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AI tools in pathology have improved screening throughput, standardized quantification, and revealed prognostic patterns that inform treatment. However, adoption remains limited because most systems still lack the human-readable reasoning…

Artificial Intelligence · Computer Science 2025-11-18 Yunqi Hong , Johnson Kao , Liam Edwards , Nein-Tzu Liu , Chung-Yen Huang , Alex Oliveira-Kowaleski , Cho-Jui Hsieh , Neil Y. C. Lin

Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to…

Computation and Language · Computer Science 2026-04-28 Yimin Deng , Zhenxi Lin , Yejing Wang , Guoshuai Zhao , Pengyue Jia , Zichuan Fu , Derong Xu , Yefeng Zheng , Xiangyu Zhao , Li Zhu , Xian Wu , Xueming Qian

Large Language Models (LLMs) have revolutionized natural language processing, yet they struggle with inconsistent reasoning, particularly in novel domains and complex logical sequences. This research introduces Proof of Thought, a framework…

Artificial Intelligence · Computer Science 2024-10-24 Debargha Ganguly , Srinivasan Iyengar , Vipin Chaudhary , Shivkumar Kalyanaraman

When building artificial intelligence systems that can reason and answer questions about visual data, we need diagnostic tests to analyze our progress and discover shortcomings. Existing benchmarks for visual question answering can help,…

Computer Vision and Pattern Recognition · Computer Science 2016-12-22 Justin Johnson , Bharath Hariharan , Laurens van der Maaten , Li Fei-Fei , C. Lawrence Zitnick , Ross Girshick

Speech and language technologies offer valuable opportunities for supporting mental health assessment through objective and interpretable cues. We present a systematic feature-based analysis framework leveraging perceptually grounded…

Artificial Intelligence · Computer Science 2026-05-28 Vassilis Lyberatos , Edmund G. Dervakos , Eleni Adamidi , Athanasios Voulodimos , Giorgos Stamou

Recent advances in vision-language models (VLMs) have achieved remarkable performance on standard medical benchmarks, yet their true clinical reasoning ability remains unclear. Existing datasets predominantly emphasize classification…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Miao Jing , Mengting Jia , Junling Lin , Zhongxia Shen , Huan Gao , Mingkun Xu , Shangyang Li

Neuro-symbolic AI systems integrate neural perception with symbolic reasoning to enable data-efficient, interpretable, and robust intelligence beyond purely neural models. Although this compositional paradigm has shown superior performance…

Artificial Intelligence · Computer Science 2026-01-29 Zishen Wan , Che-Kai Liu , Jiayi Qian , Hanchen Yang , Arijit Raychowdhury , Tushar Krishna

The recent boom of large language models (LLMs) has re-ignited the hope that artificial intelligence (AI) systems could aid medical diagnosis. Yet despite dazzling benchmark scores, LLM assistants have yet to deliver measurable improvements…

Artificial Intelligence · Computer Science 2025-07-03 Matthew JY Kang , Wenli Yang , Monica R Roberts , Byeong Ho Kang , Charles B Malpas

Medical artificial intelligence (AI) systems frequently lack systematic domain expertise integration, potentially compromising diagnostic reliability. This study presents an ontology-based framework for bone disease diagnosis, developed in…

Artificial Intelligence · Computer Science 2025-06-06 Loan Dao , Ngoc Quoc Ly

Large language models (LLMs) offer transformative potential for clinical decision support in spine surgery but pose significant risks through hallucinations, which are factually inconsistent or contextually misaligned outputs that may…

Machine Learning · Computer Science 2025-11-21 Dong Chen , Yanzhe Wei , Zonglin He , Guan-Ming Kuang , Canhua Ye , Meiru An , Huili Peng , Yong Hu , Huiren Tao , Kenneth MC Cheung

The differential diagnosis of neurodegenerative dementias is a challenging clinical task, mainly because of the overlap in symptom presentation and the similarity of patterns observed in structural neuroimaging. To improve diagnostic…

Machine Learning · Computer Science 2025-05-27 Andrew Zamai , Nathanael Fijalkow , Boris Mansencal , Laurent Simon , Eloi Navet , Pierrick Coupe

Large Language Models (LLMs) excel in complex reasoning tasks but struggle with consistent rule application, exception handling, and explainability, particularly in domains like legal analysis that require both natural language…

Artificial Intelligence · Computer Science 2025-11-11 Albert Sadowski , Jarosław A. Chudziak

Human-in-the-loop validation is essential in safety-critical clinical AI, yet the transition between initial model inference and expert correction is rarely analyzed as a structured signal. We introduce a diagnostic alignment framework in…

Artificial Intelligence · Computer Science 2026-02-27 Dimitrios P. Panagoulias , Evangelia-Aikaterini Tsichrintzi , Georgios Savvidis , Evridiki Tsoureli-Nikita

In response to the global challenge of mental health problems, we proposes a Logical Neural Network (LNN) based Neuro-Symbolic AI method for the diagnosis of mental disorders. Due to the lack of effective therapy coverage for mental…

Computation and Language · Computer Science 2023-06-07 Yeldar Toleubay , Don Joven Agravante , Daiki Kimura , Baihan Lin , Djallel Bouneffouf , Michiaki Tatsubori

Artificial intelligence holds great promise for expanding access to expert medical knowledge and reasoning. However, most evaluations of language models rely on static vignettes and multiple-choice questions that fail to reflect the…

Large language models are increasingly integrated into decision-making in areas such as healthcare, law, finance, engineering, and government. Yet they share a critical limitation: they produce fluent outputs even when their internal…

Artificial Intelligence · Computer Science 2026-04-17 Rikard Rosenbacke , Carl Rosenbacke , Victor Rosenbacke , Martin McKee

Artificial intelligence (AI)-based decision support systems can be highly accurate yet still fail to support users or improve decisions. Existing theories of AI-assisted decision-making focus on calibrating reliance on AI advice, leaving it…

Human-Computer Interaction · Computer Science 2026-02-03 Venkatesh Sivaraman , Eric P. Mason , Mengfan Ellen Li , Jessica Tong , Andrew J. King , Jeremy M. Kahn , Adam Perer

Rare diseases affect over 300 million individuals worldwide, yet timely and accurate diagnosis remains an urgent challenge. Patients often endure a prolonged diagnostic odyssey exceeding five years, marked by repeated referrals,…

Computation and Language · Computer Science 2026-02-17 Weike Zhao , Chaoyi Wu , Yanjie Fan , Xiaoman Zhang , Pengcheng Qiu , Yuze Sun , Xiao Zhou , Yanfeng Wang , Xin Sun , Ya Zhang , Yongguo Yu , Kun Sun , Weidi Xie

Multimodal large models have shown great potential in automating pathology image analysis. However, current multimodal models for gastrointestinal pathology are constrained by both data quality and reasoning transparency: pervasive noise…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Minxi Ouyang , Lianghui Zhu , Yaqing Bao , Qiang Huang , Jingli Ouyang , Tian Guan , Xitong Ling , Jiawen Li , Song Duan , Wenbin Dai , Li Zheng , Xuemei Zhang , Yonghong He

Accurate disease prediction is vital for timely intervention, effective treatment, and reducing medical complications. While symbolic AI has been applied in healthcare, its adoption remains limited due to the effort required for…

Artificial Intelligence · Computer Science 2026-01-01 Ioanna Gemou , Evangelos Lamprou