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Background: The surge in single-cell omics data exposes limitations in traditional, manually defined analysis workflows. AI agents offer a paradigm shift, enabling adaptive planning, executable code generation, traceable decisions, and…

Genomics · Quantitative Biology 2026-03-17 Yang Liu , Lu Zhou , Xiawei Du , Ruikun He , Xuguang Zhang , Rongbo Shen , Yixue Li

The increasing importance of robots and automation creates a demand for learnable controllers which can be obtained through various approaches such as Evolutionary Algorithms (EAs) or Reinforcement Learning (RL). Unfortunately, these two…

Artificial Intelligence · Computer Science 2020-09-22 Szymon Brych , Antoine Cully

Building generalist agents that can handle diverse tasks and evolve themselves across different environments is a long-term goal in the AI community. Large language models (LLMs) are considered a promising foundation to build such agents…

Large-scale reinforcement learning with verifiable rewards (RLVR) has demonstrated its effectiveness in harnessing the potential of large language models (LLMs) for single-turn reasoning tasks. In realistic reasoning scenarios, LLMs can…

The remarkable performance of Large Language Models (LLMs) highly relies on crafted prompts. However, manual prompt engineering is a laborious process, creating a core bottleneck for practical application of LLMs. This phenomenon has led to…

Computation and Language · Computer Science 2025-11-21 Qing Zhang , Bing Xu , Xudong Zhang , Yifan Shi , Yang Li , Chen Zhang , Yik Chung Wu , Ngai Wong , Yijie Chen , Hong Dai , Xiansen Chen , Mian Zhang

Large Language Model (LLM) Agents, often trained with Reinforcement Learning (RL), are constrained by a dependency on human-curated data, limiting scalability and tethering AI to human knowledge. Existing self-evolution frameworks offer an…

Machine Learning · Computer Science 2025-11-21 Peng Xia , Kaide Zeng , Jiaqi Liu , Can Qin , Fang Wu , Yiyang Zhou , Caiming Xiong , Huaxiu Yao

Large Language Models (LLMs) can be fine-tuned on domain-specific data to enhance their performance in specialized fields. However, such data often contains numerous low-quality samples, necessitating effective data processing (DP). In…

Machine Learning · Computer Science 2026-05-08 Wei Huang , Anda Cheng , Yinggui Wang , Lei Wang , Tao Wei

Engineering design optimization requires an efficient combination of a 3D shape representation, an optimization algorithm, and a design performance evaluation method, which is often computationally expensive. We present a prompt evolution…

Artificial Intelligence · Computer Science 2024-08-13 Melvin Wong , Thiago Rios , Stefan Menzel , Yew Soon Ong

The field of artificial intelligence has undergone a revolution from foundational Transformer architectures to reasoning-capable systems approaching human-level performance. We present LLMOrbit, a comprehensive circular taxonomy navigating…

Machine Learning · Computer Science 2026-04-17 Badri N. Patro , Vijay S. Agneeswaran

Automating the adaptation of software engineering (SE) research artifacts across datasets is essential for scalability and reproducibility, yet it remains largely unstudied. Recent advances in large language model (LLM)-based multi-agent…

Software Engineering · Computer Science 2025-11-27 Jingyi Chen , Xiaoyan Guo , Songqiang Chen , Shing-Chi Cheung , Jiasi Shen

Automatic Heuristic Design (AHD) has gained traction as a promising solution for solving combinatorial optimization problems (COPs). Large Language Models (LLMs) have emerged and become a promising approach to achieving AHD, but current…

Artificial Intelligence · Computer Science 2025-12-05 Jiawei Xu , Feng-Feng Wei , Wei-Neng Chen

Large language models (LLMs) are catalyzing the development of autonomous AI research agents for scientific and engineering discovery. We present FM Agent, a novel and general-purpose multi-agent framework that leverages a synergistic…

The performance of large language models (LLMs) depends on how they are prompted, with choices spanning both the high-level prompting pattern (e.g., Zero-Shot, CoT, ReAct, ReWOO) and the specific prompt content (instructions and few-shot…

Machine Learning · Computer Science 2025-11-05 Claudio Spiess , Mandana Vaziri , Louis Mandel , Martin Hirzel

Recent breakthroughs in large language models (LLMs) on reasoning tasks rely heavily on massive, high-quality datasets-typically human-annotated and thus difficult to scale. While data synthesis or distillation offers a promising…

Computation and Language · Computer Science 2025-09-30 Shaobo Wang , Zhengbo Jiao , Zifan Zhang , Yilang Peng , Xu Ze , Boyu Yang , Wei Wang , Hu Wei , Linfeng Zhang

Large language models (LLMs) have recently advanced in reasoning when optimized with reinforcement learning (RL) under verifiable rewards. Existing methods primarily rely on outcome-based supervision to strengthen internal LLM reasoning,…

Artificial Intelligence · Computer Science 2026-05-29 Siyao Song , Cong Ma , Zhihao Cheng , Shiye Lei , Minghao Li , Ying Zeng , Huaixiao Tou , Kai Jia

Scientific algorithm discovery is iterative: hypotheses are proposed, implemented, stress-tested, and revised. Current LLM-guided search systems accelerate proposal generation, but often under-represent scientific structure by optimizing…

Machine Learning · Computer Science 2026-04-02 Youssef Mroueh , Carlos Fonseca , Brian Belgodere , David Cox

Large Language Model (LLM) based agents are powerful yet fundamentally static after deployment, lacking the ability to autonomously expand capabilities, generate new tools, or evolve their reasoning. This work introduces a hierarchical…

Computation and Language · Computer Science 2026-01-21 Indrajit Kar , Sammy Zonunpuia , Zonunfeli Ralte

Historically, scientific discovery has been a lengthy and costly process, demanding substantial time and resources from initial conception to final results. To accelerate scientific discovery, reduce research costs, and improve research…

Human-Computer Interaction · Computer Science 2025-06-18 Samuel Schmidgall , Yusheng Su , Ze Wang , Ximeng Sun , Jialian Wu , Xiaodong Yu , Jiang Liu , Michael Moor , Zicheng Liu , Emad Barsoum

Large Language Model (LLM)-guided evolutionary search is increasingly used for automated algorithm discovery, yet most current methods track search progress primarily through executable programs and scalar fitness. Even when…

Computation and Language · Computer Science 2026-05-11 Sichun Luo , Yi Huang , Haochen Luo , Fengyuan Liu , Guanzhi Deng , Lei Li , Qinghua Yao , Zefa Hu , Junlan Feng , Qi Liu

Large language models (LLMs) have demonstrated remarkable capabilities across a range of text-generation tasks. However, LLMs still struggle with problems requiring multi-step decision-making and environmental feedback, such as online…

Artificial Intelligence · Computer Science 2025-02-18 Zhenfang Chen , Delin Chen , Rui Sun , Wenjun Liu , Chuang Gan