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Quantum computers have the potential to advance material design and drug discovery by performing costly electronic structure calculations. A critical aspect of this application requires optimizing the limited resources of the quantum…

The matrix product state (MPS) ansatz offers a promising approach for finding the ground state of molecular Hamiltonians and solving quantum chemistry problems. Building on this concept, the proposed technique of quantum circuit MPS (QCMPS)…

Quantum Physics · Physics 2024-10-02 Hao-En Li , Xiang Li , Jia-Cheng Huang , Guang-Ze Zhang , Zhu-Ping Shen , Chen Zhao , Jun Li , Han-Shi Hu

The deployment of large language models (LLMs) presents significant challenges due to their enormous memory footprints, low arithmetic intensity, and stringent latency requirements, particularly during the autoregressive decoding stage.…

Hardware Architecture · Computer Science 2025-11-03 Cenlin Duan , Jianlei Yang , Rubing Yang , Yikun Wang , Yiou Wang , Lingkun Long , Yingjie Qi , Xiaolin He , Ao Zhou , Xueyan Wang , Weisheng Zhao

This PhD thesis explores the potential of quantum computing to address computational challenges in high-energy physics (HEP). As the Standard Model (SM) leaves key questions unanswered and no signs of new physics have emerged since the…

Quantum Physics · Physics 2025-12-02 Jorge J. Martínez de Lejarza

Electronic structure calculations of molecular systems are among the most promising applications for fault-tolerant quantum computing (FTQC) in quantum chemistry and drug design. However, while recent algorithmic advancements such as…

Quantum circuit simulations are essential for the verification of quantum algorithms on behalf of real quantum devices. However, the memory requirements for such simulations grow exponentially with the number of qubits involved in quantum…

Quantum Physics · Physics 2025-03-04 Dongin Lee , Enhyeok Jang , Seungwoo Choi , Junwoong An , Cheolhwan Kim , Won Woo Ro

Recent advances in quantum computing have enabled the development of quantum processors with hundreds of qubits. However, noise continues to limit the amount of useful information that can be extracted from these systems, making it…

Quantum Physics · Physics 2026-04-30 J. A. Montanez-Barrera , Kristel Michielsen

A range of computational biology software (GROMACS, AMBER, NAMD, LAMMPS, OpenMM, Psi4 and RELION) was benchmarked on a representative selection of HPC hardware, including AMD EPYC 7742 CPU nodes, NVIDIA V100 and AMD MI250X GPU nodes, and an…

Quantum simulation is a foundational application for quantum computers, projected to offer insights into complex quantum systems beyond the reach of classical computation. However, with the exception of Trotter-based methods, which suffer…

Quantum Physics · Physics 2026-02-10 Amir Kalev , Itay Hen

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

Until high-fidelity quantum computers with a large number of qubits become widely available, classical simulation remains a vital tool for algorithm design, tuning, and validation. We present a simulator for the Quantum Approximate…

Quantum Physics · Physics 2023-11-14 Danylo Lykov , Ruslan Shaydulin , Yue Sun , Yuri Alexeev , Marco Pistoia

Quantum computing brings a promise of new approaches into computational quantum chemistry. While universal, fault-tolerant quantum computers are still not available, we want to utilize today's noisy quantum processors. One of their flagship…

Computational chemistry is the leading application to demonstrate the advantage of quantum computing in the near term. However, large-scale simulation of chemical systems on quantum computers is currently hindered due to a mismatch between…

Quantum Physics · Physics 2021-05-18 Gushu Li , Yunong Shi , Ali Javadi-Abhari

Peaked quantum circuits, whose output distribution is sharply concentrated on a single bitstring, have emerged as a promising candidate for verifiable quantum advantage, as the correctness of the quantum output can be checked by simply…

Quantum Physics · Physics 2026-04-24 David Kremer , Nicolas Dupuis

If classical algorithms have been successful in reproducing the estimation of expectation values of observables of some quantum circuits using off-the-shelf computing resources, matching the performance of the most advanced quantum devices…

We present and open source a quantum circuit simulator tailored to chemistry applications. More specifically, our simulator can compute the Born-rule probabilities of samples obtained from circuits containing passive fermionic linear…

Quantum simulation of chemistry and materials is predicted to be an important application for both near-term and fault-tolerant quantum devices. However, at present, developing and studying algorithms for these problems can be difficult due…

Several manufacturers have already started to commercialize near-bank Processing-In-Memory (PIM) architectures. Near-bank PIM architectures place simple cores close to DRAM banks and can yield significant performance and energy improvements…

Hardware Architecture · Computer Science 2022-04-05 Christina Giannoula , Ivan Fernandez , Juan Gómez-Luna , Nectarios Koziris , Georgios Goumas , Onur Mutlu

The quantum algorithm of Quantum Phase Estimation (QPE) was implemented to make the maximum use of GPU emulation with cuQuantum and CUDA Toolkit by NVIDIA. The input and output were handled by HDF5 to make the process as easy as possible.…

Quantum Physics · Physics 2025-07-24 Takaki Akiba , Youhi Morii

Classical simulation of quantum computers will continue to play an essential role in the progress of quantum information science, both for numerical studies of quantum algorithms and for modeling noise and errors. Here we introduce the…

Quantum Physics · Physics 2020-06-08 Gian Giacomo Guerreschi , Justin Hogaboam , Fabio Baruffa , Nicolas P. D. Sawaya