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Regularity properties of solutions for a class of quasi-stationary models in one spatial dimension for stress-modulated growth in the presence of a nutrient field are proven. At a given point in time the configuration of a body after pure…

Analysis of PDEs · Mathematics 2025-07-31 Julian Blawid , Georg Dolzmann

We present a new approach to discretizing shape optimization problems that generalizes standard moving mesh methods to higher-order mesh deformations and that is naturally compatible with higher-order finite element discretizations of…

Numerical Analysis · Mathematics 2017-06-13 A. Paganini , F. Wechsung , P. E. Farrell

We present a novel framework for PDE-constrained $r$-adaptivity of high-order meshes. The proposed method formulates mesh movement as an optimization problem, with an objective function defined as a convex combination of a mesh quality…

Numerical Analysis · Mathematics 2025-07-03 Tzanio Kolev , Boyan Lazarov , Ketan Mittal , Mathias Schmidt , Vladimir Tomov

Shape optimization models with one or more shapes are considered in this chapter. Of particular interest for applications are problems in which where a so-called shape functional is constrained by a partial differential equation (PDE)…

Optimization and Control · Mathematics 2021-07-19 Caroline Geiersbach , Estefania Loayza-Romero , Kathrin Welker

We consider an inverse problem involving the reconstruction of the solution to a nonlinear partial differential equation (PDE) with unknown boundary conditions. Instead of direct boundary data, we are provided with a large dataset of…

Numerical Analysis · Mathematics 2025-07-30 Erik Burman , Mats G. Larson , Karl Larsson , Carl Lundholm

We consider the problem of optimization of cost functionals on the infinite-dimensional manifold of diffeomorphisms. We present a new class of optimization methods, valid for any optimization problem setup on the space of diffeomorphisms by…

Optimization and Control · Mathematics 2018-05-25 Ganesh Sundaramoorthi , Anthony Yezzi

Using linearized elasticity as a convenient mechanical framework, we show that volumetric growth can be formulated as an optimization-driven process in which the growth tensor is determined implicitly by constrained optimization rather than…

Mathematical Physics · Physics 2026-05-14 Rohan Abeyaratne , Roberto Paroni , Marco Picchi Scardaoni

We introduce a method for the fast numerical approximation of linear, second-order parabolic partial differential equations (PDEs for short) with time-independent coefficients based on model order reduction techniques and the Laplace…

Numerical Analysis · Mathematics 2026-01-06 Fernando Henríquez , Jan S. Hesthaven

We propose a mathematical model that combines elastic, viscous and porous effects with growth or shrinkage due to microstructural changes. This phenomenon is important in tissue or tumor growth, as well as in dermal contraction. Although…

Numerical Analysis · Mathematics 2025-12-12 Sabia Asghar , Duncan den Bakker , Etelvina Javierre , Qiyao Peng , Fred J. Vermolen

This paper is concerned with the analysis of a new stable space-time finite element method (FEM) for the numerical solution of parabolic evolution problems in moving spatial computational domains. The discrete bilinear form is elliptic on…

Numerical Analysis · Mathematics 2018-05-14 Stephen Edward Moore

We present a framework for solving a broad class of ill-posed inverse problems governed by partial differential equations (PDEs), where the target coefficients of the forward operator are recovered through an iterative regularization scheme…

Morphoelasticity represents a foundational theory for tracing back growth, remodelling, and morphogenesis, yet crucial challenges persist. A unified growth law -- independent of a priori assumptions about constitutive relations or specified…

Soft Condensed Matter · Physics 2025-07-29 Angelo Rosario Carotenuto , Stefania Palumbo , Arsenio Cutolo , Massimiliano Fraldi

A model for morphoelastic growth, that is, growth influenced by elastic stress, driven by the absorption of nutrients is considered. The model features a multiplicative decomposition of the deformation gradient into an elastic contribution…

Analysis of PDEs · Mathematics 2026-05-05 Helmut Abels , Julian Blawid , Georg Dolzmann

Modeling the spontaneous evolution of morphology in natural systems and its preservation by proportionate growth remains a major scientific challenge. Yet, it is conceivable that if the basic mechanisms of growth and the coupled kinetic…

Soft Condensed Matter · Physics 2020-12-30 Virginia von Streng , Rami Abi-Akl , Bianca Giovanardi , Tal Cohen

We develop a novel computational framework to approximate solution operators of evolution partial differential equations (PDEs). By employing a general nonlinear reduced-order model, such as a deep neural network, to approximate the…

Numerical Analysis · Mathematics 2023-11-13 Nathan Gaby , Xiaojing Ye , Haomin Zhou

We consider shape optimization problems subject to elliptic partial differential equations. In the context of the finite element method, the geometry to be optimized is represented by the computational mesh, and the optimization proceeds by…

Optimization and Control · Mathematics 2019-07-12 Tommy Etling , Roland Herzog , Estefanía Loayza , Gerd Wachsmuth

A central question in developmental biology is how size and position are determined. The genetic code carries instructions on how to control these properties in order to regulate the pattern and morphology of structures in the developing…

Cell Behavior · Quantitative Biology 2016-12-05 Krishna Garikipati

The inverse conductivity problem aims at determining the unknown conductivity inside a bounded domain from boundary measurements. In practical applications, algorithms based on minimizing a regularized residual functional subject to PDE…

Numerical Analysis · Mathematics 2025-10-02 Lefu Cai , Zhixin Liu , Minghui Song , Xianchao Wang

This paper studies a longitudinal shape transformation model in which shapes are deformed in response to an internal growth potential that evolves according to an advection reaction diffusion process. This model extends prior works that…

Analysis of PDEs · Mathematics 2021-01-19 Dai-Ni Hsieh , Sylvain Arguillère , Nicolas Charon , Laurent Younes

We consider discretized two-dimensional PDE-constrained shape optimization problems, in which shapes are represented by triangular meshes. Given the connectivity, the space of admissible vertex positions was recently identified to be a…

Optimization and Control · Mathematics 2023-08-17 Roland Herzog , Estefanía Loayza-Romero
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