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We introduce an architecture for studying the behavior of large language model (LLM) agents in the absence of externally imposed tasks. Our continuous reason and act framework, using persistent memory and self-feedback, enables sustained…

Artificial Intelligence · Computer Science 2025-09-26 Stefan Szeider

The 21st century is presenting humankind with unprecedented environmental and medical challenges. The ability to design novel proteins tailored for specific purposes could transform our ability to respond timely to these issues. Recent…

Biomolecules · Quantitative Biology 2022-08-24 Noelia Ferruz , Birte Höcker

In this paper, we explore the neural architecture search (NAS) for automatic speech recognition (ASR) systems. With reference to the previous works in the computer vision field, the transferability of the searched architecture is the main…

Audio and Speech Processing · Electrical Eng. & Systems 2021-05-11 Liqiang He , Dan Su , Dong Yu

Transformer-based large language models are rapidly advancing in the field of machine learning research, with applications spanning natural language, biology, chemistry, and computer programming. Extreme scaling and reinforcement learning…

Chemical Physics · Physics 2023-04-12 Daniil A. Boiko , Robert MacKnight , Gabe Gomes

We introduce and train distributed neural architectures (DNA) in vision and language domains. DNAs are initialized with a proto-architecture that consists of (transformer, MLP, attention, etc.) modules and routers. Any token (or patch) can…

Machine Learning · Computer Science 2025-06-30 Aditya Cowsik , Tianyu He , Andrey Gromov

Natural language understanding and generation models follow one of the two dominant architectural paradigms: language models (LMs) that process concatenated sequences in a single stack of layers, and encoder-decoder models (EncDec) that…

Computation and Language · Computer Science 2022-02-17 Biao Zhang , Behrooz Ghorbani , Ankur Bapna , Yong Cheng , Xavier Garcia , Jonathan Shen , Orhan Firat

General-purpose agents perform tasks in unfamiliar environments without domain-specific manual customization. Yet no study has systematically measured how agent architecture shapes performance across heterogeneous protocols and diverse…

Human languages have evolved to be structured through repeated language learning and use. These processes introduce biases that operate during language acquisition and shape linguistic systems toward communicative efficiency. In this paper,…

Computation and Language · Computer Science 2024-12-16 Tom Kouwenhoven , Max Peeperkorn , Tessa Verhoef

Large language models (LLMs) are increasingly used as proposal generators for evolutionary robot design, yet most loops remain memoryless: simulator results shape the next population but are not preserved as reusable design knowledge. We…

Robotics · Computer Science 2026-05-26 Yunfei Wang , Xiaohao Xu , Yang Li , Xiaonan Huang

We present a modular framework powered by large language models (LLMs) that automates and streamlines key tasks across the early-stage computational drug discovery pipeline. By combining LLM reasoning with domain-specific tools, the…

Parameter-efficient tuning (PET) methods fit pre-trained language models (PLMs) to downstream tasks by either computing a small compressed update for a subset of model parameters, or appending and fine-tuning a small number of new model…

Computation and Language · Computer Science 2023-05-29 Neal Lawton , Anoop Kumar , Govind Thattai , Aram Galstyan , Greg Ver Steeg

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Quantitative Methods · Quantitative Biology 2025-01-08 Benoit Gaujac , Jérémie Donà , Liviu Copoiu , Timothy Atkinson , Thomas Pierrot , Thomas D. Barrett

We apply a Transformer architecture, specifically BERT, to learn flexible and high quality molecular representations for drug discovery problems. We study the impact of using different combinations of self-supervised tasks for pre-training,…

Machine Learning · Computer Science 2020-11-30 Benedek Fabian , Thomas Edlich , Héléna Gaspar , Marwin Segler , Joshua Meyers , Marco Fiscato , Mohamed Ahmed

The influence of deep learning is continuously expanding across different domains, and its new applications are ubiquitous. The question of neural network design thus increases in importance, as traditional empirical approaches are reaching…

Neural and Evolutionary Computing · Computer Science 2021-01-29 Anton Muravev , Jenni Raitoharju , Moncef Gabbouj

Large Language Model (LLM)-based agents are increasingly employed to automate complex software engineering tasks, such as program repair and issue resolution. These agents operate by autonomously generating natural language thoughts,…

Software Engineering · Computer Science 2025-10-09 Islem Bouzenia , Michael Pradel

Models based on machine learning can enable accurate and fast molecular property predictions, which is of interest in drug discovery and material design. Various supervised machine learning models have demonstrated promising performance,…

Machine Learning · Computer Science 2022-12-15 Jerret Ross , Brian Belgodere , Vijil Chenthamarakshan , Inkit Padhi , Youssef Mroueh , Payel Das

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

Improvements in language model capabilities are often attributed to increasing model size or training data, but in some cases smaller models trained on curated data or with different architectural decisions can outperform larger ones…

The success of language models, especially transformer-based architectures, has trickled into other domains giving rise to "scientific language models" that operate on small molecules, proteins or polymers. In chemistry, language models…

Chemical Physics · Physics 2024-10-22 Nikita Janakarajan , Tim Erdmann , Sarath Swaminathan , Teodoro Laino , Jannis Born

Fast expansion of natural language functionality of intelligent virtual agents is critical for achieving engaging and informative interactions. However, developing accurate models for new natural language domains is a time and data…

Computation and Language · Computer Science 2018-05-07 Anuj Goyal , Angeliki Metallinou , Spyros Matsoukas