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One of the primary goals of statistical precision medicine is to learn optimal individualized treatment rules (ITRs). The classification-based, or machine learning-based, approach to estimating optimal ITRs was first introduced in…

Methodology · Statistics 2024-06-18 Sophia Yazzourh , Nikki L. B. Freeman

As AI systems become increasingly autonomous, reliably aligning their decision-making with human preferences is essential. Inverse reinforcement learning (IRL) offers a promising approach to infer preferences from demonstrations. These…

Machine Learning · Computer Science 2025-09-22 Ondrej Bajgar , Dewi S. W. Gould , Jonathon Liu , Alessandro Abate , Konstantinos Gatsis , Michael A. Osborne

Personalized medicine has received increasing attention among statisticians, computer scientists, and clinical practitioners. A major component of personalized medicine is the estimation of individualized treatment rules (ITRs). Recently,…

Methodology · Statistics 2015-08-14 Xin Zhou , Nicole Mayer-Hamblett , Umer Khan , Michael R. Kosorok

Personalized medicine aims to tailor treatments to individual patients, especially when people respond heterogeneously to therapies. A key objective is to learn individualized treatment rules that recommend optimal treatments from patient…

Methodology · Statistics 2026-03-12 Zhu Wang

Modern action-conditioned video world models achieve strong short-horizon visual realism, yet remain unreliable on rare, interaction-critical transitions that dominate downstream planning and policy performance. Because passive…

This paper presents an empirical study regarding training probabilistic neural networks using training objectives derived from PAC-Bayes bounds. In the context of probabilistic neural networks, the output of training is a probability…

Machine Learning · Computer Science 2021-09-23 María Pérez-Ortiz , Omar Rivasplata , John Shawe-Taylor , Csaba Szepesvári

Off-policy learning (OPL) often involves minimizing a risk estimator based on importance weighting to correct bias from the logging policy used to collect data. However, this method can produce an estimator with a high variance. A common…

Machine Learning · Computer Science 2024-06-06 Imad Aouali , Victor-Emmanuel Brunel , David Rohde , Anna Korba

One of the main challenges in imitation learning is determining what action an agent should take when outside the state distribution of the demonstrations. Inverse reinforcement learning (IRL) can enable generalization to new states by…

Machine Learning · Computer Science 2024-03-04 Daniel S. Brown , Scott Niekum , Marek Petrik

Ordered Weighted $L_{1}$ (OWL) regularized regression is a new regression analysis for high-dimensional sparse learning. Proximal gradient methods are used as standard approaches to solve OWL regression. However, it is still a burning issue…

Machine Learning · Computer Science 2021-10-20 Runxue Bao , Bin Gu , Heng Huang

Precision medicine is of considerable interest in clinical, academic and regulatory parties. The key to precision medicine is the optimal treatment regime. Recently, Zhou et al. (2017) developed residual weighted learning (RWL) to construct…

Methodology · Statistics 2017-11-30 Xin Zhou , Michael R. Kosorok

The problem of inverse reinforcement learning (IRL) is relevant to a variety of tasks including value alignment and robot learning from demonstration. Despite significant algorithmic contributions in recent years, IRL remains an ill-posed…

Machine Learning · Computer Science 2020-11-18 Sreejith Balakrishnan , Quoc Phong Nguyen , Bryan Kian Hsiang Low , Harold Soh

Inverse reinforcement learning (IRL) denotes a powerful family of algorithms for recovering a reward function justifying the behavior demonstrated by an expert agent. A well-known limitation of IRL is the ambiguity in the choice of the…

Machine Learning · Computer Science 2023-04-26 Alberto Maria Metelli , Filippo Lazzati , Marcello Restelli

When estimating causal effects from observational data with numerous covariates, employing penalized covariate selection can improve the estimation efficiency. Outcome-oriented covariate selection, which involves selecting covariates…

Methodology · Statistics 2025-01-14 Wataru Hongo , Shuji Ando , Jun Tsuchida , Takashi Sozu

Reinforcement Learning with Verifiable Rewards (RLVR) improves final-answer accuracy on reasoning tasks, but it does not reliably improve reasoning quality. Because outcome rewards only assess final answers, they also reward spurious…

Machine Learning · Computer Science 2026-05-19 Chenlu Ye , Zhou Yu , Ziji Zhang , Hao Chen , Narayanan Sadagopan , Jing Huang , Tong Zhang , Anurag Beniwal

Bayesian inverse reinforcement learning (IRL) methods are ideal for safe imitation learning, as they allow a learning agent to reason about reward uncertainty and the safety of a learned policy. However, Bayesian IRL is computationally…

Machine Learning · Computer Science 2019-12-11 Daniel S. Brown , Scott Niekum

A learning method is self-certified if it uses all available data to simultaneously learn a predictor and certify its quality with a tight statistical certificate that is valid on unseen data. Recent work has shown that neural network…

Machine Learning · Computer Science 2021-12-13 Maria Perez-Ortiz , Omar Rivasplata , Emilio Parrado-Hernandez , Benjamin Guedj , John Shawe-Taylor

We introduce Prompt Curriculum Learning (PCL), a lightweight reinforcement learning (RL) algorithm that selects intermediate-difficulty prompts using a learned value model to post-train language models. Since post-training LLMs via RL…

Machine Learning · Computer Science 2025-10-02 Zhaolin Gao , Joongwon Kim , Wen Sun , Thorsten Joachims , Sid Wang , Richard Yuanzhe Pang , Liang Tan

Estimating individualized treatment rules is a central task for personalized medicine. [zhao2012estimating] and [zhang2012robust] proposed outcome weighted learning to estimate individualized treatment rules directly through maximizing the…

Methodology · Statistics 2017-10-02 Yifan Cui , Ruoqing Zhu , Michael Kosorok

Optimizing survival outcomes, such as patient survival or customer retention, is a critical objective in data-driven decision-making. Off-Policy Evaluation~(OPE) provides a powerful framework for assessing such decision-making policies…

Methodology · Statistics 2026-03-25 Kohsuke Kubota , Mitsuhiro Takahashi , Yuta Saito

For many reinforcement learning (RL) applications, specifying a reward is difficult. This paper considers an RL setting where the agent obtains information about the reward only by querying an expert that can, for example, evaluate…

Machine Learning · Computer Science 2022-02-01 David Lindner , Matteo Turchetta , Sebastian Tschiatschek , Kamil Ciosek , Andreas Krause
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