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Reasoning benchmarks measure clinical performance on clean inputs. We evaluate the step before reasoning: retrieval over real EHR notes, where negation, temporality, and family-versus-patient attribution can flip a correct answer to a wrong…

Computation and Language · Computer Science 2026-05-13 Alex Stinard

Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal…

Cancer staging is critical for patient prognosis and treatment planning, yet extracting pathologic TNM staging from unstructured pathology reports poses a persistent challenge. Existing natural language processing (NLP) and machine learning…

Artificial Intelligence · Computer Science 2025-11-04 Yeawon Lee , Christopher C. Yang , Chia-Hsuan Chang , Grace Lu-Yao

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Large language models (LLMs) show promise in automating clinical diagnosis, yet their non-transparent decision-making and limited alignment with diagnostic standards hinder trust and clinical adoption. We address this challenge by proposing…

Artificial Intelligence · Computer Science 2025-11-25 Yining Yuan , J. Ben Tamo , Micky C. Nnamdi , Yifei Wang , May D. Wang

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings…

Computation and Language · Computer Science 2026-05-28 Zhuohan Ge , Haoyang Li , Yubo Wang , Nicole Hu , Chen Jason Zhang , Qing Li

The clinical trial is a pivotal and costly process, often spanning multiple years and requiring substantial financial resources. Therefore, the development of clinical trial outcome prediction models aims to exclude drugs likely to fail and…

Machine Learning · Computer Science 2025-01-29 Wenhao Zheng , Liaoyaqi Wang , Dongshen Peng , Hongxia Xu , Yun Li , Hongtu Zhu , Tianfan Fu , Huaxiu Yao

We present SynCABEL (Synthetic Contextualized Augmentation for Biomedical Entity Linking), a framework that addresses a central bottleneck in supervised biomedical entity linking (BEL): the scarcity of expert-annotated training data.…

Computation and Language · Computer Science 2026-05-19 Adam Remaki , Christel Gérardin , Eulàlia Farré-Maduell , Martin Krallinger , Xavier Tannier

Screening patients for enrollment is a well-known, labor-intensive bottleneck that leads to under-enrollment and, ultimately, trial failures. Recent breakthroughs in large language models (LLMs) offer a promising opportunity to use…

Computation and Language · Computer Science 2026-04-30 Ziyi Chen , Mengxian Lyu , Cheng Peng , Yonghui Wu

The integration of Artificial Intelligence (AI), especially Large Language Models (LLMs), into the clinical diagnosis process offers significant potential to improve the efficiency and accessibility of medical care. While LLMs have shown…

Computation and Language · Computer Science 2024-10-15 Mingyu Derek Ma , Chenchen Ye , Yu Yan , Xiaoxuan Wang , Peipei Ping , Timothy S Chang , Wei Wang

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Large Language Model (LLM)-based autonomous agents are expected to play a vital role in the evolution of 6G networks, by empowering real-time decision-making related to management and service provisioning to end-users. This shift…

Artificial Intelligence · Computer Science 2025-09-04 Ilias Chatzistefanidis , Navid Nikaein

The production of large-scale political datasets typically demands extracting structured facts from vast piles of unstructured documents or web sources, a task that traditionally relies on expensive human experts and remains prohibitively…

Computation and Language · Computer Science 2026-03-20 Yifei Zhu , Songpo Yang , Jiangnan Zhu , Junyan Jiang

Emergency departments worldwide face rising patient volumes, workforce shortages, and variability in triage decisions that threaten the delivery of timely and accurate care. Current triage methods rely primarily on vital signs, routine…

Quantitative Methods · Quantitative Biology 2025-10-21 Kerem Delikoyun , Qianyu Chen , Win Sen Kuan , John Tshon Yit Soong , Matthew Edward Cove , Oliver Hayden

Evaluating large language models (LLMs) in diverse and challenging scenarios is essential to align them with human preferences. To mitigate the prohibitive costs associated with human evaluations, utilizing a powerful LLM as a judge has…

Computation and Language · Computer Science 2025-03-10 Tianjun Wei , Wei Wen , Ruizhi Qiao , Xing Sun , Jianghong Ma

As LLM-powered agents have been used for high-stakes decision-making, such as clinical diagnosis, it becomes critical to develop reliable verification of their decisions to facilitate trustworthy deployment. Yet, existing verifiers usually…

Artificial Intelligence · Computer Science 2026-03-04 Yichi Zhang , Nabeel Seedat , Yinpeng Dong , Peng Cui , Jun Zhu , Mihaela van de Schaar

Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical…

Artificial Intelligence · Computer Science 2026-04-10 He Geng , Yangmin Huang , Lixian Lai , Qianyun Du , Hui Chu , Zhiyang He , Jiaxue Hu , Xiaodong Tao

In this work, we present a modular and interpretable framework that uses Large Language Models (LLMs) to automate candidate assessment in recruitment. The system integrates diverse sources, including job descriptions, CVs, interview…

Information Retrieval · Computer Science 2026-03-31 Kamer Ali Yuksel , Abdul Basit Anees , Ashraf Elneima , Sanjika Hewavitharana , Mohamed Al-Badrashiny , Hassan Sawaf

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

LLMs have emerged as powerful evaluators in the LLM-as-a-Judge paradigm, offering significant efficiency and flexibility compared to human judgments. However, previous methods primarily rely on single-point evaluations, overlooking the…

Artificial Intelligence · Computer Science 2025-05-20 Luyu Chen , Zeyu Zhang , Haoran Tan , Quanyu Dai , Hao Yang , Zhenhua Dong , Xu Chen