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While LLM-based agents have shown promise for deep research, most existing approaches rely on fixed workflows that struggle to adapt to real-world, open-ended queries. Recent work therefore explores self-evolution by allowing agents to…

Artificial Intelligence · Computer Science 2026-02-05 Shuo Zhang , Chaofa Yuan , Ryan Guo , Xiaomin Yu , Rui Xu , Zhangquan Chen , Zinuo Li , Zhi Yang , Shuhao Guan , Zhenheng Tang , Sen Hu , Liwen Zhang , Ronghao Chen , Huacan Wang

LLMs have made significant progress in complex but easy-to-verify problems, yet they still struggle with discovering the unknown. In this paper, we present \textbf{AlphaResearch}, an autonomous research agent designed to discover new…

Computation and Language · Computer Science 2026-04-02 Zhaojian Yu , Kaiyue Feng , Yilun Zhao , Shilin He , Xiao-Ping Zhang , Arman Cohan

The Discovery Engine is a general purpose automated system for scientific discovery, which combines machine learning with state-of-the-art ML interpretability to enable rapid and robust scientific insight across diverse datasets. In this…

The emergence of large language models offers new possibilities for structured exploration of scientific knowledge. Rather than viewing scientific discovery as isolated ideas or content, we propose a structured approach that emphasizes the…

Artificial Intelligence · Computer Science 2025-04-15 Junlan Chen , Kexin Zhang , Daifeng Li , Yangyang Feng , Yuxuan Zhang , Bowen Deng

The cognitive sciences aim to understand intelligence by formalizing underlying operations as computational models. Traditionally, this follows a cycle of discovery where researchers develop paradigms, collect data, and test predefined…

Artificial Intelligence · Computer Science 2026-03-24 Akshay K. Jagadish , Milena Rmus , Kristin Witte , Marvin Mathony , Marcel Binz , Eric Schulz

Recent advances in self-evolution video understanding frameworks have demonstrated the potential of autonomous learning without human annotations. However, existing methods often suffer from weakly controlled optimization and uncontrolled…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Guiyi Zeng , Junqing Yu , Yi-Ping Phoebe Chen , Xu Chen , Wei Yang , Zikai Song

Traditional scientific discovery relies on an iterative hypothesise-experiment-refine cycle that has driven progress for centuries, but its intuitive, ad-hoc implementation often wastes resources, yields inefficient designs, and misses…

We present ScienceClaw + Infinite, a framework for autonomous scientific investigation in which independent agents conduct research without central coordination, and any contributor can deploy new agents into a shared ecosystem. The system…

Artificial Intelligence · Computer Science 2026-03-17 Fiona Y. Wang , Lee Marom , Subhadeep Pal , Rachel K. Luu , Wei Lu , Jaime A. Berkovich , Markus J. Buehler

Autonomous editorial systems represent an emerging class of computational frameworks that transform how large volumes of information are ingested, organized, and analyzed. This work presents a structured, continuously operating editorial…

Digital Libraries · Computer Science 2026-03-17 Ahmed Banafea

Scientific idea generation is a cornerstone of autonomous knowledge discovery, yet the iterative evolution required to transform initial concepts into high-quality research proposals remains a formidable challenge for Large Language Models…

Artificial Intelligence · Computer Science 2026-03-24 Andreas Sauter , Yuyue Zhao , Jacopo Urbani , Wenxiang Hu , Zaiqiao Meng , Lun Zhou , Xiaohui Yan , Yougang Lyu

Recent advances in generative models, particularly diffusion and auto-regressive models, have revolutionized fields like computer vision and natural language processing. However, their application to structure-based drug design (SBDD)…

Machine Learning · Computer Science 2025-07-29 Yi He , Ailun Wang , Zhi Wang , Yu Liu , Xingyuan Xu , Wen Yan

Given the remarkable performance of Large Language Models (LLMs), an important question arises: Can LLMs conduct human-like scientific research and discover new knowledge, and act as an AI scientist? Scientific discovery is an iterative…

Machine Learning · Computer Science 2025-02-24 Tingting Chen , Srinivas Anumasa , Beibei Lin , Vedant Shah , Anirudh Goyal , Dianbo Liu

Artificial intelligence has demonstrated remarkable capability in predicting scientific properties, yet scientific discovery remains an inherently physical, long-horizon pursuit governed by experimental cycles. Most current computational…

Artificial Intelligence · Computer Science 2026-03-23 Xiang Zhuang , Chenyi Zhou , Kehua Feng , Zhihui Zhu , Yunfan Gao , Yijie Zhong , Yichi Zhang , Junjie Huang , Keyan Ding , Lei Bai , Haofen Wang , Qiang Zhang , Huajun Chen

With the accumulation of data at an unprecedented rate, its potential to fuel scientific discovery is growing exponentially. This position paper urges the Machine Learning (ML) community to exploit the capabilities of large generative…

Computation and Language · Computer Science 2024-02-22 Bodhisattwa Prasad Majumder , Harshit Surana , Dhruv Agarwal , Sanchaita Hazra , Ashish Sabharwal , Peter Clark

Recent advances in data-driven evolutionary algorithms (EAs) have demonstrated the potential of leveraging historical data to improve optimization accuracy and adaptability. Despite these advancements, existing methods remain reliant on…

Neural and Evolutionary Computing · Computer Science 2026-02-16 Tao Jiang , Kebin Sun , Zhenyu Liang , Ran Cheng , Yaochu Jin , Kay Chen Tan

If autoresearch is itself a form of research, then autoresearch can be applied to research itself. We take this idea literally: we use an autoresearch loop to optimize the autoresearch loop. Every existing autoresearch system -- from…

Artificial Intelligence · Computer Science 2026-03-25 Yaonan Qu , Meng Lu

Large language models (LLMs), have shown strong potential in scientific discovery, yet existing methods still face substantial challenges in the design of research workflows and multi-role collaboration mechanisms. To mitigate these issues,…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyu Xiong , Yuqi Ren , Deyi Xiong

How can we use AI to discover a new state of the art for a scientific problem? Prior work in test-time scaling, such as AlphaEvolve, performs search by prompting a frozen LLM. We perform reinforcement learning at test time, so the LLM can…

Scholarly writing presents a complex space that generally follows a methodical procedure to plan and produce both rationally sound and creative compositions. Recent works involving large language models (LLM) demonstrate considerable…

Computation and Language · Computer Science 2023-04-04 Ryan Koo , Anna Martin , Linghe Wang , Dongyeop Kang

Autonomous research agents produce competitive solutions and professional-looking manuscripts, yet their outputs contain verifiability failures undetectable by surface-level evaluation: fabricated citations, unreproducible scores, and…