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Deep learning based approaches are now widely used across biophysics to help automate a variety of tasks including image segmentation, feature selection, and deconvolution. However, the presence of multiple competing deep learning…

Image and Video Processing · Electrical Eng. & Systems 2025-01-31 J Shepard Bryan , Pedro Pessoa , Meyam Tavakoli , Steve Presse

Large-scale models pre-trained on large-scale datasets have profoundly advanced the development of deep learning. However, the state-of-the-art models for medical image segmentation are still small-scale, with their parameters only in the…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Ziyan Huang , Haoyu Wang , Zhongying Deng , Jin Ye , Yanzhou Su , Hui Sun , Junjun He , Yun Gu , Lixu Gu , Shaoting Zhang , Yu Qiao

The automated analysis of microscopy images is a challenge in the context of single-cell tracking and quantification. This work has as goals the study of the performance of deep learning for segmenting microscopy images and the improvement…

Quantitative Methods · Quantitative Biology 2022-10-05 André O. Françani

We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Tianqi Guo , Yin Wang , Luis Solorio , Jan P. Allebach

In the field of medical imaging, the U-Net architecture, along with its variants, has established itself as a cornerstone for image segmentation tasks, particularly due to its strong performance when trained on limited datasets. Despite its…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Steven Korevaar , Ruwan Tennakoon , Alireza Bab-Hadiashar

Scaling up model and data size have demonstrated impressive performance improvement over a wide range of tasks. Despite extensive studies on scaling behaviors for general-purpose tasks, medical images exhibit substantial differences from…

Computer Vision and Pattern Recognition · Computer Science 2025-05-15 Jiarun Liu , Hong-Yu Zhou , Weijian Huang , Hao Yang , Dongning Song , Tao Tan , Yong Liang , Shanshan Wang

In recent years Deep Learning has brought about a breakthrough in Medical Image Segmentation. U-Net is the most prominent deep network in this regard, which has been the most popular architecture in the medical imaging community. Despite…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Nabil Ibtehaz , M. Sohel Rahman

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress…

Large-scale cell microscopy screens are used in drug discovery and molecular biology research to study the effects of millions of chemical and genetic perturbations on cells. To use these images in downstream analysis, we need models that…

Over the past decade, U-Net has been the dominant architecture in medical image segmentation, leading to the development of thousands of U-shaped variants. Despite its widespread adoption, there is still no comprehensive benchmark to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Fenghe Tang , Chengqi Dong , Wenxin Ma , Zikang Xu , Heqin Zhu , Zihang Jiang , Rongsheng Wang , Yuhao Wang , Chenxu Wu , Shaohua Kevin Zhou

While deep learning models have become the predominant method for medical image segmentation, they are typically not capable of generalizing to unseen segmentation tasks involving new anatomies, image modalities, or labels. Given a new…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Victor Ion Butoi , Jose Javier Gonzalez Ortiz , Tianyu Ma , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

Medical imaging plays a crucial role in modern healthcare by providing non-invasive visualisation of internal structures and abnormalities, enabling early disease detection, accurate diagnosis, and treatment planning. This study aims to…

Image and Video Processing · Electrical Eng. & Systems 2023-09-25 Walid Ehab , Yongmin Li

Medical image segmentation plays a vital role in various clinical applications, enabling accurate delineation and analysis of anatomical structures or pathological regions. Traditional CNNs have achieved remarkable success in this field.…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Seyed M. R. Modaresi , Aomar Osmani , Mohammadreza Razzazi , Abdelghani Chibani

Reliable cell segmentation and classification from biomedical images is a crucial step for both scientific research and clinical practice. A major challenge for more robust segmentation and classification methods is the large variations in…

Cell Behavior · Quantitative Biology 2017-10-31 Mo Zhang , Xiang Li , Mengjia Xu , Quanzheng Li

Convolutional neural networks (CNNs) have been successfully applied to medical image classification, segmentation, and related tasks. Among the many CNNs architectures, U-Net and its improved versions based are widely used and achieve…

Computer Vision and Pattern Recognition · Computer Science 2020-02-27 Henry H. Yu , Xue Feng , Hao Sun , Ziwen Wang

Edge learning refers to training machine learning models deployed on edge platforms, typically using new data accumulated onboard. The computational limitations on edge devices affect not only model optimisation, but also calculation of the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Anh Vu Nguyen , Dino Sejdinovic , Tat-Jun Chin

There is large consent that successful training of deep networks requires many thousand annotated training samples. In this paper, we present a network and training strategy that relies on the strong use of data augmentation to use the…

Computer Vision and Pattern Recognition · Computer Science 2015-05-19 Olaf Ronneberger , Philipp Fischer , Thomas Brox

Segmentation is a crucial step in microscopy image analysis. Numerous approaches have been developed over the past years, ranging from classical segmentation algorithms to advanced deep learning models. While U-Net remains one of the most…

Image and Video Processing · Electrical Eng. & Systems 2024-09-26 Illia Tsiporenko , Pavel Chizhov , Dmytro Fishman

While large models have achieved significant progress in computer vision, challenges such as optimization complexity, the intricacy of transformer architectures, computational constraints, and practical application demands highlight the…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Juntao Jiang , Mengmeng Wang , Huizhong Tian , Lingbo Cheng , Yong Liu
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