Akshay Daftardar

This paper offers a systematic method for creating medical knowledge-grounded patient records for use in activities involving differential diagnosis. Additionally, an assessment of machine learning models that can differentiate between…

Machine Learning · Computer Science 2024-01-26 Zaid Al-Ars , Obinna Agba , Zhuoran Guo , Christiaan Boerkamp , Ziyaad Jaber , Tareq Jaber

The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific…

Computation and Language · Computer Science 2025-03-11 Luyi Jiang , Jiayuan Chen , Lu Lu , Xinwei Peng , Lihao Liu , Junjun He , Jie Xu